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Journal of Biological Chemistry, ISSN 0021-9258, 09/2008, Volume 283, Issue 36, pp. 24770 - 24780
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are characteristic age-related changes of post-mitotic retinal pigment... 
LIPOFUSCIN FLUOROPHORE | RAT | DYSTROPHY | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPONENT | RPE CELLS | N-RETINYLIDENE ETHANOLAMINE | BINDING | PHOTORECEPTORS | Retinoids - metabolism | Epithelial Cells - metabolism | Lipofuscin - pharmacology | Antioxidants - metabolism | Humans | Lysosomes - genetics | Rats, Long-Evans | Adenosine Triphosphate - genetics | Phagocytosis - genetics | Membrane Potential, Mitochondrial - drug effects | Mitosis - genetics | Oxidative Phosphorylation - drug effects | DNA, Mitochondrial - genetics | Lysosomes - metabolism | Aging - genetics | Cell Death - genetics | Mitochondria - genetics | Adenosine Triphosphate - metabolism | Membrane Potential, Mitochondrial - genetics | Pyruvic Acid - metabolism | Lysosomes - pathology | Cell Death - drug effects | Cell Line | Phagocytosis - drug effects | DNA, Mitochondrial - metabolism | Rats | Epithelial Cells - pathology | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - pathology | Aging - pathology | Pigment Epithelium of Eye - metabolism | Macular Degeneration - metabolism | Point Mutation | Pyridinium Compounds - pharmacology | Animals | Mitosis - drug effects | Macular Degeneration - genetics | Glucose - metabolism | Pigment Epithelium of Eye - pathology | Pyridinium Compounds - metabolism | Lipofuscin - metabolism | Retinoids - pharmacology | Aging - metabolism | Macular Degeneration - pathology | Index Medicus | Molecular Basis of Cell and Developmental Biology
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, pp. e67263 - e67263
With ageing extracellular material is deposited in Bruch's membrane, as drusen. Lipofuscin is deposited in retinal pigment epithelial cells. Both of these... 
RNA, Small Interfering - genetics | Retinal Pigment Epithelium - metabolism | Up-Regulation | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Epithelial Cells - drug effects | Humans | Cytoplasm - metabolism | Interleukin-1beta - genetics | Mice, 129 Strain | Gene Knockdown Techniques | ATP-Binding Cassette Transporters - deficiency | Retinal Pigment Epithelium - pathology | Endocytosis | ATP-Binding Cassette Transporters - genetics | Inflammation Mediators - metabolism | Geographic Atrophy - immunology | Interleukin-1beta - biosynthesis | Cell Line | Protein Precursors - genetics | Signal Transduction | Retinoids - physiology | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Geographic Atrophy - pathology | Protein Precursors - biosynthesis | Epithelial Cells - immunology | Retinal Pigment Epithelium - immunology | Mice | Multiplexing | Pathogenesis | Retina | Vitronectin | Biology | Activation | Retinal pigment epithelium | Caspase-1 | Macular degeneration | Interleukin 6 | Proteins | Receptors | Interleukin 2 | Older people | Amyloid | Degeneration | Vascular endothelial growth factor | Interleukin 8 | Enzyme-linked immunosorbent assay | Age | Immune system | Cytokines | Caspase | Inflammation | Hazards | Pattern recognition | Tumor necrosis factor-α | Epithelium | Aging (materials) | Lysine | Carboxymethyllysine | Photoreceptors | Chemokines | Monocyte chemoattractant protein 1 | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2004, Volume 101, Issue 22, pp. 8491 - 8496
Docosahexaenoic acid (DHA) is a lipid peroxidation target in oxidative injury to retinal pigment epithelium (RPE) and retina. Photoreceptor and synaptic... 
Oxidative stress | Biological Sciences | Transcriptional regulatory elements | Neurons | DNA | DNA fragmentation | Photoreceptors | Lipids | Retina | Fatty acids | Apoptosis | Neuroprotection | Bcl-2 proteins | Age-related macular degeneration | Neurodegeneration | Docosanoids | INDUCED APOPTOSIS | RHESUS-MONKEYS | MULTIDISCIPLINARY SCIENCES | neurodegeneration | LIGHT-DAMAGE | BINDING PROTEIN | docosanoids | PHOTORECEPTOR CELLS | TERM INFANTS | OUTER SEGMENT MEMBRANES | BRAIN ISCHEMIA | neuroprotection | FREE FATTY-ACIDS | GENE-EXPRESSION | age-related macular degeneration | Cell Line | Interleukin-1 - metabolism | Pigment Epithelium of Eye - drug effects | Epithelial Cells - metabolism | Oxidative Stress | Docosahexaenoic Acids - chemistry | Cyclooxygenase 2 | Epithelial Cells - drug effects | Humans | Membrane Proteins | Pigment Epithelium of Eye - metabolism | Docosahexaenoic Acids - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Isoenzymes - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | DNA Fragmentation | Caspase 3 | Molecular Structure | Apoptosis - physiology | Pigment Epithelium of Eye - cytology | Lipid Peroxidation | Docosahexaenoic Acids - metabolism | Macular degeneration | Research | Neurology | Pigments | Oxidation | Eyes & eyesight | Cells | Stress | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e69563 - e69563
Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal... 
OXIDATIVE STRESS | HUR | BINDING PROTEIN P62 | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | VISUAL IMPAIRMENT | KINASE | MACULAR DEGENERATION | BODY FORMATION | EXPRESSION | MEDIATED PROTEOLYSIS | ELAV-Like Protein 1 | Immunohistochemistry | Retinal Pigment Epithelium - metabolism | Immunoprecipitation | Sequestosome-1 Protein | Epithelial Cells - drug effects | Humans | Autophagy | Aminoimidazole Carboxamide - pharmacology | Ribonucleotides - pharmacology | Proteasome Endopeptidase Complex - drug effects | RNA Interference | Epithelial Cells - cytology | Retinal Pigment Epithelium - drug effects | Cell Line | Microscopy, Electron, Transmission | ELAV Proteins - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Leupeptins - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Adaptor Proteins, Signal Transducing - genetics | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | ELAV Proteins - genetics | Retinal Pigment Epithelium - cytology | Macular degeneration | Proteins | RNA | Proteolysis | Genes | Genetic transcription | Protein binding | Elderly people | Post-transcription | Oxidative stress | Disease | Laboratories | Lipid peroxidation | Retina | Biology | Kinases | Accumulation | Retinal pigment epithelium | Aging | Degeneration | Inhibition | Age | Visually handicapped people | HuR protein | Cleaning | Pharmacology | Gene expression | Medicine | Studies | Pathology | Hospitals | Molecular modelling | Aggregates | Proteasomes | Clinical medicine | Elderly | Phagocytosis | Geriatrics | Apoptosis | Index Medicus
Journal Article
Journal Article
Nature Protocols, ISSN 1754-2189, 04/2009, Volume 4, Issue 5, pp. 662 - 673
Journal Article
Experimental Eye Research, ISSN 0014-4835, 07/2019, Volume 184, pp. 15 - 23
To assess the effect of somatostatin (SST) on the permeability of human retinal pigment epithelial cells. We conducted two experiments, exposing cells from... 
TER | Hypoxia | SST | VEGF | Retinal pigment epithelium | OCTREOTIDE | ACTIVATION | ANALOGS | RECEPTOR | PROLIFERATIVE DIABETIC-RETINOPATHY | MACULAR EDEMA | VITREOUS FLUID | GLUTAMATE | OPHTHALMOLOGY | MICE | EXPRESSION | Permeability | Endothelial growth factors | Immunochemistry | Analysis | Cells | Fluorescein
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2012, Volume 53, Issue 6, pp. 1298 - 1307
Oxidative damage and inflammation are related to the pathogenesis of age-related macular degeneration (AMD). Epidemiologic studies suggest that insufficient... 
Lutein | Zeaxanthin | Inflammation | Photooxidation | RPE | Proteasome | C-REACTIVE PROTEIN | OXIDATIVE STRESS | AGE-RELATED MACULOPATHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | COMPLEMENT FACTOR-H | PROTEOLYTIC PATHWAY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | CONJUGATING ENZYMES | NF-KAPPA-B | UBIQUITIN-PROTEASOME PATHWAY | Radiation-Protective Agents - metabolism | Interleukin-8 - genetics | Retinal Pigment Epithelium - metabolism | Gene Expression - drug effects | Humans | Zeaxanthins | Down-Regulation - radiation effects | Macular Degeneration - drug therapy | Photochemical Processes | Retinal Pigment Epithelium - pathology | Complement Factor H - secretion | Ultraviolet Rays | Culture Media | Inflammation Mediators - metabolism | Radiation-Protective Agents - pharmacology | Chemokine CCL2 - metabolism | Oxidative Stress - radiation effects | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Retinal Pigment Epithelium - drug effects | Interleukin-6 - genetics | Oxidation-Reduction | Cells, Cultured | Chemokine CCL2 - genetics | Lutein - metabolism | Down-Regulation - drug effects | Gene Expression - radiation effects | Complement Factor H - metabolism | Xanthophylls - metabolism | Xanthophylls - pharmacology | Proteasome Endopeptidase Complex - metabolism | Complement Factor H - genetics | Dietary Supplements | Lutein - pharmacology | Macular Degeneration - pathology | Macular degeneration | Analysis | Genes | Genetic research | Universities and colleges | Ophthalmology | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 10/2018, Volume 315, Issue 4, pp. C457 - C473
The basolateral membrane anion conductance of the retinal pigment epithelium (RPE) is a key component of the transepithelial Cl- transport pathway. Although... 
Anion permeability | Anion conductance | RPE | anion permeability | PHYSIOLOGY | BESTROPHIN | ION-TRANSPORT | CL-CHANNEL | K+ CURRENTS | CLC-2 | FUNCTIONAL-PROPERTIES | CELL BIOLOGY | PORE | anion conductance | CYSTIC-FIBROSIS | ACTIVATED CHLORIDE CHANNELS | CFTR | Membranes | Membrane conductance | Cellular biology | <