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Cancer, ISSN 0008-543X, 08/2014, Volume 120, Issue 15, pp. 2316 - 2324
Journal Article
06/2012
Most human breast tumors have mutations in the growth factor/phosphatidylinositol 3’ kinase (PI3K) pathway. These can occur in genes coding for receptors,... 
breast cancer | 0307 | Pik3ca mutations
Dissertation
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 11/2017, Volume 36, Issue 1, pp. 164 - 164
Background: Parallel to complex alteration in molecular and cellular events, enrichment of cancer stem cells (CSC) contributes significantly in deliberation... 
PIK3CA regulators | CSC-enrichment | NF-κB-TNFα-PIK3CA loop | ACTIVATION | NF-kappa B-TNF alpha-PIK3CA loop | PHOSPHORYLATION | PIK3CA AMPLIFICATION | OVARIAN-CANCER | DRUG-RESISTANCE | PI3K/AKT PATHWAY | IN-VITRO | ONCOLOGY | NF-KAPPA-B | EXPRESSION | CARCINOMA | Index Medicus
Journal Article
Genetics in Medicine, ISSN 1098-3600, 09/2017, Volume 19, Issue 9, pp. 989 - 997
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Journal of Applied Biotechnology Reports, ISSN 2322-1186, 12/2018, Volume 5, Issue 1, pp. 8 - 12
Journal Article
Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 42, pp. 5648 - 5650
  The serine-threonine kinase AKT1 is a central player in the oncogenic pathway controlled by PI3K. Recently, a somatic mutation in AKT1 (E17K) has been... 
AKT1 | Mutation | PIK3CA | Cancer | Signal transduction | Oncology | Genetics | Kinases | Tumors
Journal Article
Anticancer Research, ISSN 0250-7005, 05/2018, Volume 38, Issue 5, pp. 2831 - 2839
Journal Article
European Journal of Cancer, ISSN 0959-8049, 01/2018, Volume 89, pp. 64 - 71
Understanding the biology of breast cancer is important for guiding treatment strategies and revealing resistance mechanisms. Our objectives were to... 
Systemic therapy | Breast cancer | Next-generation sequencing | Somatic mutations | PIK3CA | TP53 | PIK3CA MUTATIONS | GENE | ONCOLOGY | PATHWAY | GROWTH | Index Medicus
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 02/2017, Volume 35, Issue 5, pp. 569 - 569
Journal Article
Journal of Hand Surgery (European Volume), ISSN 1753-1934, 9/2018, Volume 43, Issue 7, pp. 756 - 760
Somatic PIK3CA mutations may relate to pathogenesis of isolated macrodactyly. We set up to test the association between PIK3CA mutations with isolated... 
PIK3CA-related overgrowth spectrum | Sanger DNA sequencing | Macrodactyly | PIK3CA mutation | SURGERY | HANDS | ORTHOPEDICS | FEET
Journal Article