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by Koboldt, Daniel C and Fulton, Robert S and McLellan, Michael D and Schmidt, Heather and Kalicki-Veizer, Joelle and McMichael, Joshua F and Fulton, Lucinda L and Dooling, David J and Ding, Li and Mardis, Elaine R and Wilson, Richard K and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Coope, Robin J. N and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Schein, Jacqueline E and Shafiei, Arash and Sipahimalani, Payal and Slobodan, Jared R and Stoll, Dominik and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and Zeng, Thomas and Zhao, Yongjun and Birol, Inanc and Jones, Steven J. M and Marra, Marco A and Cherniack, Andrew D and Saksena, Gordon and Onofrio, Robert C and Pho, Nam H and Carter, Scott L and Schumacher, Steven E and Tabak, Barbara and Hernandez, Bryan and Gentry, Jeff and Nguyen, Huy and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Getz, Gad and Gabriel, Stacey B and Meyerson, Matthew and Chin, Lynda and Kucherlapati, Raju and Hoadley, Katherine A and Auman, J. Todd and Fan, Cheng and Turman, Yidi J and Shi, Yan and Li, Ling and Topal, Michael D and He, Xiaping and Chao, Hann-Hsiang and Prat, Aleix and Silva, Grace O and Iglesia, Michael D and Zhao, Wei and Usary, Jerry and Berg, Jonathan S and Adams, Michael and Booker, Jessica and Wu, Junyuan and Gulabani, Anisha and Bodenheimer, Tom and Hoyle, Alan P and Simons, Janae V and Soloway, Matthew G and Mose, Lisle E and Jefferys, Stuart R and Balu, Saianand and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Malik, Simeen and Mahurkar, Swapna and Shen, Hui and Weisenberger, Daniel J and Triche Jr, Timothy and Lai, Phillip H and ... and The Cancer Genome Atlas Network and Canc Genome Atlas Network and Cancer Genome Atlas Network
Nature (London), ISSN 1476-4687, 2012, Volume 490, Issue 7418, pp. 61 - 70
.... Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes... 
PATHWAYS | TARGET | BASAL-LIKE | SUPPRESSOR | PIK3CA GENE | SUBTYPES | MULTIDISCIPLINARY SCIENCES | HIGH-FREQUENCY | LUMINAL-B | CANCER | MUTATIONAL EVOLUTION | GATA3 Transcription Factor - genetics | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Genomics | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Gene Expression Profiling | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | DNA Methylation | DNA Mutational Analysis | Female | Genes, BRCA1 | Genes, Neoplasm - genetics | Breast Neoplasms - classification | RNA, Messenger - genetics | Retinoblastoma Protein - metabolism | DNA Copy Number Variations - genetics | Genes, p53 - genetics | Mutation - genetics | Genetic Heterogeneity | Genome, Human - genetics | Phosphatidylinositol 3-Kinases - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Genes, erbB-2 - genetics | Proteomics | Protein Array Analysis | RNA, Neoplasm - genetics | MAP Kinase Kinase Kinase 1 - genetics | MicroRNAs - genetics | Breast tumors | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Identification and classification | Cancer | Proteins | DNA methylation | Genetics | Breast cancer | Mutation | Càncer de mama | Oncologia | Oncology | Gene expression | Expressió gènica | Genòmica
Journal Article
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2013, Volume 209, Issue 5, pp. 465.e1 - 465.e9
Journal Article
Clinical cancer research, ISSN 1557-3265, 2009, Volume 15, Issue 19, pp. 6008 - 6017
Journal Article
BMC cancer, ISSN 1471-2407, 02/2013, Volume 13, Issue 1, pp. 49 - 49
...: Only PIK3CA mutations occasionally coexisted with other gene mutations. In univariate analysis, prognostic significance for survival... 
PI3K gene mutations | Biomarkers | EGFR ligands | BRAF | KRAS | Cetuximab | Epidermal growth factor receptor | 1ST-LINE TREATMENT | LEUCOVORIN | EPIREGULIN | STATISTICS | FLUOROURACIL | CHEMOTHERAPY | BREAST-CANCER | PANITUMUMAB | MUTATION STATUS | ONCOLOGY | Colorectal Neoplasms - genetics | Humans | Middle Aged | Glycoproteins - metabolism | Male | Antineoplastic Agents - therapeutic use | Epiregulin | Amphiregulin | RNA, Messenger - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | EGF Family of Proteins | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adult | Female | Adenocarcinoma - genetics | Retrospective Studies | Colorectal Neoplasms - metabolism | Genes, ras - genetics | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Epidermal Growth Factor - metabolism | Genotype | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Phosphatidylinositol 3-Kinase - genetics | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - secondary | Aged | Drugs | Medical research | Care and treatment | Genes | Colorectal cancer | Adverse and side effects | Metastasis | Antineoplastic agents | Formaldehyde | Antimitotic agents | Messenger RNA | Epidermal growth factor | Codon | Gene mutations | Analysis | Monoclonal antibodies | Medicine, Experimental | Genetic aspects | Biological markers | Health aspects
Journal Article
Clinical colorectal cancer, ISSN 1533-0028, 2012, Volume 11, Issue 2, pp. 143 - 150
Micro-Abstract To determine biomarkers predictive of benefit to anti-EGFR (epidermal growth factor receptor) monoclonal antibodies in patients with KRAS... 
Hematology, Oncology and Palliative Medicine | Gastroenterology and Hepatology | PTEN | Anti-EGFR | Biomarker | KRAS | PIK3CA mutations | Colorectal cancer | METHYLATION | ACTIVATION | BRAF | EGFR | PANITUMUMAB | ONCOLOGY | CETUXIMAB PLUS IRINOTECAN | DEREGULATION | RESISTANCE | PROMOTER | ASSOCIATION | Immunohistochemistry | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Promoter Regions, Genetic - genetics | Antibodies, Monoclonal, Humanized | Neoplasm Metastasis | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Cetuximab | Colorectal Neoplasms - mortality | PTEN Phosphohydrolase - genetics | Receptor, Epidermal Growth Factor - immunology | Kaplan-Meier Estimate | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Class I Phosphatidylinositol 3-Kinases | Aged | Biomarkers, Tumor - genetics | Mutation | Genetic aspects | Research | Gene mutations | Biological markers | Gene expression | anti-EGFR | colorectal cancer | biomarker
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2010, Volume 120, Issue 1, pp. 121 - 127
Journal Article
Journal Article