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by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
The Journal of Pathology, ISSN 0022-3417, 03/2014, Volume 232, Issue 4, pp. 415 - 427
Colorectal cancer (CRC) is the third most common cancer in the USA. MicroRNAs play important roles in the pathogenesis of CRC. In this study, we investigated... 
miR‐30b | colorectal cancer | proliferation | BCL2 | apoptosis | PIK3CD | KRAS | miR-30b | GENE-MUTATIONS | AMPLIFICATION | METASTASIS | ONCOLOGY | RAS | PROSTATE-CANCER | C-MYC | COLON | PATHOLOGY | EXPRESSION | CARCINOMA | PROGRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Cell Proliferation | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Male | MicroRNAs - metabolism | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Transfection | Time Factors | G1 Phase Cell Cycle Checkpoints | Female | Cell Differentiation | 3' Untranslated Regions | Binding Sites | Genes, Tumor Suppressor | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Proto-Oncogene Proteins - metabolism | Signal Transduction | HCT116 Cells | Computational Biology | Kaplan-Meier Estimate | Proto-Oncogene Proteins - genetics | Tumor Burden | Phosphatidylinositol 3-Kinases - genetics | Animals | Class I Phosphatidylinositol 3-Kinases | Mice, Nude | Mice, Inbred BALB C | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Neoplasm Staging | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | MicroRNA | Analysis | Colorectal cancer | Tumors
Journal Article
by Wang, Y and Wang, WJ and Liu, LY and Hou, J and Ying, WJ and Hui, XY and Zhou, QH and Liu, DR and Yao, HL and Sun, JQ and Wang, XC
JOURNAL OF CLINICAL IMMUNOLOGY, ISSN 0271-9142, 11/2018, Volume 38, Issue 8, pp. 854 - 863
PurposeWe aimed to report the clinical manifestations and immunological features of activated phosphatidylinositol 3-kinase syndrome 1 (APDS1) in a Chinese... 
primary immunodeficiency | PIK3CD | MUTATIONS | IMMUNOLOGY | PIK3CD gene | Activated phosphoinositide 3-kinase syndrome | MTOR | rapamycin | FEATURES | Medicine, Experimental | Medical research | B cells | T cells | Health aspects | Immunodeficiency
Journal Article
Journal Article
Leukemia, ISSN 0887-6924, 11/2017, Volume 31, Issue 11, pp. 2355 - 2364
Journal Article
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 01/2019, Volume 143, Issue 1, pp. 266 - 275
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2019, Volume 10, p. 753
Journal Article
ISSN 0091-6749, 2016
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 11/2018, Volume 38, Issue 8, pp. 854 - 863
Journal Article