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Cancer Research, ISSN 0008-5472, 08/2018, Volume 78, Issue 16, pp. 4774 - 4785
The established role of hypoxia-induced signaling in prostate cancer growth, metastasis, and response to treatment suggests that a method to image hypoxia in... 
HETEROGENEITY | ADC | PREDICTS | ONCOLOGY | RADICAL PROSTATECTOMY | DIFFUSION | PIMONIDAZOLE | PERFUSION | T2
Journal Article
LANCET ONCOLOGY, ISSN 1470-2045, 10/2005, Volume 6, Issue 10, pp. 757 - 764
Background The concentration of osteopontin (SPP1) in plasma is associated with tumour hypoxia. The DAHANCA 5 trial found that the hypoxia radiosensitiser... 
METASTASIS | TUMOR HYPOXIA | SOLID TUMORS | ONCOLOGY | MARKER | OXYGENATION | GENE-EXPRESSION | CARCINOMAS | ELECTRODES | PIMONIDAZOLE
Journal Article
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 10/2003, Volume 89, Issue 7, pp. 1290 - 1297
Glucose transporter-1 protein (GLUT1) and carbonic anhydrase IX (CAIX) are regulated by hypoxia inducible factor-1 (HIF-1) and have been studied as putative... 
hypoxia | CARBONIC-ANHYDRASE-IX | TUMOR HYPOXIA | OXYGEN MEASUREMENTS | PIMONIDAZOLE BINDING | TREATMENT TIME | carbonic anhydrase IX | ONCOLOGY | GLUCOSE-TRANSPORTER | bladder cancer | TRANSITIONAL-CELL CARCINOMA | POOR SURVIVAL | glucose transporter protein 1 (GLUT1) | pimonidazole | LOCAL-CONTROL | PROGNOSTIC-SIGNIFICANCE
Journal Article
Scientific Reports, ISSN 2045-2322, 06/2015, Volume 5, Issue 1, p. 10657
Optical methods using phosphorescence quenching by oxygen are suitable for sequential monitoring and non-invasive measurements for oxygen concentration (OC)... 
METABOLISM | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | TISSUE | MOUSE | BETA-CELL LINE | PIMONIDAZOLE | GRADIENTS | Cell Hypoxia - physiology | Animals | Humans | Cell Line, Tumor | Molecular Imaging - methods | Mice | Oxygen - metabolism | Mitochondria | Oxygen | Dyes | Anoxia | Spatial discrimination | Phosphorescence | Insulin
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2006, Volume 80, Issue 2, pp. 123 - 131
Hypoxia adversely affects treatment outcome in human uterine cervical cancer. Here, we present the results of a prospective international multi-centre study... 
Uterine cervix carcinoma | Tumour oxygenation | Pimonidazole | Hypoxia marker
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2010, Volume 96, Issue 1, pp. 116 - 122
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 3
Objectives Hypoxia in solid tumors occurs when metabolic demands in tumor cells surpass the delivery of oxygenated blood. We hypothesize that the... 
SURROGATE | CERVIX | POSITRON-EMISSION-TOMOGRAPHY | ADVANCED BREAST-CANCER | THERAPY | METABOLISM | MULTIDISCIPLINARY SCIENCES | MARKERS | FDG | PIMONIDAZOLE | BLOOD-FLOW
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 80, Issue 4, pp. 1205 - 1213
Journal Article
Journal of Biomedical Optics, ISSN 1083-3668, 6/2018, Volume 23, Issue 6, pp. 067001 - 067001
Tumor hypoxia is a critical indicator of poor clinical outcome in patients with cancers of the breast, cervix, and oral cavity. The ability to noninvasively... 
diffuse reflectance | hypoxia | vascular oxygenation | CANCERS | BIOCHEMICAL RESEARCH METHODS | SQUAMOUS-CELL CARCINOMA | OXYGENATION STATUS | PIMONIDAZOLE | OPTICS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PROGRESSION
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 03/2012, Volume 23, Issue 3, pp. 324 - 329
We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging of tumor hypcoda. GPU-167 comprises a tricarbocyanine dye as an NIR... 
SOLID TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGIONS | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | PIMONIDAZOLE | BINDING | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Cell Hypoxia | Fluorescent Dyes - chemistry | Carbocyanines - chemistry | Animals | Mice, Nude | Mice | Spectroscopy, Near-Infrared - methods | Neoplasms - pathology | Nitroimidazoles - chemistry
Journal Article
British Journal of Radiology, ISSN 0007-1285, 2019, Volume 92, Issue 1093, p. 20180036
Hypoxia is a generic micro-environmental factor of solid tumours. High levels of hypoxia lead to resistance to radiotherapy, which can be targeted by adding... 
BLADDER-CANCER | CLASSIFIER | IMPACT | TUMOR HYPOXIA | CERVICAL-CANCER | PIMONIDAZOLE | ADVANCED HEAD | ASSOCIATION | RADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NECK-CANCER
Journal Article