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NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 11/2016, Volume 44, Issue 20, pp. 9860 - 9871
The major human pathogen Mycobacterium tubercu-losis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin... 
BACTERIAL PERSISTENCE | CRYSTAL-STRUCTURE | TOXIN | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | IDENTIFICATION | PRE-RIBOSOMAL-RNA | PIN-DOMAIN | RIBONUCLEASE | MOLECULAR-MECHANISMS
Journal Article
Biology Direct, ISSN 1745-6150, 03/2006, Volume 1, Issue 1, pp. 7 - 7
Background: All archaeal and many bacterial genomes contain Clustered Regularly Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the... 
PROTEIN | MESSENGER-RNA | NONCODING RNAS | ANTISENSE RNA | BIOLOGY | DNA-REPAIR SYSTEM | SECONDARY STRUCTURE | C-ELEGANS | PSI-BLAST | PIN-DOMAIN | REPEATS
Journal Article
NATURE STRUCTURAL & MOLECULAR BIOLOGY, ISSN 1545-9993, 11/2017, Volume 24, Issue 11, pp. 954 - 954
The 40S small ribosomal subunit is cotranscriptionally assembled in the nucleolus as part of a large chaperone complex called the 90S preribosome or... 
EUKARYOTIC RIBOSOME | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | EM STRUCTURE DETERMINATION | SMALL NUCLEOLAR RNA | PIN DOMAIN | CELL BIOLOGY | BIOPHYSICS | BIOGENESIS | ASSEMBLY EVENTS | U3 SNORNA | PROCESSING COMPLEXES
Journal Article
RNA, ISSN 1355-8382, 12/2018, Volume 24, Issue 12, pp. 1677 - 1692
Pre-rRNA processing generates mature 18S, 5.8S, and 28S/25S rRNAs through multistage removal of surrounding 5'-ETS/3'-ETS and intervening ITS1/ITS2 segments.... 
RRP6 | ARABIDOPSIS-THALIANA | COMPLEX | DI53 | CENTRAL CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | pre-rRNA processing | CORE EXOSOME | EXONUCLEASE | EUKARYOTIC EXOSOME | PIN DOMAIN | YEAST | XRN2 | IN-VIVO | DEGRADATION | exosome
Journal Article
FEBS Journal, ISSN 1742-464X, 12/2009, Volume 276, Issue 24, pp. 7386 - 7399
In human monocyte‐derived macrophages, the MCPIP gene (monocyte chemoattractant protein‐induced protein) is strongly activated by interleukin‐1β (IL‐1β). Using... 
IL‐1β transcript degradation | PIN domain | inflammation | MCPIP | RNase | Inflammation | IL-1β transcript degradation | CELLS | DECAY | TRISTETRAPROLIN | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | PREDICTION | AU-RICH ELEMENTS | DESTABILIZATION | IL-1 beta transcript degradation | BINDING | PIN DOMAINS
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2018, Volume 475, Issue 12, pp. 2091 - 2105
DIS3 (defective in sister chromatid joining) is the catalytic subunit of the exosome, a protein complex involved in the 3'-5' degradation of RNAs. DIS3 is a... 
MULTIPLE-MYELOMA | COMPLEX | CYTOPLASMIC MESSENGER-RNA | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION PATHWAY | CORE EXOSOME | EXORIBONUCLEASE DIS3 | MUTATIONS | RIBOSOMAL-RNA | PIN DOMAIN | Index Medicus | RNA stability | PIN domain | myeloma | DIS3 | CMML
Journal Article
JOURNAL OF BACTERIOLOGY, ISSN 0021-9193, 02/2018, Volume 200, Issue 3
Type II toxin-antitoxin (TA) systems play a critical role in the establishment and maintenance of bacterial dormancy. They are composed of a protein toxin and... 
SITE | BACTERIAL PERSISTENCE | NTHi | MAZF | RNA | tRNA | toxin-antitoxin | ESCHERICHIA-COLI | INITIATOR TRANSFER-RNA | ANTITOXIN SYSTEMS | MICROBIOLOGY | PIN-DOMAIN | PROTEIN-SYNTHESIS | endonuclease | MESSENGER-RNAS | persisters | 18S RIBOSOMAL-RNA
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 7381 - 14
MCPIP1, also known as Regnase-1, is a ribonuclease crucial for regulation of stability of transcripts related to inflammatory processes. Here, we report that... 
COMPLEX | PROTEIN | REGNASE-1 | STABILIZATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | DEGRADATION | ROQUIN | MESSENGER-RNA DECAY | RIBOSOMAL-RNA | PIN-DOMAIN | Ribonuclease A | Interleukin 6 | Transcription | Substrate specificity | Oligonucleotides | Affinity | Inflammation | Nucleotides | Zinc finger proteins | Endonuclease | Ribonucleic acid--RNA
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2012, Volume 19, Issue 8, pp. 744 - 753
In the final steps of yeast ribosome synthesis, immature translation-incompetent pre-40S particles that contain 20S pre-rRNA are converted to the mature... 
PROTEIN | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | FACTOR EIF5B | SACCHAROMYCES-CEREVISIAE | INTERNAL TRANSCRIBED SPACER-1 | PIN DOMAIN | CELL BIOLOGY | YEAST | BIOPHYSICS | BIOGENESIS | CYTOPLASMIC MATURATION | RNA Precursors - chemistry | Ribosome Subunits, Small, Eukaryotic - chemistry | Eukaryotic Initiation Factor-2 - chemistry | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Guanosine Triphosphate - metabolism | RNA, Ribosomal - genetics | Saccharomyces cerevisiae - metabolism | Ribosome Subunits, Large, Eukaryotic - metabolism | Adenosine Triphosphate - metabolism | Base Sequence | Eukaryotic Initiation Factor-2 - metabolism | RNA Precursors - metabolism | RNA, Fungal - genetics | Nucleic Acid Conformation | Binding Sites | RNA Processing, Post-Transcriptional | Ribosome Subunits, Large, Eukaryotic - chemistry | RNA, Fungal - chemistry | RNA, Ribosomal - chemistry | Models, Molecular | RNA, Ribosomal - metabolism | Nuclear Proteins - metabolism | RNA Precursors - genetics | RNA, Fungal - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Conformation | Ribosome Subunits, Small, Eukaryotic - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Biosynthesis | Research | Molecular genetics | Genetic translation | Ribosomes | Atoms & subatomic particles | Ribonucleic acid--RNA | Yeast | Index Medicus
Journal Article
Nucleus, ISSN 1949-1034, 01/2019, Volume 10, Issue 1, pp. 21 - 32
The exosome functions to regulate the cellular transcriptome through RNA biogenesis, surveillance, and decay. Mutations in Dis3, a catalytic subunit of the RNA... 
genome instability