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Alternative and Complementary Therapies, ISSN 1076-2809, 04/2018, Volume 24, Issue 2, pp. 91 - 98
The many herbal options for patients with anxiety are discussed, focusing initially on Piper methysticum (kava) as one of the most well-researched options in... 
Herbal medicine | Kava | Anxiety | Piper methysticum | Kavapyrones
Journal Article
1987, Monograph/Australian National University, North Australia Research Unit., ISBN 9780731501311, v, 49
Book
PLOS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6
Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest... 
ETOMIDATE | PIPER-METHYSTICUM | DELTA-SUBUNIT | IN-VITRO | INHIBITION | KAVALACTONES | ENRICHED EXTRACT | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | BRAIN | PROPOFOL
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2017, Volume 60, Issue 18, pp. 7935 - 7940
(+)-Dihydromethysticin was recently identified as a promising, lung cancer chemopreventive agent, while (+)-dihydrokavain was completely ineffective. A pilot... 
PIPER-METHYSTICUM | KAVA | METABOLITES | CHEMISTRY, MEDICINAL | CARCINOGENESIS | NITROSAMINES | CANCER STATISTICS | IDENTIFICATION | TUMORIGENESIS | MOUSE LUNG | TOBACCO
Journal Article
E3S Web of Conferences, ISSN 2267-1242, 12/2018, Volume 73, p. 6015
The application of various agricultural technologies such as the using by fertilizers, pesticides, and clearing land will have resulted changes in the... 
Botanical insecticide | Mortality | Piper methysticum | mortality | botanical insecticide
Conference Proceeding
by Wang, PC and Zhu, JJ and Shehu, AI and Lu, J and Chen, J and Zhong, XB and Ma, XC
CHEMICAL RESEARCH IN TOXICOLOGY, ISSN 0893-228X, 07/2019, Volume 32, Issue 7, pp. 1335 - 1342
Kavain is an active and major component in Piper methysticum Forst. (kava), which is a widely used dietary supplement for the treatment of anxiety, insomnia,... 
CHEMISTRY, MEDICINAL | KAVALACTONES | DIETARY-SUPPLEMENTS | INVOLVEMENT | TOXICITY | CYP2C19 | CHEMISTRY, MULTIDISCIPLINARY | PIPER-METHYSTICUM | CYTOCHROME-P450 ENZYMES | TOXICOLOGY | URINARY METABOLITES | HEPATOTOXICITY | EXTRACTS
Journal Article
CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 05/2005, Volume 77, Issue 5, pp. 415 - 426
Objectives. Phytochemical-mediated modulation of cytochrome P450 (CYP) activity may underlie many herb-drug interactions. Single-time point phenotypic... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | VITRO EVALUATION | ENZYME CATALYTIC-ACTIVITY | DRUG-INTERACTIONS | PIPER-METHYSTICUM FORST | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | HEALTHY-VOLUNTEERS | CIMICIFUGA-RACEMOSA | ECHINACEA-PURPUREA | TRITERPENE GLYCOSIDES
Journal Article
Planta Medica, ISSN 0032-0943, 10/2019, Volume 85, Issue 14/15, pp. 1136 - 1142
Abstract Monoamine oxidases (MAOs) are key metabolic enzymes for neurotransmitter and dietary amines and are targets for the treatment of neuropsychiatric and... 
Biological and Pharmacological Activity | SITE | kavain | CHEMISTRY, MEDICINAL | ENRICHED EXTRACT | MITOCHONDRIAL | Piperaceae | HIGH-POTENCY | inhibition | CARDIAC DYSFUNCTION | Piper methysticum | PLANT SCIENCES | kava | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | yangonin | BINDING | monoamine oxidase | PARKINSONS-DISEASE
Journal Article
Phytotherapy research : PTR, ISSN 0951-418X, 12/2012, Volume 26, Issue 12, pp. 1934 - 1941
Kava (‘Awa) is a traditional water-based beverage in Pacific island communities, prepared from the ground root and stems of Piper methysticum . Kava use is... 
kava dermopathy | Kava | Piper methysticum | mast cells | kavalactones
Journal Article
Planta Medica, ISSN 0032-0943, 11/2018, Volume 84, Issue 16, pp. 1213 - 1218
Abstract Piper methysticum (Kava) is a plant whose roots are used in the preparation of traditional beverages with spiritual, medicinal, and social importance... 
Natural Product Chemistry and Analytical Studies | kava | quality control | kavalactones | single-laboratory validation | Piperaceae | flavokavains | Piper methysticum | HPLC-UV | CHEMISTRY, MEDICINAL | CHROMATOGRAPHY | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY
Journal Article
MOLECULES, ISSN 1420-3049, 03/2019, Volume 24, Issue 7, p. 1245
An ultra-high-performance liquid chromatographic (UHPLC) separation was developed for six kava pyrones (methysticin, dihydromethysticin (DHM), kavain,... 
Piper methysticum (kava) | quality control | LIQUID-CHROMATOGRAPHY | LACTONES | kavalactones | isomerization | single-laboratory validation | BIOCHEMISTRY & MOLECULAR BIOLOGY | mass spectra | flavokavains | UHPLC-UV | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Organic Letters, ISSN 1523-7060, 08/2009, Volume 11, Issue 16, pp. 3642 - 3645
A highly efficient palladium-catalyzed Heck reaction of allylic esters with arenediazonium salts is described. The reaction proceeds under mild conditions,... 
ARYL BROMIDES | PIPER-METHYSTICUM | CINNAMYL ALCOHOLS | IODONIUM SALTS | KAVA-KAVA | DIAZONIUM SALTS | PALLADIUM-CATALYZED ARYLATION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | IONIC LIQUIDS | METHYL-ESTER
Journal Article
Planta Medica, ISSN 0032-0943, 08/2017, Volume 83, Issue 12/13, pp. 1053 - 1057
Abstract A fast and validated supercritical fluid chromatography method for the quantitative determination of major lactones in Piper methysticum , a plant... 
Natural Product Chemistry and Analytical Studies | Piperaceae | supercritical fluid chromatography | Piper methysticum | kavalactones | EXTRACTION | CHEMISTRY, MEDICINAL | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | MICE | QUALITY-CONTROL | DIHYDROMETHYSTICIN | PLANT SCIENCES | Usage | Research | Kava plant | Chromatography | Lactones
Journal Article
American family physician, ISSN 0002-838X, 07/2017, Volume 96, Issue 2, pp. 101 - 107
Journal Article
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