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PloS one, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, pp. e0168505 - e0168505
We previously reported in atrial myocytes that inhibition of cAMP-dependent protein kinase (PKA) by laminin (LMN... 
Group IV Phospholipases A2 - genetics | Mitogen-Activated Protein Kinase Kinases - genetics | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Group IV Phospholipases A2 - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Female | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - metabolism | Cats | Heart Atria - cytology | Proto-Oncogene Proteins c-raf - genetics | Receptors, Adrenergic, beta-2 - genetics | Cells, Cultured | Signal Transduction - genetics | Proto-Oncogene Proteins c-raf - metabolism | Receptors, Adrenergic, beta-2 - metabolism | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Calcium Signaling - drug effects | Myocytes, Cardiac - metabolism | Signal Transduction - physiology | Calcium Signaling - genetics | Carbazoles - pharmacology | Inositol 1,4,5-Trisphosphate Receptors - genetics | Zinterol | Protein kinase A | Phosphorylation | Protein kinase C | Embolisms | Chelerythrine | Raf protein | Stimulation | Biochemistry | Cyclodextrins | Myocytes | Kinases | Experiments | Western blotting | Calcium signalling | Proteins | Adenylate cyclase | Thapsigargin | Laminin | Rodents | Aging | Physiology | Inhibition | Inositol 1,4,5-trisphosphate | Inositol 1,4,5-trisphosphate receptors | Heart failure | Medical research | Calcium (intracellular) | Phospholipase A2 | Caveolae | Extracellular signal-regulated kinase | Cyclic AMP | Programmable logic controllers | Cardiomyocytes | Pharmacology | Phospholipase C | Phospholipase | Cyclodextrin | Ostomy | Programmable logic devices | Adrenergic receptors | Cancer | Index Medicus
Journal Article
Cellular signalling, ISSN 0898-6568, 12/2012, Volume 24, Issue 12, pp. 2396 - 2406
...) dependent protein kinase (PKA) plays a role in this process. We found that hypoxia increased PKA activity and induced mRNA and protein expression of PKA catalytic subunit α (PKACA... 
Hypoxia inducible factor | Lung cancer | Migration | Invasion | PKA | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - metabolism | Epithelial-Mesenchymal Transition - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Lung Neoplasms - pathology | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - genetics | Cell Hypoxia | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Isoquinolines - pharmacology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - antagonists & inhibitors | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Transforming Growth Factor beta1 - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Colforsin - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Sulfonamides - pharmacology | Up-Regulation - drug effects | Cell Movement - drug effects | Animals | Cell Line, Tumor | Mice | RNA, Small Interfering - metabolism | Chemical inhibitors | Messenger RNA | Gene expression | Protein kinases | Cancer cells | Index Medicus | Proteins | Inhibitors | Lungs | Hypoxia | Activation | Kinases | Cancer
Journal Article
Biochemical journal, ISSN 1470-8728, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | drug discovery | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | inhibitor specificity | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | anti-cancer drugs | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | protein kinase | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | kinase profiling | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), PKC, S6K p70 (ribosomal S6 kinase), RSK... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 9, pp. 2391 - 2402
...) subunit phosphorylation. The scaffolding molecule A-kinase anchoring protein ( AKAP) 79/150 targets both the cAMP-dependent protein kinase (PKA... 
AMPA receptor | FRET | A-kinase anchoring proteins | LTD | PKA | Synaptic plasticity | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Disks Large Homolog 4 Protein | Phosphorylation | Age Factors | Receptors, N-Methyl-D-Aspartate - metabolism | Cytoplasm - metabolism | Male | Neurons - cytology | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Long-Term Synaptic Depression - drug effects | N-Methylaspartate - pharmacology | Drug Interactions | Synapses - metabolism | Transfection - methods | Time Factors | Neurons - physiology | Membrane Proteins - metabolism | Animals, Newborn | Dendrites - metabolism | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Blotting, Western - methods | Valine - analogs & derivatives | Cells, Cultured | Rats | Excitatory Amino Acid Agonists - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Serine - metabolism | Gene Expression Regulation - drug effects | Cyclic AMP-Dependent Protein Kinases - physiology | Animals | Analysis of Variance | Mutagenesis | A Kinase Anchor Proteins | Bacterial Proteins - metabolism | Enzyme Activation | Valine - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Cytoplasm - drug effects | Long-Term Synaptic Depression - radiation effects | Calcineurin - metabolism | Luminescent Proteins - metabolism | Index Medicus | synaptic plasticity
Journal Article