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Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 47, pp. 33966 - 33977
Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of... 
MAMMALIAN TARGET | DUAL-SPECIFICITY PHOSPHATASE-1 | Signal Transduction | PHOSPHORYLATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | Akt PKB | MTOR | CROSS-TALK | MAP Kinases (MAPKs) | mTOR Complex (mTORC) | IMMUNE-RESPONSES | Dual Specificity Phosphoprotein Phosphatase | INFLAMMATORY RESPONSE | T-CELLS | Antibiotics, Antineoplastic - pharmacology | TOR Serine-Threonine Kinases - metabolism | Bone Marrow Cells - enzymology | Activating Transcription Factor 2 - genetics | Proto-Oncogene Proteins c-akt - genetics | CREB-Binding Protein - genetics | Dose-Response Relationship, Drug | MAP Kinase Kinase 1 - genetics | CREB-Binding Protein - metabolism | Phosphorylation - genetics | MAP Kinase Signaling System - genetics | TOR Serine-Threonine Kinases - genetics | Enzyme Induction - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Dual Specificity Phosphatase 1 - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | MAP Kinase Kinase 2 - genetics | Activating Transcription Factor 1 - genetics | Cell Line | Dual Specificity Phosphatase 1 - genetics | Lipopolysaccharides - toxicity | Interleukin-6 - genetics | Bone Marrow Cells - cytology | Activating Transcription Factor 1 - metabolism | Morpholines - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Macrophages - cytology | Enzyme Activation - drug effects | Sirolimus - pharmacology | Activating Transcription Factor 2 - metabolism | Macrophages - enzymology | Mice, Knockout | Enzyme Induction - genetics | Animals | MAP Kinase Signaling System - drug effects | Nitric Oxide - genetics | Mice | Enzyme Activation - genetics | Nitric Oxide - metabolism | Index Medicus | Immunology
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 06/2018, Volume 218, Issue 1, pp. 152 - 164
Background. In Schistosoma mansoni, the facilitated glucose transporter SGTP4, which is expressed uniquely in the apical surface tegumental membranes of the... 
Schistosoma mansoni | Akt | schistosomiasis | glucose transporter protein | SGTP4 | CERCARIAE | INFECTIOUS DISEASES | TRANSPORTER | AKT/PKB | PROTEIN-KINASE | MICROBIOLOGY | IMMUNOLOGY | TEGUMENT | SURFACE | INHIBITORS | Index Medicus | Abridged Index Medicus | Major and Brief Reports
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 28, pp. 24553 - 24560
Protein kinase B (PKB, Akt) is a Ser/Thr kinase involved in the regulation of cell survival, proliferation, and metabolism and is activated by dual... 
MAMMALIAN TARGET | INSULIN | SUBSTRATE-SPECIFICITY | RAPAMYCIN MTOR | ACTIVATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RICTOR | MICE | INHIBITOR | AGGREGATION | Adipocyte | mTOR Complex (mTORC) | Platelet | Signal Transduction | PI 3-Kinase | PRAS40 | Glycogen Synthase Kinase 3 | p70S6 Kinase | Akt PKB | Insulin | Insulin-like Growth Factor (IGF)
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, pp. e0215871 - e0215871
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2018, Volume 293, Issue 29, pp. 11388 - 11400
The role of albumin reabsorption in proximal tubule (PT) cells has emerged as an important factor in the genesis of albuminuria observed in the early stages of... 
MAMMALIAN TARGET | APOPTOSIS | GLCNAC | signal transduction | MTOR COMPLEXES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | ANGIOTENSIN-II | Akt PKB | kidney | megalin expression | high glucose | EPITHELIAL-CELLS | ROLES | O-GlcNAcylation | proximal tubule | REABSORPTION | albumin endocytosis | diabetic nephropathy | LINKED N-ACETYLGLUCOSAMINE | mTOR complex (mTORC) | Index Medicus | Signal Transduction
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/1999, Volume 19, Issue 8, pp. 5800 - 5810
Journal Article
Journal Article
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, ISSN 1357-2725, 09/2016, Volume 78, pp. 63 - 74
The Protein kinase B (AKT) regulates a plethora of intracellular signaling proteins to fine-tune signaling of multiple pathways. Here, we found that following... 
14-3-3 | NUCLEAR IMPORT | AKT/PKB | SYK | PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | SIGNALING PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Importin 7 | CELL DEVELOPMENT | AUTOPHOSPHORYLATION SITE | CELL BIOLOGY | BRUTONS TYROSINE KINASE | Nuclear translocation | MESSENGER-RNA | ANTIGEN-RECEPTOR | BLNK | LINKER PROTEIN | PHLPP
Journal Article
CURRENT CANCER DRUG TARGETS, ISSN 1568-0096, 2018, Volume 18, Issue 9, pp. 830 - 846
Background: Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/threonine kinases with three structurally homologous mammalian... 
selectivity | Protein kinase B | PKB INHIBITORS | PLECKSTRIN-HOMOLOGY-DOMAIN | CRYSTAL-STRUCTURE | MOLECULAR DOCKING | POTENT INHIBITORS | Akt inhibitors | ALLOSTERIC INHIBITORS | BREAST-CANCER | ONCOLOGY | SIGNALING PATHWAY | cell apoptosis | BIOLOGICAL EVALUATION | rational molecular design | NF-KAPPA-B | PH domain
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 25, pp. 22017 - 22027
Pkh1, -2, and -3 are the yeast orthologs of mammalian 3-phosphoinositide- dependent protein kinase-1 (PDK1). Although essential for viability, their... 
AGC KINASES | CATALYTIC SUBUNIT | PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | BINDING POCKET | SACCHAROMYCES-CEREVISIAE | ADENYLATE-CYCLASE | RAS PROTEINS | DOCKING SITE | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Cyclic AMP-Dependent Protein Kinases - chemistry | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae Proteins - biosynthesis | Saccharomyces cerevisiae - metabolism | Nitrogen - pharmacology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Catalytic Domain | Proto-Oncogene Proteins c-akt - chemistry | Protein-Serine-Threonine Kinases - genetics | Cell Size | Saccharomyces cerevisiae Proteins - genetics | Protein-Serine-Threonine Kinases - biosynthesis | Saccharomyces cerevisiae - cytology | Sequence Homology, Amino Acid | Animals | Mutagenesis | Saccharomyces cerevisiae Proteins - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Saccharomyces cerevisiae - enzymology | Protein-Serine-Threonine Kinases - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus | Site-directed Mutagenesis | Protein Kinase A (PKA) | Yeast | Signal Transduction | Protein Kinases | PKB | Sch9 | Protein Phosphorylation | Saccharomyces cerevisiae | PDK1 | Pkh1–3
Journal Article
Journal Article