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pkcθ (91) 91
index medicus (84) 84
pkc theta (64) 64
humans (55) 55
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Journal of Experimental Medicine, ISSN 0022-1007, 07/2004, Volume 200, Issue 2, pp. 181 - 189
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 02/2009, Volume 19, Issue 3, pp. 766 - 769
Thieno[2,3-b]pyridine-5-carbonitrile 16 with a 4-methyl-5-indolylamine at C-4 and a 5-methoxy-2-(dimethylamino)-methylphenyl group at C-2 had an IC value of 16... 
Thieno[2,3-b]pyridine-5-carbonitrile | PKCθ
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue 21, pp. 2395 - 2412
BACKGROUND:Although the role of thrombin in atherothrombosis is well studied, its role in the pathogenesis of diet-induced atherosclerosis is not known.... 
atherosclerosis | macrophages | thrombin | PKCθ | G protein-coupled receptor signaling | foam cell | CD36
Journal Article
Modern Pathology, ISSN 0893-3952, 06/2011, Volume 24, Issue 6, pp. 866 - 875
  Pathological diagnosis of gastrointestinal stromal tumors (GISTs) is based on histological findings and immunohistochemical demonstration of the KIT protein.... 
diagnosis | PKC-θ | gastrointestinal stromal tumor | DOG1 | therapy | KIT
Journal Article
Annual Review of Immunology, ISSN 0732-0582, 2002, Volume 20, pp. 761 - 794
Journal Article
European Journal of Immunology, ISSN 0014-2980, 07/2004, Volume 34, Issue 7, pp. 2001 - 2011
Journal Article
Cancer cell, ISSN 1535-6108, 2/2013, Volume 23, Issue 2, pp. 228 - 237
The natural product englerin A (EA) binds to and activates protein kinase C-θ (PKCθ). EA-dependent activation of PKCθ induces an insulin resistant phenotype,... 
renal cell cancer | PKCθ | HSF1 | englerin A | insulin resistance
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2012, Volume 3, pp. 197 - 197
Protein kinase C (PKC)-theta is a serine/threonine kinase belonging to the calcium-independent novel PKC subfamily; its expression is restricted to certain... 
TCR signaling | PKC-Θ | phosphorylation | PKC-theta | IMMUNOLOGY | PKC-θ | Phosphorylation | NF-kappa B | GLK
Journal Article
OncoImmunology, ISSN 2162-4011, 12/2012, Volume 1, Issue 9, pp. 1460 - 1468
Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) alters inflammation and favors T-cell tolerance in cancer, but the underlying molecular mechanisms... 
amino acid starvation | immunomodulation | autophagy | IDO | stress signaling | mTOR | S6K | PKC-θ | IDO2 | TDO | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Stress signaling | Immunomodulation | Amino acid starvation | Autophagy | MTOR | PKC-theta | INDOLEAMINE 2,3-DIOXYGENASE | KINASE | IMMUNOLOGY | SUPPRESSION | CANCER | ONCOLOGY | TRANSFER-RNA SYNTHETASE | INFLAMMATION | IN-VIVO | REGULATORY T-CELLS | DIFFERENTIATION | Research Paper
Journal Article
Molecular Informatics, ISSN 1868-1743, 09/2012, Volume 31, Issue 9, pp. 659 - 668
In the present study, 3D-QSAR analysis was performed on a set of 56 amino pyrimidine PKC-θ inhibitors utilizing docking based alignment. The best 3D-QSAR model... 
3D-QSAR | Docking | Amino pyridine inhibitors | Inflammation, PKC-θ
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2012, Volume 3, pp. 273 - 273
Protein kinase C-theta (PKC theta) is a key enzyme in T lymphocytes, where it plays an important role in signal transduction downstream of the activated T cell... 
CD28 | Protein kinase C-theta | Signal transduction | Costimulation | Lck | PKCΘ | protein kinase C-theta | costimulation | signal transduction | IMMUNOLOGY | PKC theta | Signal Transduction | Protein kinase C theta | PKCθ
Journal Article
Journal of Pathology, ISSN 0022-3417, 03/2018, Volume 244, Issue 3, pp. 323 - 333
Chronic muscle inflammation is a critical feature of Duchenne muscular dystrophy and contributes to muscle fibre injury and disease progression. Although... 
mdx | PKC-theta | muscular dystrophy | inflammation | necrosis | PKCθ | Prkcq | T cells | FIBROSIS | IMMUNE-RESPONSE | MDX MOUSE | KINASE-C-THETA | PERFORIN-MEDIATED CYTOTOXICITY | PATHOLOGY | PKC theta | SKELETAL-MUSCLE | DEFICIENT MUSCLE | ONCOLOGY | MICE | CORTICOSTEROID TREATMENT | LYMPHOCYTE DEPLETION | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2009, Volume 124, Issue 7, pp. 1605 - 1613
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 02/2019, Volume 82, pp. 33 - 40
Six new ( – ) and nine known ( – ) staurosporine derivatives were isolated from the rice solid fermentation of the marine-derived sp. NB-A13. Compound... 
PKC-θ inhibitor | Cytotoxicity | Staurosporine derivatives | CGP 41251 | TRIAL | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PKC-theta inhibitor | INHIBITOR | Index Medicus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 4/2011, Volume 31, Issue 4, pp. 921 - 927
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2018, Volume 26, Issue 20, pp. 5499 - 5509
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 05/2018, Volume 1860, Issue 5, pp. 1046 - 1056
The PKC isozymes represent the most prominent family of signaling proteins mediating response to the ubiquitous second messenger diacylglycerol. Among them,... 
PMA | PKCθ | Phorbol ester | Diacylglycerol | Binding affinity | Membrane translocation | C1a domain | PKCO | ACTIVATION | MECHANISM | CRYSTAL-STRUCTURE | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cla domain | IDENTIFICATION | BIOPHYSICS | AFFINITY | REGULATORY DOMAIN | GASTROINTESTINAL STROMAL TUMORS | CELL | PKC-THETA | Phorbol esters | T cells | Isoenzymes | Protein kinases | Index Medicus
Journal Article
Endocrine, metabolic & immune disorders drug targets, ISSN 1871-5303, 2010, Volume 10, Issue 4, pp. 367 - 372
Journal Article
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