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Cancer Research, ISSN 0008-5472, 08/2005, Volume 65, Issue 16, pp. 7462 - 7469
Activation of protein kinase C beta (PKC beta) has been repeatedly implicated in tumor-induced angiogenesis. The PKC beta-selective inhibitor, Enzastaurin... 
ACTIVATION | CARCINOGENESIS | ANTICANCER | ONCOLOGY | PHOSPHORYLATION | GLYCOGEN-SYNTHASE KINASE-3 | PKC-BETA | EXPRESSION | PROGRESSION
Journal Article
Tetrahedron, ISSN 0040-4020, 10/2015, Volume 71, Issue 42, pp. 7990 - 7997
The first synthesis of fradcarbazole A ( ) has been accomplished by using a biomimetic intramolecular cyclization/dehydration to construct the... 
Cytotoxicity | PKC-Beta | Fradcarbazole A | Staurosporine | Biomimetic synthesis | THIOUREAS | POTENT | ASSAY | BIOLOGY | CHEMISTRY | CHEMISTRY, ORGANIC | DERIVATIVES | Oxazoles
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 08/2003, Volume 14, Issue 90003, pp. S227 - S232
Hyperglycemia seems to be an important causative factor in the development of micro- and macrovascular complications in patients with diabetes. Several... 
REDUCTASE INHIBITORS | OXIDATIVE STRESS | ENDOTHELIAL DYSFUNCTION | PKC-BETA INHIBITOR | WHOLE MICE | DNA-DAMAGE | UROLOGY & NEPHROLOGY | SMOOTH-MUSCLE-CELLS | NADH-OXIDASE | SUPEROXIDE PRODUCTION | DIACYLGLYCEROL SYNTHESIS
Journal Article
by Lee, HI and Lee, J and Hwang, D and Lee, GR and Kim, N and Kwon, M and Lee, H and Piao, D and Kim, HJ and Kim, NY and Kim, HS and Seo, EK and Kang, D and Jeong, W
FASEB JOURNAL, ISSN 0892-6638, 08/2019, Volume 33, Issue 8, pp. 9685 - 9694
Excessive osteoclast activity can lead to an imbalance between the synthesis and breakdown of bone, with pathologic consequences that include osteoporosis and... 
TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | bone | PROLIFERATION | MECHANISMS | CELL BIOLOGY | BONE LOSS | BIOGENESIS | BIOLOGY | PKC-beta | NUCLEAR FACTOR | DYSFUNCTION | integrin | PROTEINS | EXPRESSION | Atg5 | T-CELLS | Index Medicus
Journal Article
CIRCULATION RESEARCH, ISSN 0009-7330, 08/2013, Volume 113, Issue 4, pp. 418 - 427
Rationale: Loss of insulin action in the endothelium can cause endothelial dysfunction and atherosclerosis. Hyperglycemia and elevated fatty acids induced by... 
atherosclerosis | endothelium | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PKC-BETA | DIABETIC-RATS | INHIBITION | GLUCOSE | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | GROWTH-FACTOR | OUTCOMES | E NULL MICE | HEMATOLOGY | insulin resistance | protein kinase C
Journal Article
CELL CYCLE, ISSN 1538-4101, 02/2019, Volume 18, Issue 4, pp. 395 - 412
PKC beta I, a member of the classical protein kinase C family, plays key roles in regulating cell cycle transition. Here, we report the expression,... 
PROTEIN-KINASE-C | ACTIVATION | meiosis | MEIOSIS RESUMPTION | M-PHASE | DIFFERENTIAL LOCALIZATION | PKC beta 1 | CELL BIOLOGY | oocyte | SPINDLE ORGANIZATION | CHROMOSOME SEGREGATION | spindle | germinal vesicle breakdown | PROGRESSION | POLAR-BODY EMISSION | NUCLEAR ACTIVITY
Journal Article
by Lei, SQ and Zhang, Y and Su, WT and Zhou, L and Xu, JJ and Xia, ZY
LIFE SCIENCES, ISSN 0024-3205, 11/2018, Volume 213, pp. 109 - 115
Aim: Lipopolysaccharide (LPS)-induced myocardial injury is a leading cause of death in patients with sepsis, which is associated with excessive activation of... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | Cardiomyocytes | SEPTIC CARDIOMYOPATHY | PKC-BETA | SEPSIS | PKC beta 2 | Autophagy | Remifentanil | INDUCED CARDIAC DYSFUNCTION | SIGNALING PATHWAY | LPS-INDUCED AUTOPHAGY | IN-VIVO | Lipopolysaccharide | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | STRESS
Journal Article
Journal Article
by Lee, KW and Kim, SG and Kim, HP and Kwon, E and Yons, J and Choi, HJ and Park, JH and Kang, BC and Im, SA and Kim, TY and Kim, WH and Bang, YJ
CANCER RESEARCH, ISSN 0008-5472, 03/2008, Volume 68, Issue 6, pp. 1916 - 1926
Activation of protein kinase C (PKC) has been implicated in gastric carcinogenesis. Enzastaurin is an oral ATP-competitive inhibitor of the PKC beta isozyme.... 
MULTIPLE-MYELOMA | SURVIVAL | IN-VITRO | ONCOLOGY | PHOSPHORYLATION | CELL INVASION | AKT PATHWAY | PKC-BETA | DEPENDENT PATHWAY | GROWTH-FACTOR | EXPRESSION
Journal Article
by Guo, K and Liu, YK and Zhou, HJ and Dai, Z and Zhang, J and Sun, RX and Chen, J and Sun, QL and Lu, WJ and Kang, XN and Chen, P
CANCER SCIENCE, ISSN 1347-9032, 03/2008, Volume 99, Issue 3, pp. 486 - 496
To understand the molecular mechanism that underlies the role of various prominent signal pathways in hepatocellular carcinoma (HCC) metastasis, a human signal... 
SIGNAL-TRANSDUCTION | APOPTOSIS | METASTASIS | ONCOLOGY | GROWTH | P38 MAPK | PKC-BETA | AKT PATHWAY | INHIBITOR | CANCER | HEAT-SHOCK-PROTEIN
Journal Article