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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 2, pp. 388 - 396
Inhibition of prostaglandin E signaling via EP2/EP4 prostanoid receptors suppresses Insulin-like growth factor (IGF)-1-induced proliferation of pancreatic... 
BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | INVOLVEMENT | C7ORF24 | COLON | BINDING PROTEIN-3 | PKC-THETA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2008, Volume 283, Issue 22, pp. 15370 - 15380
Autophagy is an evolutionally conserved process for the bulk degradation of cytoplasmic proteins and organelles. Recent observations indicate that autophagy is... 
SURVIVAL | APOPTOSIS | OBESITY | PHOSPHORYLATION | PATHWAY | INSULIN-RESISTANCE | ER STRESS | ACTIVATION LOOP | BIOCHEMISTRY & MOLECULAR BIOLOGY | PKC-THETA | CELL-DEATH
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6199 - 6206
Notch3 overexpression has been previously shown to positively regulate the generation and function of naturally occurring regulatory T cells and the expression... 
ACTIVATION | TCR | PERIPHERY | RECEPTOR | LEUKEMIA | IMMUNOLOGY | T-CELL DEVELOPMENT | EXPRESSION | PKC-THETA | TRANSGENIC MICE | LYMPHOCYTES
Journal Article
Immunity, ISSN 1074-7613, 2005, Volume 23, Issue 6, pp. 575 - 585
CARMA1 mediates T cell receptor (TCR)-induced NF-κB activation. However, how TCR links to CARMA1 in the signaling pathway is not clear. Here, we show that... 
RECRUITMENT | KINASE-C-THETA | IMMUNE-RESPONSES | FAMILY MEMBER | COSTIMULATION | BCL10 | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | LYMPHOCYTE-ACTIVATION | PKC-THETA | ANTIGEN
Journal Article
Journal Article
JNCCN Journal of the National Comprehensive Cancer Network, ISSN 1540-1405, 04/2010, Volume 8, Issue 2, pp. S1 - S40
The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly... 
Abdominal tumor | PDGFRA | GIST | Imatinib | NCCN | Gastric mass | Gene expression profiling | TKIs | Gastrointestinal tract | Wild-type GISTs | Stomach cancer | Tyrosine kinase inhibitors | Gastrointestinal stromal tumor | Sunitinib | GEP | KIT | CD117 | Small bowel tumor | Liver metastasis | gastrointestinal tract | PKC-THETA EXPRESSION | POTENTIAL THERAPEUTIC TARGET | TYROSINE-KINASE INHIBITOR | tyrosine kinase inhibitors | small bowel tumor | IMATINIB MESYLATE THERAPY | sunitinib | liver metastasis | ADVANCED SOLID TUMORS | CARNEY-STRATAKIS-SYNDROME | PROGRESSION-FREE SURVIVAL | imatinib | abdominal tumor | POPULATION-BASED INCIDENCE | POSITRON-EMISSION-TOMOGRAPHY | gastrointestinal stromal tumor | stomach cancer | ONCOLOGY | gastric mass | TERM-FOLLOW-UP | gene expression profiling | wild-type GISTs | Piperazines - administration & dosage | Prognosis | Humans | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Antineoplastic Agents - administration & dosage | Biomarkers, Tumor | Indoles - administration & dosage | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Pyrroles - administration & dosage | Gastrointestinal Stromal Tumors - pathology | Pyrroles - adverse effects | Pyrroles - therapeutic use | Pyrimidines - administration & dosage | Piperazines - therapeutic use | Imatinib Mesylate | Piperazines - adverse effects | Diagnostic Imaging | Gastrointestinal Stromal Tumors - therapy | Indoles - adverse effects | Pyrimidines - therapeutic use | Pyrimidines - adverse effects | Indoles - therapeutic use | Benzamides
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2012, Volume 3, pp. 197 - 197
Protein kinase C (PKC)-theta is a serine/threonine kinase belonging to the calcium-independent novel PKC subfamily; its expression is restricted to certain... 
TCR signaling | PKC-Θ | phosphorylation | PKC-theta | IMMUNOLOGY | PKC-θ | Phosphorylation | NF-kappa B | GLK
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/2007, Volume 26, Issue 22, pp. 4634 - 4645
Triggering of antigen receptors on lymphocytes is critical for initiating adaptive immune response against pathogens. T‐cell receptor (TCR) engagement induces... 
NF‐κB | regulatory ubiquitination | Malt1 | T‐cell signaling | NF-κB | Regulatory ubiquitination | T-cell signaling | PHOSPHORYLATION | CARMA1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | BCL10 | CELL BIOLOGY | REGULATOR | kappa B | PATHWAY | IMMUNE-RESPONSES | ANTIGEN-RECEPTOR | malt1 | LYMPHOCYTE-ACTIVATION | PKC-THETA
Journal Article
OncoImmunology, ISSN 2162-4011, 12/2012, Volume 1, Issue 9, pp. 1460 - 1468
Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) alters inflammation and favors T-cell tolerance in cancer, but the underlying molecular mechanisms... 
amino acid starvation | immunomodulation | autophagy | IDO | stress signaling | mTOR | S6K | PKC-θ | IDO2 | TDO | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Stress signaling | Immunomodulation | Amino acid starvation | Autophagy | MTOR | PKC-theta | INDOLEAMINE 2,3-DIOXYGENASE | KINASE | IMMUNOLOGY | SUPPRESSION | CANCER | ONCOLOGY | TRANSFER-RNA SYNTHETASE | INFLAMMATION | IN-VIVO | REGULATORY T-CELLS | DIFFERENTIATION | Research Paper
Journal Article
ACS medicinal chemistry letters, ISSN 1948-5875, 08/2019, Volume 10, Issue 8, pp. 1134 - 1139
PKCθ plays an important role in T cell biology and is a validated target for a number of disease states. A series of potent and selective PKCθ inhibitors were... 
ACTIVATION | CHEMISTRY, MEDICINAL | kinases | PKC-THETA INHIBITORS | multiple sclerosis | C-THETA | OPTIMIZATION | AEB071 | PKC theta | CELL | oxetane | SOTRASTAURIN
Journal Article
by Bai, XM and Wang, J and Guo, Y and Pan, JS and Yang, QY and Zhang, M and Li, H and Zhang, L and Ma, J and Shi, F and Shu, W and Wang, YP and Leng, J
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2014, Volume 4
Prostaglandin E-2 (PGE(2)) has been implicated in cell invasion in hepatocellular carcinoma (HCC), via increased beta 1-integrin expression and cell migration;... 
MIGRATION | GROWTH-FACTOR RECEPTOR | ACTIVATION | SIGNALING PATHWAY | INTEGRIN | MULTIDISCIPLINARY SCIENCES | C-ALPHA | PROTEIN KINASE/ERK PATHWAY | EXTRACELLULAR-MATRIX | LUNG-CANCER CELLS | PKC-THETA
Journal Article