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animals (152) 152
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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2014, Volume 457, Issue 3, pp. 451 - 461
PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5... 
Histone deacetylase | Signal transduction | Four-and-a-half LIM (FHL) | Cardiac myocyte | Neurohormonal stimulation | Protein kinase | four-and-a-half LIM (FHL) | PRESSURE-OVERLOAD | HISTONE-DEACETYLASE KINASE | neurohormonal stimulation | signal transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | FHL2 | NUCLEAR EXPORT | CARDIOMYOCYTES | histone deacetylase | cardiac myocyte | protein kinase | TROPONIN-I | HYPERTROPHIC RESPONSE | GENE-EXPRESSION | METABOLIC ENZYMES | TRANSCRIPTION FACTOR | Protein Kinase C - genetics | Heart Ventricles - cytology | Phosphorylation | Transcription Factors - chemistry | LIM-Homeodomain Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | LIM-Homeodomain Proteins - antagonists & inhibitors | LIM Domain Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Peptide Fragments - genetics | LIM Domain Proteins - chemistry | Animals, Newborn | Peptide Fragments - metabolism | Myocytes, Cardiac - cytology | Endothelin-1 - metabolism | Isoenzymes - genetics | LIM-Homeodomain Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | LIM Domain Proteins - antagonists & inhibitors | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | LIM-Homeodomain Proteins - genetics | Peptide Fragments - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | LIM Domain Proteins - genetics | Heart Ventricles - metabolism | Mice | Muscle Proteins - chemistry | Protein Processing, Post-Translational | Enzyme Activation | FHL, four-and-a-half LIM domains | PKD, protein kinase D | MEF2, myocyte enhancer factor 2 | MuRF, muscle RING finger | ARVM, adult rat ventricular myocyte | ERK, extracellular-signal-regulated kinase | caPKD, constitutively active catalytic domain of PKD | BPKDi, bipyridyl PKD inhibitor | CaMK, Ca2 | PE, phenylephrine | HDAC, histone deacetylase | calmodulin-dependent protein kinase | PKC, protein kinase C | cMyBP-C, cardiac myosin-binding protein C | IVK, in vitro kinase | TAC, transverse aortic constriction | CRM1, chromosome region maintenance 1 | pfu, plaque-forming unit | ET1, endothelin 1 | cTnI, inhibitory subunit of cardiac troponin | MOI, multiplicity of infection | NRVM, neonatal rat ventricular myocyte
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2003, Volume 22, Issue 1, pp. 109 - 120
.... We show that tyrosine phosphorylation of protein kinase D (PKD) at Y463 in the Pleckstrin Homology (PH... 
IKK | PKD | Abl | NF‐κB | Src | NF-κB | TARGET | OXIDATIVE STRESS | INTACT-CELLS | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | FAMILY | CELL BIOLOGY | NF-kappa B | IKK-BETA SUBUNIT | IN-VIVO
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 11/2007, Volume 14, Issue 11, pp. 1908 - 1915
Journal Article
Biochemical journal, ISSN 0264-6021, 10/2013, Volume 455, Issue 2, pp. 251 - 260
.... This phosphorylation is mediated by PKD1 (protein kinase D1). Phosphorylation of PAK4 at Ser99 also mediates binding to 14-3-3 protein, and is required for the formation of a PAK4-LIMK-PKD1 complex that regulates cofilin activity and directed cell migration. 
P21-activated kinase 4 (PAK4) | 14-3-3 protein | Leading edge | Localization | Protein kinase D (PKD) | RhoGTPase | Phosphorylation | Signal Transduction | Humans | Serine - genetics | p21-Activated Kinases - metabolism | Serine - metabolism | 14-3-3 Proteins - metabolism | Transfection | Protein Kinase C - metabolism | HEK293 Cells | HeLa Cells | p21-Activated Kinases - analysis | Cell Movement
Journal Article