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Nature (London), ISSN 1476-4687, 2010, Volume 465, Issue 7296, pp. 305 - 310
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 505, Issue 7481, pp. 50 - 55
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the... 
POINT MUTATIONS | IN-VITRO | ANTIMALARIAL-DRUGS | WESTERN CAMBODIA | VIVO | PARASITE CLEARANCE | MULTIDISCIPLINARY SCIENCES | COPY NUMBER | KEAP1 | KELCH-REPEAT SUPERFAMILY | CHLOROQUINE RESISTANCE | Malaria, Falciparum - drug therapy | Parasitic Sensitivity Tests | Cambodia | Humans | Half-Life | Blood Cells - parasitology | Drug Resistance - drug effects | Protein Structure, Tertiary - genetics | Plasmodium falciparum - drug effects | Mutation - genetics | Protozoan Proteins - genetics | Antimalarials - pharmacology | Drug Resistance - genetics | Malaria, Falciparum - parasitology | Artemisinins - pharmacology | Animals | Time Factors | Genetic Markers - genetics | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Alleles | Polymorphism, Single Nucleotide - genetics | Protozoan Proteins - chemistry | Plasmodium falciparum - growth & development | Plasmodium falciparum | Drug resistance in microorganisms | Microbiological research | Physiological aspects | Research | Molecular biology | Health aspects | Medical research | Mutation | Parasites | Malaria | Genomics | Protein Structure, Tertiary | Blood Cells | Malaria, Falciparum | Antimalarials | Protozoan Proteins | Genetic Markers | Life Sciences | Human health and pathology | Infectious diseases | Artemisinins | Polymorphism, Single Nucleotide | Drug Resistance
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 542, Issue 7642, pp. 445 - 449
Journal Article
by Ménard, Didier and Khim, Nimol and Beghain, Johann and Adegnika, Ayola A and Shafiul-Alam, Mohammad and Amodu, Olukemi and Rahim-Awab, Ghulam and Barnadas, Céline and Berry, Antoine and Boum, Yap and Bustos, Maria D and Cao, Jun and Chen, Jun-Hu and Collet, Louis and Cui, Liwang and Thakur, Garib-Das and Dieye, Alioune and Djallé, Djibrine and Dorkenoo, Monique A and Eboumbou-Moukoko, Carole E and Espino, Fe-Esperanza-Caridad J and Fandeur, Thierry and Ferreira-da-Cruz, Maria-Fatima and Fola, Abebe A and Fuehrer, Hans-Peter and Hassan, Abdillahi M and Herrera, Socrates and Hongvanthong, Bouasy and Houzé, Sandrine and Ibrahim, Maman L and Jahirul-Karim, Mohammad and Jiang, Lubin and Kano, Shigeyuki and Ali-Khan, Wasif and Khanthavong, Maniphone and Kremsner, Peter G and Lacerda, Marcus and Leang, Rithea and Leelawong, Mindy and Li, Mei and Lin, Khin and Mazarati, Jean-Baptiste and Ménard, Sandie and Morlais, Isabelle and Muhindo-Mavoko, Hypolite and Musset, Lise and Na-Bangchang, Kesara and Nambozi, Michael and Niaré, Karamoko and Noedl, Harald and Ouédraogo, Jean-Bosco and Pillai, Dylan R and Pradines, Bruno and Quang-Phuc, Bui and Ramharter, Michael and Randrianarivelojosia, Milijaona and Sattabongkot, Jetsumon and Sheikh-Omar, Abdiqani and Silué, Kigbafori D and Sirima, Sodiomon B and Sutherland, Colin and Syafruddin, Din and Tahar, Rachida and Tang, Lin-Hua and Touré, Offianan A and Tshibangu-wa-Tshibangu, Patrick and Vigan-Womas, Inès and Warsame, Marian and Wini, Lyndes and Zakeri, Sedigheh and Kim, Saorin and Eam, Rotha and Berne, Laura and Khean, Chanra and Chy, Sophy and Ken, Malen and Loch, Kaknika and Canier, Lydie and Duru, Valentine and Legrand, Eric and Barale, Jean-Christophe and Stokes, Barbara and Straimer, Judith and Witkowski, Benoit and Fidock, David A and Rogier, Christophe and Ringwald, Pascal and Ariey, Frederic and Mercereau-Puijalon, Odile and KARMA Consortium
The New England journal of medicine, ISSN 1533-4406, 2016, Volume 374, Issue 25, pp. 2453 - 2464
Journal Article
The Lancet infectious diseases, ISSN 1473-3099, 2012, Volume 12, Issue 11, pp. 851 - 858
Journal Article
eLife, ISSN 2050-084X, 2016, Volume 5, Issue 2016, pp. 1 - 29
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent... 
artemisinin | evolutionary biology | infectious disease | plasmodium falciparum | microbiology | genomics | drug resistance | malaria | kelch13 | SOFT SWEEPS | PARASITES | MOLECULAR POPULATION-GENETICS | EVOLUTION | SUBSTITUTION MATRICES | SIGNATURES | MECHANISM | PLASMODIUM-FALCIPARUM | ADAPTATION | BIOLOGY | MUTATIONS | Malaria, Falciparum - parasitology | Africa - epidemiology | Artemisinins - pharmacology | Plasmodium falciparum - classification | Molecular Epidemiology | Plasmodium falciparum - genetics | Plasmodium falciparum - isolation & purification | Malaria, Falciparum - epidemiology | Plasmodium falciparum - drug effects | Asia, Southeastern - epidemiology | Drug Resistance | Antimalarials - pharmacology | Drug resistance in microorganisms | Genetic aspects | Malaria | Drug therapy | Gene expression | Health aspects | Medical research | Genomics | Artemisinin | Genomes | Parasites | Epidemiology | Medicine | Studies | Proteins | Health surveillance | Collaboration | Quality control | Genetics | Mutation | Public health | Malaria, Falciparum/parasitology | Plasmodium falciparum/genetics | Plasmodium falciparum/classification | Antimalarials/pharmacology | Plasmodium falciparum/drug effects | Life Sciences | Africa/epidemiology | Asia, Southeastern/epidemiology | Plasmodium falciparum/isolation & purification | Artemisinins/pharmacology | Malaria, Falciparum/epidemiology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 7/2009, Volume 106, Issue 29, pp. 12025 - 12030
Journal Article
Nature (London), ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article