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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1419 - 1432
The small GTPase RAP1 is critical for platelet activation and thrombus formation. RAP1 activity in platelets is controlled by the GEF CalDAG-GEFI and an... 
GENE-MUTATIONS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN-KINASE-C | ADENOSINE-DIPHOSPHATE | ALPHA-IIB-BETA-3 ACTIVATION | MICE | CALDAG-GEFI | PLASMA-MEMBRANE | ADENYLATE-CYCLASE | ADP | MOUSE MODELS | Thrombopoiesis | Ticlopidine - pharmacology | rap1 GTP-Binding Proteins - antagonists & inhibitors | Platelet Activation - physiology | Thrombocytopenia - surgery | Splenectomy | Thrombocytopenia - genetics | Cellular Senescence | Hemostasis | Platelet Aggregation Inhibitors - pharmacology | GTPase-Activating Proteins - physiology | Guanine Nucleotide Exchange Factors - deficiency | Mice, Inbred C57BL | Receptors, Purinergic P2Y12 - physiology | Proto-Oncogene Proteins c-akt - physiology | Ticlopidine - analogs & derivatives | Mice, Knockout | Platelet Activation - genetics | Animals | rap1 GTP-Binding Proteins - physiology | Saphenous Vein - injuries | Clopidogrel | Mice | Mice, Inbred BALB C | Platelet Activation - drug effects | GTPase-Activating Proteins - genetics | Lymphopenia - genetics | Cell receptors | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Health aspects | Blood platelet disorders | Heart attacks | Laboratories | Cloning | Thrombosis | Embryos | Proteins | Studies | Blood platelets | Rodents | Technological change | Protein expression | Mutation | Infrared imaging systems | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 07/2013, Volume 63, Issue 3, pp. 280 - 288
Journal Article
BMB Reports, ISSN 1976-6696, 2014, Volume 47, Issue 12, pp. 655 - 659
Journal Article
Circulation, ISSN 0009-7322, 12/2007, Volume 116, Issue 25, pp. 2923 - 2932
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 05/2001, Volume 13, Issue 10, pp. 1913 - 1922
Journal Article
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7584, pp. 110 - 114
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). Mutant IDH protein produces a new... 
MAINTENANCE | METHYLATION | LANDSCAPE | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | ARCHITECTURE | PHENOTYPE | EXPRESSION | 2-HYDROXYGLUTARATE | PRINCIPLES | Chromatin - metabolism | Up-Regulation | Humans | Glioma - genetics | Base Sequence | Glioma - pathology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Chromatin - drug effects | Repressor Proteins - metabolism | Oncogenes - genetics | Insulator Elements - genetics | Glioma - enzymology | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Isocitrate Dehydrogenase - genetics | DNA Methylation - genetics | Down-Regulation - drug effects | Mutation - genetics | CRISPR-Cas Systems - genetics | Insulator Elements - drug effects | Phenotype | Isocitrate Dehydrogenase - chemistry | Receptor, Platelet-Derived Growth Factor alpha - genetics | CCCTC-Binding Factor | CpG Islands - genetics | Protein Binding | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Enhancer Elements, Genetic - genetics | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Chromatin - genetics | DNA Methylation - drug effects | Glioma - drug therapy | Complications and side effects | Care and treatment | Platelet-derived growth factor | Gliomas | Analysis | Influence | Genetic aspects | Research | Methylation | Oncogenes | DNA methylation | Epigenetics | Genomes | Mutation | Gene expression | Binding sites | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2012, Volume 167, Issue 1, pp. 109 - 127
BACKGROUND AND PURPOSE Ginsenosides are the main constituents for the pharmacological effects of Panax ginseng. Such effects of ginsenosides including... 
platelet | PI3K | thrombus | ginsenoside‐Rp1 | tyrosine‐phosphorylation | GPVI | ginsenoside-Rp1 | tyrosine-phosphorylation | PHOSPHOLIPASE C-GAMMA-2 | PHOSPHATIDYLINOSITOL 3-KINASE | PHOSPHOINOSITIDE 3-KINASE | VASODILATOR-STIMULATED PHOSPHOPROTEIN | PROTEIN-KINASES | RECEPTOR-GAMMA-CHAIN | ADHESION MECHANISMS | PHARMACOLOGY & PHARMACY | ANTIPLATELET THERAPIES | MOLECULAR-MECHANISMS | PREDOMINANT ROLE | Calcium - metabolism | P-Selectin - metabolism | Male | Ginsenosides - pharmacology | Phosphoproteins - metabolism | Adenosine Triphosphate - metabolism | Platelet Membrane Glycoproteins - metabolism | Platelet Aggregation Inhibitors - pharmacology | Collagen - pharmacology | Microfilament Proteins - metabolism | Platelet Aggregation - drug effects | Phosphorylation - drug effects | Thrombosis - prevention & control | Cyclic AMP - metabolism | Mice, Inbred C57BL | Rats | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Thromboxane A2 - metabolism | Tyrosine - metabolism | Animals | Blood Coagulation - drug effects | Cyclic GMP - metabolism | Mice | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Medical examination | Vasodilators | Thrombin | Thrombosis | Blood | Blood clot | Collagen | Genetically modified organisms | Phenols | Genetic research | Universities and colleges | Integrins | Index Medicus | Research Papers
Journal Article
Journal Article