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Journal Article
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2015, Volume 1851, Issue 4, pp. 422 - 432
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 28 - 33
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A₂... 
Enzymes | Prostaglandins | Active sites | Cyclooxygenase inhibitors | Atoms | Dimers | Platelet aggregation | Platelets | Fatty acids | Monomers | Platelet | Prostaglandin | Arachidonic acid | Adrenic acid | Nonsteroidal antiinflammatory drugs | arachidonic acid | SELECTIVE-INHIBITION | CONTACTS | adrenic acid | MECHANISM | prostaglandin | ENDOPEROXIDE-H SYNTHASE-1 | OXYGENATION | MULTIDISCIPLINARY SCIENCES | INDOMETHACIN | FATTY-ACIDS | CELECOXIB | RESPONSES | nonsteroidal antiinflammatory drugs | platelet | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aspirin - metabolism | Isoenzymes - metabolism | Cyclooxygenase 1 - chemistry | Platelet Aggregation Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Dogs | Aspirin - chemistry | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Cyclooxygenase 1 - metabolism | Aspirin | Usage | Physiological aspects | Cyclooxygenases | Genetic aspects | Research | Health aspects | CATALYSIS | MONOMERS | THROMBOSIS | ARACHIDONIC ACID | PROCESSING | DIMERS | 60 APPLIED LIFE SCIENCES | ACETYLSALICYLIC ACID | PROSTAGLANDINS | IN VITRO | INFLAMMATION | TARGETS | SIDE EFFECTS | Biological Sciences
Journal Article
Circulation Research, ISSN 0009-7330, 01/2013, Volume 112, Issue 1, pp. 174 - 194
The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has... 
ADVERSE CARDIOVASCULAR EVENTS | CARDIAC & CARDIOVASCULAR SYSTEMS | CONTROLLED-RELEASE ASPIRIN | prostaglandin | GENE SEQUENCE VARIATIONS | STIMULATED PHOSPHOPROTEIN PHOSPHORYLATION | PERCUTANEOUS CORONARY INTERVENTION | INDUCED PLATELET-AGGREGATION | LOW-DOSE ASPIRIN | ACUTE MYOCARDIAL-INFARCTION | aspirin | platelet | PERIPHERAL VASCULAR DISEASE | PROSTAGLANDIN ENDOPEROXIDE SYNTHASE | ST-SEGMENT ELEVATION | HEMATOLOGY | Purinergic P2Y Receptor Antagonists - administration & dosage | History, 21st Century | Ticlopidine - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Blood Platelets - enzymology | Dose-Response Relationship, Drug | Purinergic P2Y Receptor Antagonists - adverse effects | Cyclooxygenase Inhibitors - history | Platelet Aggregation Inhibitors - administration & dosage | Cardiovascular Diseases - blood | Aspirin - therapeutic use | Blood Platelets - drug effects | Platelet Aggregation Inhibitors - therapeutic use | Drug Resistance | Purinergic P2Y Receptor Antagonists - therapeutic use | Platelet Aggregation Inhibitors - adverse effects | Platelet Aggregation Inhibitors - history | Pharmacogenetics | Drug Discovery - history | History, 20th Century | Cyclooxygenase Inhibitors - administration & dosage | Evidence-Based Medicine | Ticlopidine - analogs & derivatives | Purinergic P2Y Receptor Antagonists - history | Translational Medical Research - history | Animals | Cardiovascular Diseases - history | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - therapeutic use | Platelet
Journal Article
Nature Communications, ISSN 2041-1723, 10/2013, Volume 4, Issue 1, pp. 2657 - 2657
Although it has long been known that patients with sepsis often have thrombocytopenia and that septic patients with severe thrombocytopenia have a poor... 
IMMUNE-RESPONSE | TUMOR-NECROSIS-FACTOR | NEUTROPHIL EXTRACELLULAR TRAPS | TOLL-LIKE RECEPTOR-4 | MULTIDISCIPLINARY SCIENCES | AUTOLOGOUS PLATELETS | LIPOPOLYSACCHARIDE | SEPSIS | NF-KAPPA-B | CRITICALLY-ILL PATIENTS | FACTOR-ALPHA | Inflammation - chemically induced | Inflammation - pathology | Blood Platelets - immunology | Receptors, Prostaglandin E, EP4 Subtype - immunology | Antibodies, Anti-Idiotypic - pharmacology | Humans | Macrophages, Peritoneal - pathology | Male | Dinoprostone - immunology | Shock, Septic - therapy | Thrombocytopenia - genetics | Blood Platelets - cytology | Tumor Necrosis Factor-alpha - immunology | Macrophages, Peritoneal - drug effects | Cyclooxygenase 1 - immunology | Disease Models, Animal | Shock, Septic - genetics | Receptors, Prostaglandin E, EP4 Subtype - genetics | Shock, Septic - pathology | Cyclooxygenase 1 - genetics | Shock, Septic - chemically induced | Signal Transduction | Dinoprostone - genetics | Membrane Proteins - genetics | Platelet Transfusion | Mice, Inbred C57BL | Gene Expression Regulation | Macrophages, Peritoneal - immunology | Membrane Proteins - immunology | Thrombocytopenia - chemically induced | Thrombocytopenia - pathology | Animals | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Inflammation - genetics | Interleukin-6 - biosynthesis | Thrombocytopenia - prevention & control | Inflammation - prevention & control | Mice | Tumor Necrosis Factor-alpha - biosynthesis | Platelet Glycoprotein GPIb-IX Complex - immunology
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2001, Volume 345, Issue 25, pp. 1809 - 1817
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 02/2019, Volume 352, Issue 2, pp. 1800265 - n/a
A new class of pyrazino[1,2‐a]benzimidazole derivatives possessing the SO2Me pharmacophore at the para position of the C‐3 phenyl ring was designed,... 
COX‐2 inhibitory | pyrazinobenzimidazole | docking study | anti‐cancer | anti‐platelet aggregation | MCF‐7 | anti-platelet aggregation | anti-cancer | MCF-7 | COX-2 inhibitory | CHEMISTRY, MEDICINAL | ISOFORMS | ANTICANCER | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY | Prevention | COX-2 inhibitors | Analysis | Cancer
Journal Article