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EMBO JOURNAL, ISSN 0261-4189, 07/2012, Volume 31, Issue 14, pp. 3118 - 3129
The molecular mechanisms by which receptors regulate the Ras Binding Domains of the PIP3-generating, class I PI3Ks remain poorly understood, despite their... 
GAMMA | REGULATORY SUBUNIT | NADPH OXIDASE | Ras | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | RasGRP4 | neutrophil | CELL DEVELOPMENT | CELL BIOLOGY | SIGNAL-TRANSDUCTION | PI3K | PLC beta | PATHWAY | NUCLEOTIDE-RELEASING PROTEIN | BINDING | PHOSPHOINOSITIDE 3-KINASE-GAMMA
Journal Article
Journal Article
MOLECULAR & CELLULAR PROTEOMICS, ISSN 1535-9476, 08/2013, Volume 12, Issue 8, pp. 2220 - 2235
Two isoforms of inositide-dependent phospholipase C 1 (PI-PLC1) are generated by alternative splicing (PLC1a and PLC1b). Both isoforms are present within the... 
ACTIVATION | COMPLEX | PLC-BETA | BIOCHEMICAL RESEARCH METHODS | INTERACTION NETWORKS | MUTATIONS | DIFFERENTIATION | LEUKEMIA | EXPRESSION | ASSOCIATION | STATISTICAL-MODEL
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 10/2019, Volume 62
Phospholipase C beta (PLC beta) enzymes regulate second messenger production following the activation of G protein coupled receptors (GPCRs). Under basal... 
GAMMA | Phosphatidylinositol lipids | DOMAIN | ACTIVATION | Calcium | PLC | Phospholipase C | CELL BIOLOGY | Signal transduction | Signaling proteins | C-BETA | Regulation | Electrostatics
Journal Article
ONCOTARGET, ISSN 1949-2553, 12/2016, Volume 7, Issue 51, pp. 84118 - 84127
In previous studies, we have reported that phospholipase C (PLC)-beta 1 plays a crucial role in myogenic differentiation and we determined the importance of... 
beta-catenin | COACTIVATOR | INOSITOL POLYPHOSPHATE MULTIKINASE | PENTAKISPHOSPHATE | IPMK | PHOSPHOLIPASE-C | INDUCTION | SKELETAL-MUSCLE DIFFERENTIATION | CELL BIOLOGY | ONCOLOGY | phospholipase C-beta 1 | WNT PATHWAY | myogenic differentiation | GENE-EXPRESSION | NUCLEAR PLC-BETA | inositol phosphates | PROMOTER
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2016, Volume 291, Issue 22, pp. 11608 - 11618
Journal Article
Journal Article
CELL COMMUNICATION AND SIGNALING, ISSN 1478-811X, 04/2013, Volume 11
Background: Protein kinase D (PKD) constitutes a novel family of serine/threonine protein kinases implicated in fundamental biological activities including... 
ALPHA-SUBUNITS | STIMULATION | HETEROTRIMERIC G-PROTEINS | PHOSPHORYLATION | G beta gamma dimers | PKD | RECEPTOR | GTP-BINDING PROTEINS | CELL BIOLOGY | PLC beta | REGULATES CELL-MIGRATION | PLECKSTRIN HOMOLOGY DOMAIN | GENE-EXPRESSION | G proteins | G alpha subunits
Journal Article
by Zhou, Q and Qin, SY and Zhang, JY and Zhon, L and Pen, ZH and Xing, TH
MOLECULAR IMMUNOLOGY, ISSN 0161-5890, 11/2017, Volume 91, pp. 156 - 164
Vitamin D has been recommended as an immune modulator in recent years, in addition to regulating calcium-phosphorous-bone metabolism. Clinical studies on organ... 
VITAMIN-D | ACTIVATION | TGF-BETA | Treg/Th17 cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNOLOGY | FOXP3 | TRANSPLANTATION | 1,25(OH)D-3 | VDR /PLC-gamma 1/TGF-beta 1 pathway | REJECTION | IMMUNE FUNCTION | ANTIGEN RECEPTOR | TH17 | EXPRESSION
Journal Article
STEM CELL REVIEWS AND REPORTS, ISSN 1550-8943, 12/2016, Volume 12, Issue 6, pp. 613 - 620
Migration and bone marrow (BM) homing of hematopoietic stem progenitor cells (HSPCs) is regulated by several signaling pathways, and here we provide evidence... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | C1P | MOBILIZATION | BONE-MARROW | SDF-1 | NICHE | PHOSPHOLIPASE-C-BETA | RECEPTOR | HO-1 | MEMBRANE-LIPID RAFTS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | SIGNAL-TRANSDUCTION | MIGRATING CELLS | PLC-beta 2; Stem cell homing | S1P
Journal Article
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, ISSN 1461-1457, 03/2019, Volume 22, Issue 3, pp. 221 - 231
Background: Schizophrenia is a complex neuropsychiatric disorder characterized by psychoses, socioaffective disturbances, and cognitive deficits. The... 
GAMMA | CLOZAPINE | PROTEIN-KINASE-C | PLC-B1 KO mice | PSYCHIATRY | EEG | neural oscillations | NEUROSCIENCES | CLINICAL NEUROLOGY | electrophysiology | MEMORY | PHARMACOKINETICS | CORTEX | PHARMACOLOGY & PHARMACY | antipsychotic | OLANZAPINE | animal model | RECEPTORS | DEFICITS
Journal Article
Journal Article
by Liu, WJ and Lu, YJ and Chu, SM and Jiang, M and Bai, G
JOURNAL OF FUNCTIONAL FOODS, ISSN 1756-4646, 09/2019, Volume 60
Intracellular Ca2+ concentration ([Ca2+](i)) disorder is one of the important pathogeneses of hypertension. Phillygenin (Phi) is a lignan compound found in... 
PHOSPHOLIPASE-C ACTIVITY | PLC beta 3 | FOOD SCIENCE & TECHNOLOGY | Calcium antagonist | PHILLYRIN | SUSPENSA THUNB. VAHL | Vasorelaxant | BLOOD-PRESSURE | BETA | Antihypertensive | RESPONSES | NUTRITION & DIETETICS | Phillygenin | EXPRESSION
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 08/2007, Volume 406, pp. 157 - 165
The requirement of DAG (diacylglycerol) to recruit PKD (protein kinase D) to the TGN (trans-Golgi network) for the targeting of transport carriers to the cell... 
TRANSLOCATION | ACTIVATION | COMPLEX | HETEROTRIMERIC G-PROTEINS | ALPHA-SUBUNIT | PROTEIN-KINASE-D | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | IDENTIFICATION | protein kinase D (PKD) | ORGANIZATION | SMOOTH-MUSCLE | phospholipase C (PLC) | Golgi | trafficking | diacylglycerol (DAG) | GTP-binding protein beta gamma subunits (G beta gamma)
Journal Article
MOLECULAR CARCINOGENESIS, ISSN 0899-1987, 12/2016, Volume 55, Issue 12, pp. 2210 - 2221
Limited oxygen availability plays a critical role in the malignant progression of breast cancer by orchestrating a complex modulation of the gene transcription... 
MIGRATION | PATHWAYS | hypoxia | PLC-beta 2 | METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | breast cancer | MESENCHYMAL TRANSITION | EMT | CANCER STEM-CELLS | INDUCIBLE FACTORS | FACTOR-1 | ONCOLOGY | ESTROGEN | PROMOTES | EXPRESSION | CD133
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 04/2014, Volume 446, Issue 2, pp. 638 - 643
The formation of CXCR2-NHERF1-PLC beta 3 macromolecular complex in pancreatic cancer cells regulates CXCR2 signaling activity and plays an important role in... 
X-ray crystallography | NHERF1 | BIOPHYSICS | PDZ DOMAINS | PLC beta 3 | Pancreatic cancer | BIOCHEMISTRY & MOLECULAR BIOLOGY | CXCR2 | AUTOCRINE GROWTH | RECEPTOR | MACROMOLECULAR COMPLEX | Scaffold protein
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 10/2009, Volume 392, Issue 4, pp. 1044 - 1054
G beta subunits from heterotrimeric G-proteins (guanine nucleotide-binding proteins) directly bind diverse proteins, including effectors and regulators, to... 
PHYLOGENY | COMPLEX | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GAMMA-SUBUNITS | INFERENCE | PLC-beta 2-G-beta gamma interaction interface | PHOSDUCIN | REGULATOR | phospholipase C-beta 2 | ELEGANS | interface prediction | DIVERGENCE | protein surface evolution | heterotrimeric G-proteins
Journal Article
ACTA HISTOCHEMICA, ISSN 0065-1281, 2019, Volume 121, Issue 4, pp. 484 - 490
Phospholipase C (PLC)beta has a role in saliva secretion by controlling intracellular Ca2+ via its product, IP3. The present study was attempted to localize... 
CELLS | TRANSLOCATION | COMPLEX | ISOFORMS | ACETYLCHOLINE | PLC beta 3 | PAROTID-GLAND | CA2+ RELEASE | Salivary gland | IDENTIFICATION | PLASMA-MEMBRANE | CELL BIOLOGY | PURIFICATION | Mice | Localization
Journal Article
by Yin, Z and Xu, HJ and Yao, XL and Liu, G and Nie, CJ and Wei, H and Li, C and Liang, ML and Ming, ZY and Zhang, XJ
ENVIRONMENTAL TOXICOLOGY, ISSN 1520-4081, 02/2017, Volume 32, Issue 2, pp. 530 - 540
AimsIt has been proven that carbon nanoparticles or diesel exhaust particles stimulate platelet activation. However, the effect of fine particle matter (PM2.5)... 
INTEGRIN ALPHABETA | COARSE | PROTEIN-KINASE | WATER RESOURCES | INDUCTION | platelet activation | PLC gamma 2 | ENVIRONMENTAL SCIENCES | PM2.5 | ULTRAFINE PARTICLES | PARTICULATE AIR-POLLUTION | TOXICOLOGY | SECRETION | HEALTH | CYTOTOXICITY | Akt/GSK3 beta | AGGREGATION
Journal Article
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