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plcβ (26) 26
animals (16) 16
index medicus (13) 13
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humans (11) 11
plc beta (11) 11
signal transduction (10) 10
biochemistry & molecular biology (9) 9
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plc-β (7) 7
phospholipase c beta - metabolism (6) 6
phosphorylation (6) 6
activation (5) 5
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g protein (5) 5
phospholipase c beta (5) 5
pi turnover (5) 5
signal transduction - drug effects (5) 5
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ras (4) 4
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receptor (3) 3
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type c phospholipases - metabolism (3) 3
vsmc (3) 3
2-apb, 2-aminoethoxyphenylborane (2) 2
[ca2+]i, intracellular free ca2+ concentration (2) 2
ac, adenylyl cyclase (2) 2
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airway smooth muscle (2) 2
akt (2) 2
angiotensin-ii (2) 2
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camp, 3',5'-cyclic amp (2) 2
cardiovascular system (2) 2
carrier proteins - metabolism (2) 2
cell membrane - metabolism (2) 2
cells, cultured (2) 2
chondrocytes (2) 2
copd, chronic obstructive pulmonary disease (2) 2
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cyclic amp (2) 2
desensitization (2) 2
diacylglycerol (2) 2
dmso, dimethyl sulfoxide (2) 2
ec50, half-maximally effective (2) 2
endocrinology & metabolism (2) 2
epac, exchange protein activated by camp (2) 2
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ha, haemagglutinin (2) 2
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hbs, hepes-buffered saline (2) 2
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hela cells (2) 2
heterotrimeric g proteins (2) 2
heterotrimeric g-proteins (2) 2
heterotrimeric gtp-binding proteins - metabolism (2) 2
ibmx, 3-isobutyl-1-methylxanthine (2) 2
identification (2) 2
in-vitro (2) 2
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Advances in Biological Regulation, ISSN 2212-4926, 09/2013, Volume 53, Issue 3, pp. 249 - 257
Journal Article
Neuromethods, ISSN 0893-2336, 2015, Volume 96, pp. 251 - 263
Journal Article
Cell Communication and Signaling, ISSN 1478-811X, 2013, Volume 11, Issue 1, pp. 22 - 22
Protein kinase D (PKD) constitutes a novel family of serine/threonine protein kinases implicated in fundamental biological activities including cell... 
Gα subunits | PKD | G proteins | Gβγ dimers | PLCβ
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 06/1998, Volume 10, Issue 6, pp. 2016 - 2025
Ligand binding to neurotransmitter and hormone receptors which couple to the Gq subclass of GTP‐binding protein leads to the activation of phospholipase Cβ... 
development | GTP‐binding protein | PLCβ | in situ hybridization | Development | GTP-binding protein | In situ hybridization | ALPHA-SUBUNITS | METABOTROPIC GLUTAMATE RECEPTOR | NEUROSCIENCES | PROTEIN KINASE-C | MESSENGER-RNAS | PLC beta | GENE | SEQUENCE | MOLECULAR-CLONING | RAT-BRAIN | INSITU HYBRIDIZATION | SIGNAL TRANSDUCTION
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2014, Volume 588, Issue 24, pp. 4604 - 4612
Phospholipase A (PLA ) is an important component in snake venoms. Here, an acidic PLA , designated PA2-Vb was isolated from the snake venom. PA2-Vb acts on a... 
Vasoconstrictor activity | Acidic phospholipase A2 | Ca2+ release | IP3 receptor | Crystal structure | IP3R | phospholipase Cβ | RyR | sarcoplasmic reticulum | 2-APB | svPLA2 | reversible permeabilization | GPCRs | ryanodine receptor | vascular smooth muscle cells | VSMCs | PAR-1 | protease-activated receptor 1 | 2-aminoethoxy diphenyl borate | G-protein coupled receptors | PLA2 | p-bromofenacil bromide | PLCβ | snake venom PLA2 | phospholipases A2 | pBPB | inositol 1,4,5-trisphosphate receptor | Acidic phospholipase A | receptor | release | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | X-RAY-DIFFRACTION | SARCOPLASMIC-RETICULUM | RELEASE | CELL BIOLOGY | NAJA-NAJA | SMOOTH-MUSCLE | INOSITOL 1,4,5-TRISPHOSPHATE | BIOPHYSICS | CHANNELS | VASOCONSTRICTION | Amino Acid Sequence | Calcium - metabolism | Protein Multimerization | Models, Molecular | Molecular Sequence Data | Phospholipases A2 - pharmacology | Crystallography, X-Ray | Crotalid Venoms - enzymology | Muscle, Smooth, Vascular - cytology | Vasoconstriction - drug effects | Animals | Receptors, Proteinase-Activated - agonists | Protein Structure, Quaternary | Phospholipases A2 - isolation & purification | Muscle, Smooth, Vascular - physiology | Trimeresurus | Hydrogen-Ion Concentration | Muscle, Smooth, Vascular - drug effects | Phospholipases A2 - chemistry | Inositol | Phospholipases | Structure | Proteases | Venom | Crystals | Snakes | Borates
Journal Article
Journal Article
Biochemistry and Cell Biology, ISSN 0829-8211, 12/1999, Volume 77, Issue 6, pp. 569 - 575
Although fibroblast growth factor-2 (FGF-2) plays an important role in cardioprotection and growth, little is known about the signals triggered by it in the... 
PLC γ | FGF-2 | Signal transduction | Cardiomyocytes | PLC β
Journal Article
Peptides, ISSN 0196-9781, 12/2018, Volume 110, pp. 47 - 55
Our previous work demonstrated that the C-type natriuretic peptide (CNP)/cyclic guanosine monophosphate (cGMP)/cyclic adenosine monophosphate (cAMP) pathway in... 
PKG /PKA -PLCβ | Trisphosphate inositol | C-type natriuretic peptide | β-type phospholipase C | Diabetic gastric dysmotility | NATRIURETIC-PEPTIDE | SMOOTH-MUSCLE | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | beta-type phospholipase C | PKG /PKA -PLC beta | PKA | ENDOCRINOLOGY & METABOLISM | PHARMACOLOGY & PHARMACY
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2001, Volume 175, Issue 1, pp. 149 - 156
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2003, Volume 88, Issue 6, pp. 1101 - 1111
Heterotrimeric G proteins mediate cell growth and differentiation by coupling cell surface receptors to intracellular effector enzymes. The G‐protein α... 
GPCR | protein phosphorylation | heterotrimeric G proteins | Gα15/16 | phospholipase C‐β (PLC‐β) | Phospholipase C-β (PLC-β) | Protein phosphorylation | Heterotrimeric G proteins
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2002, Volume 22, Issue 6, pp. 2274 - 2282
Second messenger systems mediate neuronal responses to extracellular factors that elicit axon branching, turning, and guidance. We found that mutations in... 
Phospholipase Cβ | UNC-6 | Netrin | Gqα | G-protein subunit | Neuropeptide Y receptor | Diacylglycerol kinase | PLCβ | Calcium/calmodulin-dependent protein kinase | DAK | Guidance | Caenorhabditis elegans | CaMKII | Axon branching | Genetics | RECEPTOR | axon branching | genetics | PLC beta | neuropeptide Y receptor | G(Q)ALPHA | phospholipase beta | calcium/calmodulin-dependent protein kinase | MUTATIONS | MIGRATIONS | netrin | GROWTH CONE GUIDANCE | diacylglycerol kinase | NERVE GROWTH | NEUROSCIENCES | Gq alpha | guidance | IN-VIVO | TISSUE INHIBITOR | SYNAPTIC TRANSMISSION | BINDING | Protein Subunits | Helminth Proteins - pharmacology | Receptors, Neuropeptide Y - metabolism | Type C Phospholipases - metabolism | Heterotrimeric GTP-Binding Proteins - metabolism | Axons - physiology | Nerve Growth Factors - metabolism | Phospholipase C beta | Diglycerides - pharmacology | Isoenzymes - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 | Helminth Proteins - metabolism | Motor Neurons - drug effects | Caenorhabditis elegans Proteins | Animals, Genetically Modified | Diacylglycerol Kinase - metabolism | Axons - drug effects | Helminth Proteins - genetics | Nerve Tissue Proteins | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Netrins | Motor Neurons - metabolism | Animals | Receptors, Neuropeptide Y - genetics | Signal Transduction - drug effects | GTP-Binding Protein alpha Subunits, Gq-G11 | Alleles | Second Messenger Systems - physiology | Signal Transduction - physiology | Mutation | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Protein Structure, Tertiary - physiology
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2005, Volume 386, Issue 1, pp. 177 - 189
Like Ras, farnesylation of the IP (prostacyclin receptor) is required for its efficient intracellular signalling, and hence the IP represents a potential... 
Thromboxane A | Desensitization | Farnesyl protein transferase inhibitor | Prostacyclin receptor | Ras | Isoprenylation | CELLS | ANGIOGENESIS | N-RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | prostacyclin receptor | desensitization | CANCER-THERAPY | FARNESYLTRANSFERASE INHIBITORS | IN-VITRO | HA-RAS | PRENYLATION | GROWTH | thromboxane A | isoprenylation | farnesyl protein transferase inhibitor | Propanolamines - metabolism | Proline - metabolism | Humans | Alkyl and Aryl Transferases - antagonists & inhibitors | HSP40 Heat-Shock Proteins | Iloprost - metabolism | Receptors, Adrenergic, beta-2 - drug effects | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Kidney | Dose-Response Relationship, Drug | Transfection | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Proto-Oncogene Proteins p21(ras) - chemistry | Receptors, Thromboxane A2, Prostaglandin H2 - drug effects | Epoprostenol - pharmacology | Cell Line, Tumor - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Cell Line | Protein Prenylation - drug effects | Receptors, Epoprostenol - metabolism | Mutagenesis, Site-Directed | Proline - analogs & derivatives | Receptors, Adrenergic, beta-2 - genetics | Endocytosis - drug effects | Heat-Shock Proteins - metabolism | Adrenergic beta-Agonists - pharmacology | Farnesyltranstransferase | Amino Acid Motifs | Epoprostenol - analogs & derivatives | Animals | Carrier Proteins - metabolism | Cyclic AMP - biosynthesis | Signal Transduction - drug effects | Calcium Signaling - drug effects | Leukemia, Erythroblastic, Acute - pathology | Isoproterenol - pharmacology | Mice | Pyridines - pharmacology | Receptors, Epoprostenol - drug effects | HEL, human erythroleukaemia | N-Ras, neuronal Ras | Ki-Ras, Kirsten Ras | HEK, human embryonic kidney | β2AR, β2 adrenergic receptor | GGPP, geranylgeranyl pyrophosphate | thromboxane A2 | GPCR, G-protein-coupled receptor | FPP, farnesyl pyrophosphate | PLCβ, phospholipase Cβ | Ha-Ras, Harvey Ras | MVA, mevalonolactone | GGTase, geranylgeranyl protein transferase | fura 2 | AM, fura 2 acetoxymethyl ester | FBS, fetal bovine serum | FTI, farnesyl protein transferase inhibitor | LDH, lactate dehydrogenase | PKA, cAMP-dependent protein kinase | [Ca2+]i, intracellular calcium | FTase, farnesyl protein transferase | HA, haemagglutinin | mouse) prostacyclin receptor | m)IP, (human | TXA2, thromboxane A2 | TP, prostanoid TXA2 receptor
Journal Article
Neuroscience, ISSN 0306-4522, 2005, Volume 133, Issue 2, pp. 393 - 403
Conventional protein kinase C (cPKC) isoforms are activated by a coincident rise in cytosolic Ca and membrane-bound diacylglycerol. In excitable cells, cPKC... 
conventional protein kinase C | YFP | voltage-gated Ca 2+ channels | PKCα tagged with yellow fluorescent protein | intracellular Ca 2+ concentration | pheochromocytoma cells | [Ca 2+] i | PKC | cPKC | DAG | phospholipase C-β | PC12 cells | PLCβ | PC12 | fura-2 | depolarization | yellow fluorescent protein | VGCC | diacylglycerol | protein kinase C | PKCα-YFP
Journal Article