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FEBS Letters, ISSN 0014-5793, 02/2012, Volume 586, Issue 3, pp. 263 - 269
► We investigate the role of VapB in RANKL-induced osteoclast differentiation. ► Knock-down of VapB suppressed osteoclastogenesis. ► Over-expression of VapB... 
Osteoclast | NFATc1 | VapB | PLCγ2
Journal Article
Bone, ISSN 8756-3282, 03/2014, Volume 60, pp. 104 - 111
Owing to their potential pharmacological activities in human disease, natural plant-derived compounds have recently become the focus of increased research... 
Calcium oscillation | Osteoclast | NFATc1 | PLCγ2 | Oleanolic acid acetate
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 06/2019, Volume 100, pp. 62 - 74
Cytokine storm syndrome (CSS) is a life-threatening condition characterized by excessive activation of T cells and uncontrolled inflammation, mostly described... 
Inflammation | Cytokine storm syndrome | Monocyte | Plcγ2 | Tmem178 | Macrophage
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 06/2010, Volume 8, Issue 6, pp. 1353 - 1363
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 01/2008, Volume 51, Issue 1, pp. 45 - 54
We have previously reported that green tea catechins displayed a potent antithrombotic effect by inhibition of platelet aggregation. In the present study, the... 
Epigallocatechin gallate | Atherothrombosis | PLCγ2 | Antiplatelet activity
Journal Article
Development, ISSN 0950-1991, 01/2009, Volume 136, Issue 2, pp. 191 - 195
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 12/2003, Volume 198, Issue 12, pp. 1841 - 1851
Two important Ras guanine nucleotide exchange factors, Son of sevenless (Sos) and Ras guanine nucleotide releasing protein (RasGRP), have been implicated in... 
RasGRP3 | DAG | B cell activation | PLC-γ2 | ERK
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2008, Volume 50, Issue 5, pp. 147 - 152
Abstract Beta-carboline alkaloids including harmalol, harmaline, norharmane, harmol, harmine and harmane are important constituents of the medicinal plant,... 
Cardiovascular | β-carboline alkaloids | PLCγ2 | Collagen | Antiplatelet activity
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 9/2012, Volume 189, Issue 5, pp. 2326 - 2332
One of the important signaling events following T-cell receptor (TCR) engagement is activation of phospholipase Cγ (PLCγ). PLCγ has two isoforms, PLCγ1 and... 
TCR | T cells | signal transduction | PLCγ2
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2007, Volume 100, Issue 5, pp. 1255 - 1265
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 03/2003, Volume 160, Issue 5, pp. 769 - 780
Collagen plays a critical role in hemostasis by promoting adhesion and activation of platelets at sites of vessel injury. In the present model of... 
FAK | Blood platelets | PLCγ2 | Inregrin α | Cell spreading | integrin α2β1; blood platelets; cell spreading; PLCγ2; FAK
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 03/2010, Volume 1192, Issue 1, pp. 124 - 130
Identifying common signaling pathways to bone and immune system may lead to better therapeutic approaches in diseases such as inflammatory arthritis. In this... 
arthritis | inflammation | osteoclasts | bone | PLCγ2 | neutrophils
Journal Article
Platelets, ISSN 0953-7104, 08/2010, Volume 21, Issue 3, pp. 211 - 220
Turmeric (Curcuma longa), a herbal remedy and culinary spice, has been used in traditional Indian culture for millennia. An active ingredient found in turmeric... 
Curcumin | Syk | PLCγ2 | GPVI | platelet activation | Platelet activation | PLC2
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, pp. 2863 - 2863
Background: The auto-inflammation and phospholipase C gamma 2 (PLC gamma 2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare... 
cutis laxa | auto-inflammatory syndromes | APLAID | IL-1b | PLCγ2 | sensorineural deafness | IL-10 | AUTOIMMUNITY | DISEASE | IMMUNOLOGY | PHOSPHOLIPASE C-GAMMA | PLC gamma 2 | Immunologic diseases | Genetic aspects | Cutis laxa | Research | Gene mutations
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2003, Volume 22, Issue 18, pp. 4677 - 4688
In non‐excitable cells, receptor‐activated Ca 2+ signalling comprises initial transient responses followed by a Ca 2+ entry‐dependent sustained and/or... 
2 | influx | signal amplification | TRPC | C2 domain | PLCγ2 | Ca | Signal amplification | Ca2+ influx
Journal Article
Platelets, ISSN 0953-7104, 01/2010, Volume 21, Issue 3, pp. 211 - 220
Turmeric (Curcuma longa), a herbal remedy and culinary spice, has been used in traditional Indian culture for millennia. An active ingredient found in turmeric... 
Curcumin | Syk | PLCγ2 | GPVI | platelet activation
Journal Article
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