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JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2000, Volume 275, Issue 30, pp. 23355 - 23361
The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated signaling and thymocyte... 
ZAP-70 | ACTIVATION | DOMAIN | SLP-76 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOLECULAR-CLONING | PLC-GAMMA-1 | EXCHANGE | ADAPTER PROTEIN | KINASES | REQUIREMENT
Journal Article
by Tang, WQ and Zhou, Y and Sun, DL and Dong, L and Xia, JL and Yang, BW
HEPATOLOGY RESEARCH, ISSN 1386-6346, 05/2019, Volume 49, Issue 5, pp. 559 - 569
Aim Phospholipase C-gamma 1 (PLCG1) was previously found to be involved in a variety of oncogenic behaviors such as cell motility, cell proliferation, cell... 
GAMMA | MIGRATION | PLCG1 MUTATIONS | TYROSINE KINASE | PROLIFERATION | PLC-GAMMA-1 | prognosis | CANCER | INVASION | tumor growth | PLCG1 | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | hepatocellular carcinoma
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 02/2014, Volume 1838, Issue 2, pp. 557 - 568
During T cell activation, the engagement of a T cell with an antigen-presenting cell (APC) results in rapid cytoskeletal rearrangements and a dramatic increase... 
Signaling | Cytoskeleton | TCR | Actin polymerization | Calcium | Lymphocyte | OPERATED CA2+ CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRAC CHANNELS | PHOSPHOLIPASE C-GAMMA-1 PLC-GAMMA-1 | SIGNAL-TRANSDUCTION | BIOPHYSICS | STROMAL INTERACTION MOLECULE-1 | ANTIGEN-RECEPTOR | ENDOPLASMIC-RETICULUM | IMMUNOLOGICAL SYNAPSE | ADAPTER PROTEIN | T cells
Journal Article
INTERNATIONAL JOURNAL OF CANCER, ISSN 0020-7136, 03/2013, Volume 132, Issue 5, pp. 1022 - 1031
Phospholipase C gamma 1 (PLC gamma 1) is highly expressed in several tumors. We have previously reported that both stable and inducible PLC gamma 1... 
INTERNATIONAL EXPERT CONSENSUS | phospholipase C gamma 1 | PRIMARY THERAPY | TYROSINE PHOSPHORYLATION | TUMOR PROGRESSION | CYTOSKELETON | MECHANISM | breast cancer | HIGHLIGHTS | PLC-GAMMA-1 | prognosis | chemotherapy | ONCOLOGY | metastasis | CELL-MIGRATION | SUBSTRATE
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 12/2010, Volume 285, Issue 50, pp. 38781 - 38787
CCR7 binds to its cognate ligand, CCL21, to mediate the migration of circulating naive T lymphocytes to the lymph nodes. T lymphocytes can bind to fibronectin,... 
PATHWAYS | ADHESION | ACTIVATION | CHEMOTAXIS | INTEGRIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYMPH-NODE | SMOOTH-MUSCLE-CELLS | RECEPTORS | PLC-GAMMA-1 | PROMOTES
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2013, Volume 31, Issue 7, pp. 1252 - 1265
Stem cell-like properties of glioma initiating cells (GiCs) fuel glioblastoma (GBM) development by providing the different cell types that comprise the tumor.... 
Glioblastoma | NOTCH | Extracellular signal-regulated kinase | SELF-RENEWAL | Delta like 3 protein | IDENTIFICATION | PLC-GAMMA-1 | TUMORS | miR-18a | CANCER STEM-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Sonic hedgehog | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | HEMATOLOGY | EXPRESSION | HIERARCHY | REVEALS
Journal Article
by Zeng, GQ and Cui, X and Liu, ZJ and Zhao, HH and Zheng, XP and Zhang, B and Xia, C
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 08/2014, Volume 15, Issue 8, pp. 13236 - 13246
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation including extracellular matrix (ECM) degradation and cell... 
APOPTOSIS | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLC-gamma 1 | PLC-GAMMA-1 | CHEMISTRY, MULTIDISCIPLINARY | ECM | MTOR | PLC-GAMMA | human OA chondrocytes | ARTICULAR-CARTILAGE | PATHWAY | EXPRESSION
Journal Article
by Chen, X and Li, XM and Gu, W and Wang, D and Chen, Y and Guo, XJ
INTERNATIONAL IMMUNOPHARMACOLOGY, ISSN 1567-5769, 03/2017, Volume 44, pp. 9 - 15
Introduction: Low expression of linker for activation of T cells (LAT) is observed in asthma. LAT and its downstream regulator, phospholipase Cgamma 1... 
PHOSPHOLIPASE C-GAMMA-1 | ACTIVATION | TOLERANCE | AIRWAY INFLAMMATION | RECEPTOR | IMMUNOLOGY | PLC-gamma 1 | Th2 cells | PLC-GAMMA-1 | Asthma | TYROSINE RESIDUES | IN-VIVO | ADAPTER | REGULATORY T-CELLS | Treg cells | PHARMACOLOGY & PHARMACY | LAT
Journal Article
JOURNAL OF PROTEOME RESEARCH, ISSN 1535-3893, 08/2017, Volume 16, Issue 8, pp. 2729 - 2742
Phospholipase C gamma 1 (PLC-gamma 1) occupies a critically important position in the T-cell signaling pathway. While its functions as a regulator of both Ca2+... 
phosphoproteomics | SLP-76 | C-GAMMA-1 PLC-GAMMA-1 | BIOCHEMICAL RESEARCH METHODS | HOMOLOGY 2 DOMAIN | INDUCED TYROSINE PHOSPHORYLATION | PLC-gamma 1 | MASS-SPECTROMETRY | T-cell signaling | SIGNAL-TRANSDUCTION | LC-MS | Lck | PHOSPHOLIPASE-C-GAMMA | ANTIGEN RECEPTOR | ADAPTER PROTEIN | label-free quantitation | TEC FAMILY KINASES | SH3 DOMAIN
Journal Article
CELLULAR SIGNALLING, ISSN 0898-6568, 04/2014, Volume 26, Issue 4, pp. 797 - 805
Phospholipase C-gamma 1 (PLC-gamma 1) is a key regulator of T cell receptor (TCR)-induced signaling. Activation of the TCR enhances PLC-gamma 1 enzymatic... 
RECRUITMENT | TCR | SIGNALING PATHWAYS | FEEDBACK-CONTROL | PHOSPHORYLATION | RECEPTOR | PLC-gamma 1 | PHOSPHOLIPASE C-GAMMA-1 PLC-GAMMA-1 | CELL BIOLOGY | TYROSINE RESIDUES | Phosphorylation kinetics | Grb2 | T-CELL DEVELOPMENT | LAT | LINKER | ANTIGEN | Tyrosine | Activated | Cellular | Phosphorylation | Activation | Mathematical models | Position (location) | Signalling
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 04/2007, Volume 104, Issue 16, pp. 6638 - 6643
ITK (IL-2-inducible T cell kinase), a Tec family protein tyrosine kinase (PTK), is one of three PTKs required for T cell antigen receptor (TCR)-induced... 
DOMAIN | signal transduction | PHOSPHORYLATION | C-GAMMA-1 | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | kinase regulation | PLC-GAMMA-1 | ZAP-70 | adaptor protein | phospholipase C-gamma | BINDING-SITE | PHOSPHOLIPASE-C-GAMMA | RECONSTITUTION | REQUIREMENT
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2002, Volume 158, Issue 7, pp. 1263 - 1275
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 02/2006, Volume 25, Issue 4, pp. 774 - 784
Engagement of the T- cell antigen receptor leads to recruitment of phospholipase C gamma 1 ( PLC gamma 1) to the LAT- nucleated signaling complex and to PLC... 
TCR | EXCHANGE FACTOR | calcium | ADAPTER PROTEINS | TYROSINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE C-GAMMA-1 PLC-GAMMA-1 | CELL BIOLOGY | SIGNAL-TRANSDUCTION | TEC KINASES | confocal microscopy | MEDIATED ACTIVATION | BINDING-SITE | FRET | protein-protein interaction | ACTIN CYTOSKELETON | ANTIGEN RECEPTOR
Journal Article