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CANCER DISCOVERY, ISSN 2159-8274, 11/2015, Volume 5, Issue 11, pp. 1194 - 1209
mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation... 
TARGET | PROTEIN | RAG GTPASES | ONCOLOGY | PHOSPHORYLATION | INTEGRITY | PLECKSTRIN HOMOLOGY DOMAIN | SIGNALS | AKT | BINDING | SIN1
Journal Article
by Lin, AF and Hu, QS and Li, CL and Xing, Z and Ma, GL and Wang, C and Li, J and Ye, Y and Yao, J and Liang, K and Wang, SY and Park, PK and Marks, JR and Zhou, Y and Zhou, JW and Hung, MC and Liang, H and Hu, ZB and Shen, HB and Hawke, DH and Han, L and Zhou, YB and Lin, CR and Yang, LQ
NATURE CELL BIOLOGY, ISSN 1465-7392, 03/2017, Volume 19, Issue 3, pp. 238 - 251
Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns(3,4,5)P-3 or PIP3) mediates signalling pathways as a second messenger in response to extracellular signals.... 
BREAST-CANCER | INOSITOL PHOSPHATES | IN-VITRO | PROTEIN-KINASE-B | LONG NONCODING RNA | SOLID TUMORS | SIGNALING PATHWAY | PLECKSTRIN HOMOLOGY DOMAIN | GLOBAL ANALYSIS | HIGH-AFFINITY BINDING | CELL BIOLOGY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 6, pp. 1075 - 1083
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 11/2015, Volume 14, Issue 11, pp. 2441 - 2451
AKT1(E17K) mutations occur at low frequency in a variety of solid tumors, including those of the breast and urinary bladder. Although this mutation has been... 
CELLS | ONCOGENIC MUTATION | PIK3CA | ONCOLOGY | PATHWAY | PLECKSTRIN HOMOLOGY DOMAIN | MODEL | E17K MUTATION | BREAST
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 585 - 594
The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid ceramide in a diverse range of...