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Pediatric Infectious Disease Journal, ISSN 0891-3668, 04/2003, Volume 22, Issue 4, pp. 335 - 340
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 04/2019, Volume 9, Issue 1, pp. 6023 - 9
We describe the development, optimisation, and validation of an automated, cell-based and high-throughput screening assay using existing luminescence-based ATP... 
IN-VITRO | PLECONARIL | COXSACKIEVIRUS | MOUTH-DISEASE | MULTIDISCIPLINARY SCIENCES | VALIDATION | INHIBITOR | OUTBREAK | HAND | FOOT | High-throughput screening | Automation | Luminescence | Cell density
Journal Article
RSC Advances, ISSN 2046-2069, 2015, Volume 5, Issue 68, pp. 55100 - 55108
A series of novel human enterovirus 71 inhibitors, N-benzyl-N-phenylthiophene-2-carboxamide analogues, were synthesized and their antiviral activities were... 
RHINOVIRUS INFECTIONS | DESIGN | PLECONARIL | POTENT | ENVIROXIME | POLIOVIRUS | ANTIPICORNAVIRUS ACTIVITY | ANTIVIRAL ACTIVITY | TYPE-1 | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
SCIENCE, ISSN 0036-8075, 01/2015, Volume 347, Issue 6217, pp. 71 - 74
Journal Article
Journal of Microbiology, Immunology and Infection, ISSN 1684-1182, 12/2019, Volume 52, Issue 6, pp. 851 - 857
Enteroviruses generally cause mild and self-limited diseases, but they have been found to affect neonates much differently, and often more severely than older... 
Myocarditis | Intravenous immunoglobulin | Neonates | Enterovirus | Coagulopathy | ANTIBODIES | DIAGNOSIS | INFECTIOUS DISEASES | PLECONARIL | PERINATAL ECHOVIRUS INFECTION | SEPSIS-LIKE ILLNESS | MICROBIOLOGY | IMMUNOLOGY | MENINGITIS | OUTBREAKS | EPIDEMIOLOGY
Journal Article
WIENER KLINISCHE WOCHENSCHRIFT, ISSN 0043-5325, 01/2018, Volume 130, Issue 1-2, pp. 70 - 72
Chronic enteroviral meningoencephalitis, most commonly caused by echoviruses, can particularly be seen in agammaglobulinemic patients. In spite of the fact... 
CVID | MEDICINE, GENERAL & INTERNAL | Echoviruses | IN-VITRO | CHRONIC ENTEROVIRAL MENINGOENCEPHALITIS | INFANTS | DISEASE | Enterovirus | Pleconaril | INFECTION | Meningoencephalitis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 178, pp. 606 - 622
The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino- and enteroviruses (RV and EV) using small molecules. The highly conserved... 
Common cold | Pleconaril | Enterovirus | Drug design/discovery | Antivirals | Rhinovirus | CHEMISTRY, MEDICINAL | ANTI-VIRAL ACTIVITY | INVITRO ACTIVITY | ANTIRHINOVIRAL ACTIVITY | COXSACKIEVIRUS B3 | BETA-DIKETONES | CYTOCHROME-P450 3A ACTIVITY | ANTIVIRAL ACTIVITY | ANTIPICORNAVIRUS ACTIVITY | PYRIDYL IMIDAZOLIDINONES | IN-VITRO ACTIVITY | Viral proteins | Amino acids | Drug approval
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2012, Volume 8, Issue 10, p. e1002976
Viruses use a limited set of host pathways for infection. These pathways represent bona fide antiviral targets with low likelihood of viral resistance. We... 
RAT-LIVER | LOW-PH | CELLS | PLECONARIL | VIRUS | ENTRY | HUMAN RHINOVIRUSES | MICROBIOLOGY | NITAZOXANIDE | RESPIRATORY SYNDROME CORONAVIRUS | REPLICATION | VIROLOGY | PARASITOLOGY | Influenza viruses | Physiological aspects | Antiviral agents | Amides | Rhinoviruses | Health aspects | Proteins | Antibiotics | Microscopy | Viruses | Infections | Genomes | FDA approval | Drug dosages | Viral infections
Journal Article
Medical Journal of Australia, ISSN 0025-729X, 11/2018, Volume 209, Issue 10, pp. 449 - 454
Journal Article
Antiviral Therapy, ISSN 1359-6535, 2011, Volume 16, Issue 4, pp. 611 - 614
A 14 year old common variable immunodeficiency patient developed severe protein-losing enteropathy. A chronic enteral infection with human parechovirus type 1... 
TRIALS | INFECTIOUS DISEASES | INFECTIONS | VIROLOGY | EFFICACY | ORAL PLECONARIL | ADULTS | PHARMACOLOGY & PHARMACY
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2004, Volume 14, Issue 10, pp. 2519 - 2525
A series of pyrazolo[3,4-d]pyrimidines were synthesized. and their antiviral activity was evaluated in a plaque reduction assay. It is very interesting that... 
PARALYSIS | PLECONARIL | CHEMISTRY, MEDICINAL | ANTAGONIST | enterovirus inhibitor | CHEMISTRY, ORGANIC | INFECTION | OUTBREAK
Journal Article
Antiviral Therapy, ISSN 1359-6535, 2015, Volume 20, Issue 2, pp. 121 - 130
The enteroviruses (EVs) of the Picornaviridae family are the most common viral pathogens known. Most EV infections are mild and self-limiting but... 
INFECTIOUS DISEASES | COMMON COLD | PLECONARIL THERAPY | INFLUENZA | ANTIMICROBIAL RESISTANCE | IN-VITRO | VIROLOGY | POLIOVIRUS | MOUTH-DISEASE | HOMOSEXUAL-MEN | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | RHINOVIRUS INFECTION
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 07/2013, Volume 4, Issue 7, pp. 585 - 589
Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other... 
HCV | enterovirus | inhibitor | PI4KIIIβ | antiviral | C VIRUS-REPLICATION | PLECONARIL | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | PI4KIII beta | ALPHA | RHINOVIRUS COLDS | BETA | DOUBLE-BLIND | EXACERBATIONS | INHIBITORS
Journal Article