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1. Full Text Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review
by Ford Versypt, Ashlee N and Pack, Daniel W and Braatz, Richard D
Journal of Controlled Release, ISSN 0168-3659, 01/2013, Volume 165, Issue 1, pp. 29 - 37
PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and... 
Bulk degradation | Controlled release drug delivery | Degradable polymer | PLGA | Autocatalysis | Modeling | MOLECULAR-WEIGHT | BIODEGRADABLE MICROSPHERES | HYDROLYTIC DEGRADATION | CONTROLLED-RELEASE | POLY(LACTIC-CO-GLYCOLIC ACID) FILMS | CHEMISTRY, MULTIDISCIPLINARY | ALIPHATIC POLYESTERS | BIOERODIBLE POLYMER MATRICES | PHARMACOLOGY & PHARMACY | RESORBABLE DEVICE DEGRADATION | MICROCLIMATE PH | BULK EROSION | Models, Theoretical | Microspheres | Lactic Acid - chemistry | Polyglycolic Acid - chemistry | Drug Delivery Systems | Hydrolysis | Drugs | Drug delivery systems | Analysis | Models | Polymers | Vehicles | Controlled release | controlled release drug delivery | modeling | bulk degradation | autocatalysis | degradable polymer
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2. Full Text Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease
by Garbayo, E and Montero-Menei, C.N and Ansorena, E and Lanciego, J.L and Aymerich, M.S and Blanco-Prieto, M.J
Journal of Controlled Release, ISSN 0168-3659, 2009, Volume 135, Issue 2, pp. 119 - 126
Glial cell line-derived neurotrophic factor (GDNF) has shown promise in the treatment of neurodegenerative disorders of basal ganglia origin such us... 
TROMS | PLGA microparticles | Parkinson's disease | GDNF | Serum IgG antibodies against GDNF | SYSTEM | BIOCOMPATIBILITY | BIODEGRADABLE MICROSPHERES | RAT | NEUROTROPHIC FACTOR | INFUSION | DOPAMINERGIC-NEURONS | MICROPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | PRIMATE MODELS | IMPLANTATION | PHARMACOLOGY & PHARMACY | Immunohistochemistry | Parkinson Disease - therapy | PC12 Cells | Drug Carriers - chemistry | Drug Delivery Systems | Brain - metabolism | Recombinant Proteins - isolation & purification | Microspheres | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Glial Cell Line-Derived Neurotrophic Factor - ultrastructure | Female | Fluorescent Antibody Technique, Indirect | Disease Models, Animal | Recombinant Proteins - metabolism | Lactic Acid - chemistry | Glial Cell Line-Derived Neurotrophic Factor - genetics | Rats | Glycosylation | Glial Cell Line-Derived Neurotrophic Factor - adverse effects | Glial Cell Line-Derived Neurotrophic Factor - administration & dosage | Rats, Sprague-Dawley | Particle Size | Animals | Cell Differentiation - drug effects | Polyglycolic Acid - chemistry | Corpus Striatum - drug effects | Kinetics | Models, Neurological | Animal behavior | Immunoglobulin G | Analysis
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3. Full Text Evaluation of in vivo– in vitro release of dexamethasone from PLGA microspheres
by Zolnik, Banu S and Burgess, Diane J
Journal of Controlled Release, ISSN 0168-3659, 2008, Volume 127, Issue 2, pp. 137 - 145
Two poly(lactic- -glycolic acid) (PLGA) microsphere formulations, with different polymer molecular weights were investigated to determine whether an and... 
USP apparatus | Drug delivery | In vivo– in vitro relationship | PLGA microspheres | Dexamethasone | In vivo-in vitro relationship | dexamethasone | PLA | in vivo-in vitro relationship | DRUG-RELEASE | NERVE BLOCKADE | drug delivery | MICROPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | INSULIN | SOMATOSTATIN ANALOG | TEMPERATURE | DEGRADATION | PHARMACOLOGY & PHARMACY | ACID) MICROSPHERES | Dexamethasone - chemistry | Inflammation - pathology | Lactic Acid - chemistry | Anti-Inflammatory Agents - pharmacology | Polyglycolic Acid - pharmacology | Rats | Male | Rats, Sprague-Dawley | Drug Carriers - chemistry | Drug Carriers - pharmacology | Dexamethasone - pharmacokinetics | Lactic Acid - pharmacokinetics | Microspheres | Inflammation - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Dexamethasone - pharmacology | Polyglycolic Acid - pharmacokinetics | Inflammation - drug therapy | Polyglycolic Acid - chemistry | Anti-Inflammatory Agents - pharmacokinetics | Drug Carriers - pharmacokinetics | Lactic Acid - pharmacology | Drugs | Drug delivery systems | Analysis | Steroids | Vehicles
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4. Full Text Engineering vascularized soft tissue flaps in an animal model using human adipose – derived stem cells and VEGF+PLGA/PEG microspheres on a collagen-chitosan scaffold with a flow-through vascular pedicle
by Zhang, Qixu and Hubenak, Justin and Iyyanki, Tejaswi and Alred, Erik and Turza, Kristin C and Davis, Greg and Chang, Edward I and Branch-Brooks, Cynthia D and Beahm, Elisabeth K and Butler, Charles E
Biomaterials, ISSN 0142-9612, 2015, Volume 73, pp. 198 - 213
Abstract Insufficient neovascularization is associated with high levels of resorption and necrosis in autologous and engineered fat grafts. We tested the... 
Advanced Basic Science | Dentistry | Soft tissue flap engineering | PLGA/PEG microsphere | Collagen-chitosan scaffold | Adipose-derived stem cell | Vascular endothelial growth factor | Vascularization | Immunohistochemistry | Surgical Flaps | Cell Proliferation | Humans | Culture Media, Conditioned - chemistry | Adipocytes - cytology | Collagen - chemistry | Polyethylene Glycols - chemistry | Stem Cells - cytology | Rats, Nude | Tissue Scaffolds | Vascular Endothelial Growth Factor A - chemistry | Microspheres | Female | Green Fluorescent Proteins - chemistry | Microscopy, Electron, Scanning | Lactic Acid - chemistry | Tissue Engineering - methods | Cell Survival | Rats | Macrophages - cytology | Aorta - pathology | Silicones - chemistry | Animals | Chitosan - chemistry | Polyglycolic Acid - chemistry | Microscopy, Fluorescence | Neovascularization | Collagen | Analysis | Stem cells | Surgery, Plastic | Endothelium | Adipose tissues | Surgical implants | Flaps | Construction | Polyethylene glycol | Scaffolds | Soft tissues | PLGA | PEG microsphere
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5. Full Text Comparison of in vitro–in vivo release of Risperdal® Consta® microspheres
by Rawat, Archana and Bhardwaj, Upkar and Burgess, Diane J
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2012, Volume 434, Issue 1-2, pp. 115 - 121
– relationship between accelerated release and absorption profiles (time scaled) of Risperdal Consta 25 mg long acting injection (risperidone microspheres).... 
USP apparatus 4 | In vitro–in vivo relationship (IVIVR) | PLGA microspheres | Accelerated in vitro release | In vitro-in vivo relationship (IVIVR) | DRUG-RELEASE | RISPERIDONE | MECHANISMS | IMPLANTS | PHARMACOKINETICS | TEMPERATURE | KINETICS | DEGRADATION | PHARMACOLOGY & PHARMACY | Temperature | Lactic Acid - chemistry | Humans | Risperidone - administration & dosage | Risperidone - chemistry | Phase Transition | Drug Carriers - chemistry | Microspheres | Time Factors | Polyglycolic Acid - chemistry | Delayed-Action Preparations | Hydrogen-Ion Concentration | Quality Control
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6. Full Text Heterogeneous hydrolytic degradation of poly(lactic‐co‐glycolic acid) microspheres: Mathematical modeling
by Busatto, Carlos and Pesoa, Juan and Helbling, Ignacio and Luna, Julio and Estenoz, Diana
Journal of Applied Polymer Science, ISSN 0021-8995, 11/2017, Volume 134, Issue 43, pp. 45464 - n/a
A new mathematical model for the prediction of the heterogeneous hydrolytic degradation of poly(D,L‐lactide‐ co ‐glycolide) (PLGA)‐based microspheres was... 
biodegradable | degradation | drug‐delivery systems | theory and modeling | drug-delivery systems | POLYMER SCIENCE | MOLECULAR-WEIGHT | ENCAPSULATION | RELEASE | MICROPARTICLES | POLYMER DEGRADATION | AUTOCATALYSIS | BIODEGRADABLE POLYMERS | ALIPHATIC POLYESTERS | LOADED PLGA MICROSPHERES | Hydrolysis | Degradation | Microspheres | Particle size | Mathematical analysis | Morphology | Glycolic acid | Mathematical models | Composition effects | Molecular weight
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7. Full Text Development of a single dose tetanus toxoid formulation based on polymeric microspheres: a comparative study of poly( d, l-lactic-co-glycolic acid) versus chitosan microspheres
by Jaganathan, K.S and Rao, Y.U.B and Singh, Paramjit and Prabakaran, D and Gupta, Swati and Jain, Anubhav and Vyas, Suresh P
International Journal of Pharmaceutics, ISSN 0378-5173, 2005, Volume 294, Issue 1, pp. 23 - 32
Stable polymeric microspheres capable of controlled release of tetanus toxoid (TT) for periods ranging from days to over months were developed. TT was... 
Protein stability | PLGA microspheres | Chitosan microspheres | Tetanus toxoid | Single shot vaccine | BIODEGRADABLE MICROSPHERES | DELIVERY SYSTEMS | STABILITY | STABILIZATION | VACCINE | ENCAPSULATION | chitosan microspheres | CONTROLLED-RELEASE | protein stability | KINETICS | PHARMACOLOGY & PHARMACY | single shot vaccine | tetanus toxoid | ANTIGEN | Polymers - administration & dosage | Guinea Pigs | Lactic Acid - chemistry | Drug Administration Schedule | Chitosan - administration & dosage | Male | Chemistry, Pharmaceutical | Tetanus Toxoid - administration & dosage | Dose-Response Relationship, Drug | Microspheres | Animals | Chitosan - chemistry | Tetanus Toxoid - chemistry | Polyglycolic Acid - chemistry | Polymers - chemistry | Lactic Acid - administration & dosage | Polyglycolic Acid - administration & dosage | Drugs | Antigens | Drug delivery systems | Biological products | Antibodies | Vehicles | Viral antibodies | Analysis | Dosage and administration | Tetanus | Polymers | Alum | Antacids
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8. Full Text The microclimate pH in poly( d , l -lactide-co-hydroxymethyl glycolide) microspheres during biodegradation
by Liu, Yajun and Ghassemi, Amir H and Hennink, Wim E and Schwendeman, Steven P
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 30, pp. 7584 - 7593
Abstract The microclimate pH (μpH) in biodegradable polymers, such as poly( d , l -lactic-co-glycolic acid) (PLGA) 50/50, commonly falls to deleterious acidic... 
Advanced Basic Science | Dentistry | Microclimate pH | Hydrophilic polyesters | Microsphere | pH distribution | Poly(lactic-co-glycolic acid) | Confocal laser scanning microscopy | PH distribution | MATERIALS SCIENCE, BIOMATERIALS | POLY(LACTIC-CO-GLYCOLIC ACID) MICROPARTICLES | ENGINEERING, BIOMEDICAL | STABILIZATION | STABILITY | RELEASE | MICROSCOPY | FUNCTIONALIZED POLY(ALPHA-HYDROXY ACID)S | DELIVERY | HUMAN GROWTH-HORMONE | PLGA MICROSPHERES | POLY(LACTIDE-CO-GLYCOLIDE) | Biodegradation, Environmental | Boron Compounds - chemistry | Microscopy, Electron, Scanning | Lactic Acid - chemistry | Acids - chemistry | Solubility | Chemistry, Pharmaceutical | Microscopy, Confocal | Microspheres | Polyesters - chemistry | Solutions | Polyglycolic Acid - chemistry | Water - chemistry | Kinetics | Diffusion | Hydrogen-Ion Concentration | Proteins | Biodegradation | Physiological aspects | Biological products | Hydrogen-ion concentration | microsphere | hydrophilic polyesters | poly(lactic-co-glycolic acid) | microclimate pH | confocal laser scanning microscopy
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9. Full Text Gas foamed open porous biodegradable polymeric microspheres
by Kim, Taek Kyoung and Yoon, Jun Jin and Lee, Doo Sung and Park, Tae Gwan
Biomaterials, ISSN 0142-9612, 2006, Volume 27, Issue 2, pp. 152 - 159
Highly open porous biodegradable polymeric microspheres were fabricated for use as injectable scaffold microcarriers for cell delivery. A modified... 
Biodegradation | Microspheres | Gas foaming | PLGA | Biodegradable polymer | Polylactic acid | Scaffold | Microcarrier | Porous | ATTACHMENT | MATERIALS SCIENCE, BIOMATERIALS | PROTEIN | microspheres | ENGINEERING, BIOMEDICAL | biodegradable polymer | biodegradation | porous | microcarrier | COMPOSITES | gas foaming | CARTILAGE | polylactic acid | scaffold | MACROPOROUS MICROCARRIERS | GROWTH | SURFACE | ACID) MICROSPHERES | SCAFFOLDS | POROGEN | NIH 3T3 Cells | Cell Proliferation | Lactic Acid - chemistry | Emulsions - chemistry | Solvents - chemistry | Biocompatible Materials - chemistry | Materials Testing | Absorbable Implants | Drug Carriers | Particle Size | Gases | Animals | Cattle | Polyglycolic Acid - chemistry | Surface Properties | Polymers - chemistry | Bicarbonates - chemistry | Mice | Biological products | Carbonates | Biopolymers
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10. Full Text Recent advances in polymeric microspheres for parenteral drug delivery - part 1
by Mao, Shirui and Guo, Chunqiang and Shi, Yi and Li, Luk Chiu
Expert Opinion on Drug Delivery, ISSN 1742-5247, 09/2012, Volume 9, Issue 9, pp. 1161 - 1176
Introduction: Polymeric microspheres have been established as a valuable parenteral drug delivery system for sustained release of therapeutic agents via... 
parenteral drug delivery | microsphere formulations | microsphere characterization | polymeric microspheres | Microsphere formulations | Microsphere characterization | Parenteral drug delivery | Polymeric microspheres | IN-VITRO RELEASE | POLY(D,L-LACTIDE-CO-GLYCOLIDE) MICROSPHERES | VIVO EVALUATION | LOADED CHITOSAN MICROSPHERES | POLYHYDROXYBUTYRATE MICROSPHERES | OF-THE-ART | DEGRADABLE STARCH MICROSPHERES | DOUBLE EMULSION PROCESS | PLGA MICROSPHERES | PHARMACOLOGY & PHARMACY | SUSTAINED-RELEASE | Infusions, Parenteral | Microspheres | Polymers - chemistry | Animals | Humans | Drug Delivery Systems
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11. Full Text Development and evaluation of novel biodegradable microspheres based on poly( d, l-lactide- co-glycolide) and poly(ε-caprolactone) for controlled delivery of doxycycline in the treatment of human periodontal pocket: In vitro and in vivo studies
by Mundargi, Raghavendra C and Srirangarajan, S and Agnihotri, Sunil A and Patil, Sangamesh A and Ravindra, S and Setty, Swati B and Aminabhavi, Tejraj M
Journal of Controlled Release, ISSN 0168-3659, 2007, Volume 119, Issue 1, pp. 59 - 68
This study reports on the development of novel biodegradable microspheres prepared by water-in-oil–water (W/O/W) double emulsion technique using the blends of... 
PCL | Microspheres | Blends | PLGA | Doxycycline | Periodontal pocket | TETRACYCLINE HYDROCHLORIDE | periodontal pocket | microspheres | POLYMER BLENDS | DRUG-RELEASE | doxycycline | MICROPARTICLES | PLAQUE | CHEMISTRY, MULTIDISCIPLINARY | EVAPORATION | POLY(ETHYLENE GLYCOL) | POLY(LACTIC ACID) | PHARMACOLOGY & PHARMACY | MICROENCAPSULATION | SUSTAINED-RELEASE | blends | Polymers - administration & dosage | Humans | Doxycycline - pharmacokinetics | Random Allocation | Periodontal Pocket - drug therapy | Lactic Acid - pharmacokinetics | Polyesters - pharmacokinetics | Doxycycline - administration & dosage | Polyglycolic Acid - pharmacokinetics | Polyesters - administration & dosage | Periodontal Pocket - pathology | Polymers - pharmacokinetics | Drug Evaluation, Preclinical | Drug Delivery Systems - methods | Lactic Acid - administration & dosage | Polyglycolic Acid - administration & dosage | Periodontal Pocket - metabolism | Analysis
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12. Full Text PHBV microspheres – PLGA matrix composite scaffold for bone tissue engineering
by Huang, Wei and Shi, Xuetao and Ren, Li and Du, Chang and Wang, Yingjun
Biomaterials, ISSN 0142-9612, 2010, Volume 31, Issue 15, pp. 4278 - 4285
Abstract Polymer scaffolds, particularly in the form of microspheres, have been employed to support cells growth and deliver drugs or growth factors in tissue... 
Advanced Basic Science | Dentistry | PHBV | Bone repair | PLGA | Microsphere | Scaffold | Tissue engineering | OSTEOBLAST | MATERIALS SCIENCE, BIOMATERIALS | INDUCED PHASE-SEPARATION | FIBROBLAST | ENGINEERING, BIOMEDICAL | INVITRO | CHITOSAN | TOPOGRAPHY | ADHESION | REPAIR | GROWTH | POLY(3-HYDROXYBUTYRATE-CO-3-HYDROXYHEXANOATE) | Microscopy, Electron, Scanning | Bone and Bones - physiology | Lactic Acid - chemistry | Tissue Engineering - methods | Cell Survival | Biocompatible Materials - chemistry | Humans | Cells, Cultured | Drug Delivery Systems | Tissue Scaffolds - chemistry | Compressive Strength | Particle Size | Microspheres | Polyesters - chemistry | Tissue Engineering - instrumentation | Mesenchymal Stromal Cells - cytology | Cell Adhesion - physiology | Polyglycolic Acid - chemistry | Porosity | Mesenchymal Stromal Cells - physiology
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13. Full Text Characterization of biodegradable chitosan microspheres containing vancomycin and treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with prepared microspheres
by Cevher, Erdal and Orhan, Zafer and Mülazımoğlu, Lütfiye and Şensoy, Demet and Alper, Murat and Yıldız, Ayca and Özsoy, Yıldız
International Journal of Pharmaceutics, ISSN 0378-5173, 2006, Volume 317, Issue 2, pp. 127 - 135
The biodegradable chitosan microspheres containing vancomycin hydrochloride (VANCO) were prepared by spray drying method with different polymer:drug ratios... 
Experimental osteomyelitis | Vancomycin | Chitosan | Biodegradable microspheres | Methicillin-resistant Staphylococcus aureus | Spray drying method | MRSA OSTEOMYELITIS | chitosan | TOPICAL VANCOMYCIN | ANTIBIOTIC RELEASE | IMPLANT-RELATED OSTEOMYELITIS | methicillin-resistant Staphylococcus aureus | TREATING OSTEOMYELITIS | DELIVERY-SYSTEM | spray drying method | IN-VITRO | biodegradable microspheres | vancomycin | PECTIN MICROSPHERES | PLGA MICROSPHERES | PHARMACOLOGY & PHARMACY | experimental osteomyelitis | BIOABSORBABLE POLYMER | Rats, Wistar | Staphylococcal Infections - pathology | Drug Implants | Male | Colony Count, Microbial | Osteomyelitis - drug therapy | Anti-Bacterial Agents - therapeutic use | Microspheres | Vancomycin - chemistry | Anti-Bacterial Agents - chemistry | Osteomyelitis - pathology | Drug Compounding | Staphylococcal Infections - microbiology | Methicillin Resistance | Disease Models, Animal | Biodegradation, Environmental | Staphylococcal Infections - drug therapy | Vancomycin - administration & dosage | Staphylococcus aureus - isolation & purification | Rats | Injections, Intramuscular | Particle Size | Animals | Chitosan - chemistry | Osteomyelitis - microbiology | Vancomycin - therapeutic use | Staphylococcus aureus - drug effects | Anti-Bacterial Agents - administration & dosage | Osteomyelitis | Drug resistance in microorganisms | Medical colleges | Analysis | Staphylococcal infections | Pharmacy | Polymers | Staphylococcus aureus
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