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HEPATOLOGY, ISSN 0270-9139, 12/2017, Volume 66, Issue 6, pp. 1750 - 1765
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC) and current treatments for chronic hepatitis B and HCC are... 
PLK1 | GASTROENTEROLOGY & HEPATOLOGY | CORE PROTEIN
Journal Article
FUTURE MEDICINAL CHEMISTRY, ISSN 1756-8919, 03/2019, Volume 11, Issue 12, pp. 1383 - 1386
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2017, Volume 37, Issue 9
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 01/2020, Volume 521, Issue 4, pp. 833 - 839
Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that could simultaneously bind to the target protein and the E3 ubiquitin ligase,... 
Journal Article
Journal of Bone Oncology, ISSN 2212-1374, 12/2019, Volume 19, p. 100268
Chondrosarcomas are malignant cartilage tumors that are relatively resistant towards conventional therapeutic approaches. Kinase inhibitors have been... 
Chondrosarcoma | CHK1 | Screen | PLK1 | AURKA
Journal Article
Cancer Letters, ISSN 0304-3835, 05/2018, Volume 422, pp. 70 - 80
Circular RNAs (CircRNAs) are a novel type of endogenous noncoding RNAs that regulate target gene expression by interacting with microRNA (miRNA). Emerging... 
miR-874-3p | ceRNAs | PLK1 | hsa_circ_0000977 | PDAC proliferation | PATHWAYS | TARGET | POLO-LIKE KINASES | MICRORNAS | GEMCITABINE RESISTANCE | ONCOLOGY | CANCER-DIAGNOSIS | PHASE-I
Journal Article
Cell Cycle, ISSN 1538-4101, 03/2015, Volume 14, Issue 5, pp. 755 - 760
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2015, Volume 6, p. 253
Repair of DNA lesions through homologous recombination promotes the establishment of stable chromosomal interactions. Multiple helicases, topoisomerases and... 
Holliday junction | Recombination | Replication | Cdc14 | Cdc5/PLK1 | Cdk | Nuclease | DNA repair | replication | Cdk1 | recombination | Cdc5 | DNA Repair
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 03/2017, Volume 27, Issue 5, pp. 1311 - 1315
Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]Apteridine PLK1 inhibitors. Rational improvements to compounds of... 
CELLS | CHEMISTRY, MEDICINAL | Structure-based drug design | Multidrug resistance | PLK1 | TAK-960 | CHEMISTRY, ORGANIC | DEPLETION | CANCER-THERAPY | DROSOPHILA | MITOSIS | SELECTIVE INHIBITOR | ONCOLOGY | Antitumor activity | TUMOR-GROWTH | PLK1 inhibitor
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 517 - 528
Both PLK1 and EEF2K are serine⁄threonine kinases that play important roles in the proliferation and programmed cell death of various types of cancer. They are... 
Breast cancer | EEF2K | Autophagy | Kinase inhibitor | PLK1 | Apoptosis | CHEMISTRY, MEDICINAL | PROTEIN | SOLID TUMORS | 3D-QSAR | MULTICOMPLEX-BASED PHARMACOPHORE | MOLECULAR DOCKING | DISCOVERY | POTENT ACTIVITY | IN-VITRO | PLK1 INHIBITORS | DERIVATIVES
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 30, pp. 21231 - 21243
BI2536 has been developed as a potential therapeutic agent for various cancers but not in oral cancer cells. Since BI2536 exhibits mitosis-regulating activity... 
Mitotic catastrophe | BI2536 | Radiosensitization | Oral cancer | PLK1
Journal Article
Cell Reports, ISSN 2211-1247, 02/2015, Volume 10, Issue 5, pp. 664 - 673
The primary cilium is an antenna-like, microtubule-based organelle on the surface of most vertebrate cells for receiving extracellular information. Although... 
SPINDLE CHECKPOINT | CENTRIOLE | PLK1 | BUBR1 | BUB1B | CILIOGENESIS | MUTATIONS | IDENTIFICATION | CENTROSOMES | CELL BIOLOGY
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2019, Volume 91, p. 103148
A series of new peptidomimetics targeting the polo-box domain (PBD) of polo-like kinase 1 (Plk1) was identified based on the potent and selective pentapeptide... 
Polo-box domain | Plk1 PBD | Inhibitors | Polo-like kinase 1 | Unnatural amino acid | DESIGN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-AFFINITY | PLK1 | CHEMISTRY, ORGANIC | PEPTIDE
Journal Article
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