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Development (Cambridge), ISSN 0950-1991, 01/2017, Volume 144, Issue 2, pp. 175 - 186
Journal Article
Cell stem cell, ISSN 1934-5909, 04/2016, Volume 18, Issue 4, pp. 481 - 494
The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic... 
methylation is sufficient to drive reprogramming to | are instead simply a reflection of discrete pluripotent | we show that blocking histone H3K4 | with more | findings show that discrete perturbation of H3K4 | it is unclear whether | determinant factors and EpiSC markers | indirectly regulate ESC transcription circuitry. These | naive embryonic stem cells (ESCs) within 3 days. Reverted | INDUCTION | naive pluripotency | The interconversion between naive and primed | competent chimeras | CELL BIOLOGY | generating germline | GROUND-STATE PLURIPOTENCY | ESCs reactivate the silenced X chromosome | PRIMED PLURIPOTENCY | pluripotent states is accompanied by drastic epigenetic | Importantly | H3K4 METHYLTRANSFERASE ACTIVITY | is highly efficient and synchronized | than 50% of treated EpiSCs exhibiting features of | which | of H3K4me1 at enhancers and represses lineage | and contribute to embryos following blastocyst injection | MOUSE EMBRYOS | inhibitor MM-401 reprograms mouse epiblast | to naive pluripotency or if distinct chromatin states | SELF-RENEWAL | states. Here | ACETYLTRANSFERASE MOF | CELL & TISSUE ENGINEERING | rearrangements. However | PRIMITIVE STREAK | CORE TRANSCRIPTIONAL NETWORK | methyltransferase MLL1 activity with the small | intrinsic epigenetic events can drive reprogramming | blocking MLL1 leads to global redistribution | X-CHROMOSOME INACTIVATION | molecule | stem cells (EpiSCs) to naive pluripotency. This reversion | Cell Line | Small Molecule Libraries - pharmacology | Germ Layers - drug effects | Myeloid-Lymphoid Leukemia Protein - metabolism | Myeloid-Lymphoid Leukemia Protein - deficiency | Histone-Lysine N-Methyltransferase - deficiency | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Cellular Reprogramming - drug effects | Pluripotent Stem Cells - metabolism | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Animals | Histone-Lysine N-Methyltransferase - metabolism | Pluripotent Stem Cells - drug effects | Mice | Oligopeptides - pharmacology | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 12, p. e0210042
[This corrects the article DOI: 10.1371/journal.pone.0206844.]. 
Clustering | Regulators | Pluripotency
Journal Article
Molecular human reproduction, ISSN 1460-2407, 2018, Volume 24, Issue 11, pp. 543 - 555
STUDY QUESTION: What are the transcriptional changes occurring during the human embryonic stem cell (hESC) derivation process, from the inner cell mass (ICM)... 
transcriptional profiling | primed | signaling | naïve | post-inner cell mass-intermediate stage | inner cell mass | pluripotency | LONG NONCODING RNAS | NAIVE PLURIPOTENCY | SELF-RENEWAL | DEVELOPMENTAL BIOLOGY | INDUCTION | ESTABLISHMENT | OBSTETRICS & GYNECOLOGY | REPRODUCTIVE BIOLOGY | STATE PLURIPOTENCY | MASS | GENE-EXPRESSION | DIFFERENTIATION | naive | PROGRESSION
Journal Article