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plx4032 (103) 103
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ONCOTARGETS AND THERAPY, ISSN 1178-6930, 2017, Volume 10, pp. 965 - 971
Background: Mutations in the BRAF gene have been implicated in several human cancers. The objective of this screening study was to identify patients with solid... 
proto-oncogene proteins B-raf | PLX4032 | ADENOCARCINOMA | BRAF V600E MUTATION | TRIAL | HAIRY-CELL LEUKEMIA | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | genetic testing | PROSTATE-CANCER | KRAS | VEMURAFENIB
Journal Article
by Kim, SH and Kang, JG and Kim, CS and Ihm, SH and Choi, MG and Yoo, HJ and Lee, SJ
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, ISSN 0391-4097, 12/2013, Volume 36, Issue 11, pp. 1099 - 1104
Aim of the present study was to evaluate the effect of apigenin in combination with BRAF(V600E) inhibitor PLX4032 on cell survival, and to investigate the... 
APOPTOSIS | PLX4032 | PHOSPHORYLATION | apigenin | BRAF | FLAVONOIDS | DEATH | Akt | CANCER | P21 | Anaplastic thyroid carcinoma | MELANOMA | BRAF MUTATION | PATHWAY | GROWTH | ENDOCRINOLOGY & METABOLISM
Journal Article
Oncotarget, ISSN 1949-2553, 2014, Volume 5, Issue 8, pp. 2085 - 2095
SIRT1 operates as both a tumor suppressor and oncogenic factor depending on the cell context. Whether SIRT1 plays a role in melanoma biology remained poorly... 
MITF | Treatment | PLX4032 | SIRT1 | Melanoma | Index Medicus
Journal Article
CURRENT ONCOLOGY, ISSN 1198-0052, 02/2014, Volume 21, Issue 1, pp. E151 - E154
Mismatch-repair-deficient colorectal cancers often contain kinase-activating V600E BRAF mutations, but no clinical utility has yet been demonstrated in this... 
genomic profiling | PLX4032 | combination drug therapy | Colorectal neoplasms | COLON-CANCER | TRIAL | BRAF V600E | personalized oncology | MELANOMA | INHIBITION | ONCOLOGY | PATHWAY | RAF | RESISTANCE | precision medicine | MUTATIONS
Journal Article
Immunologic Research, ISSN 0257-277X, 8/2011, Volume 50, Issue 2, pp. 294 - 302
PLX4032 is a BRAF-selective inhibitor shown to be efficacious in the treatment of melanomas presenting with the BRAFV600E mutation. However, favorable... 
Allergology | Signaling pathways | Immunology | Medicine & Public Health | Melanoma | Internal Medicine | CSPG4-specific mAb | BRAF inhibitor resistance | Medicine/Public Health, general | BRAF inhibitor PLX4032 | SURVIVAL | COLLAGEN | PLX4032 | ACQUIRED-RESISTANCE | SENSITIVITY | NG2 PROTEOGLYCAN | IMMUNOLOGY | ANTIGEN HMW-MAA | THERAPY | PATHWAY | IMMUNOTHERAPY | Chondroitin Sulfate Proteoglycans - genetics | Membrane Proteins - genetics | Antibodies, Monoclonal - pharmacology | Humans | Chondroitin Sulfate Proteoglycans - antagonists & inhibitors | Membrane Proteins - immunology | Down-Regulation - drug effects | Mutation - genetics | Sulfonamides - pharmacology | Chondroitin Sulfate Proteoglycans - immunology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Melanoma - immunology | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Indoles - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Antibodies, Monoclonal - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Viral antibodies | Gene mutations | Analysis | Monoclonal antibodies | Antibodies | Sulfates | Cells | Cancer | Index Medicus | Signal transduction | Cell survival | Proteoglycans | Data processing | Remission | Chondroitin sulfate | Longevity | Mutation | Cell migration
Journal Article
BMC Cancer, ISSN 1471-2407, 05/2015, Volume 15, Issue 1, pp. 356 - 356
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2011, Volume 404, Issue 4, pp. 958 - 962
► Exciting therapeutic potential has been recently reported for the BRAF inhibitor PLX4032 in melanoma. ► We tested the effects of PLX4032 on the growth of... 
Genetic-dependent therapy | Thyroid cancer | PLX4032 | BRAF inhibitor | RG7204 | BRAF mutation
Journal Article
LEUKEMIA RESEARCH, ISSN 0145-2126, 11/2015, Volume 39, Issue 11, pp. 1270 - 1277
A subset of patients with chronic lymphocytic leukemia (CLL) and nearly all patients with classic hairy cell leukemia (HCL) harbor somatic BRAF activating... 
ABCB1 | PLX4032 | B-cell | Leukemia | BRAF V600E MUTATION | BRAF | P-GLYCOPROTEIN EXPRESSION | PROLIFERATION | Lymphoma | P-glycoprotein | COLON-CANCER | Vemurafenib | METASTATIC MELANOMA | PROTEIN ABCG2 | ONCOLOGY | PATHWAY | CHRONIC LYMPHOCYTIC-LEUKEMIA | INHIBITOR VEMURAFENIB | HEMATOLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53733 - e53733
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 2/2017, Volume 26, Issue 2, pp. 390 - 396
BRAFV600E small-molecule inhibitors have recently received increasing attention as very effective agents for the therapy of cancer, especially melanoma. In... 
Biochemistry, general | BRAF V600E | Binding free energy calculation | Biomedicine | Molecular dynamics (MD) | PLX4032·PLX4720 | Pharmacology/Toxicology | Cell Biology | BRAF | Molecular dynamics | Ligands
Journal Article
Molecules, ISSN 1420-3049, 08/2018, Volume 23, Issue 8, p. 2019
Many studies have demonstrated that berberine inhibited the cell migration and invasion in human cancer cell lines. However, the exact molecular mechanism of... 
Berberine | PLX4032 | Migration | Invasion | Human melanoma A375.S2 | RAF INHIBITOR | APOPTOSIS | TUMOR INVASION | ACTIVATION | METASTASIS | human melanoma A375.S2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MALIGNANT-MELANOMA | CHEMISTRY, MULTIDISCIPLINARY | berberine | EPITHELIAL-MESENCHYMAL TRANSITION | MATRIX METALLOPROTEINASES | invasion | PROSTATE-CANCER CELLS | migration | GENE-EXPRESSION | Melanoma - metabolism | Cell Survival - drug effects | Cell Proliferation | Humans | NF-kappa B - metabolism | Melanoma - pathology | Berberine - pharmacology | Cell Movement - drug effects | Neoplasm Metastasis | Signal Transduction - drug effects | Cell Line, Tumor | Matrix Metalloproteinases - metabolism | Focal Adhesion Kinase 1 - metabolism | Drug Resistance, Neoplasm - drug effects | Transcription factors | Low concentrations | Mobility | AKT protein | Skin resistance | Matrix metalloproteinase | E-cadherin | Western blotting | Skin cancer | Metastases | Cell adhesion & migration | N-Cadherin | Gelatin | Inhibition | Interstitial collagenase | Wound healing | Melanoma | Extracellular signal-regulated kinase | c-Jun protein | Tumor cell lines | Collagenase 3 | Gelatinase B | 1-Phosphatidylinositol 3-kinase | Grb2 protein | Cell number | Cell lines | Skin | In vivo methods and tests | Mutation | Focal adhesion kinase | Cell migration | Cancer | Index Medicus
Journal Article
by Xu, ZJ and Yan, GR and Wang, GH and Li, B and Zhu, JM and Sun, P and Zhang, XD and Luo, C and Wang, HY and Zhu, WL
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 09/2012, Volume 22, Issue 17, pp. 5428 - 5437
In this study for searching novel B-Raf(V600E) inhibitors, pharmacophore-based virtual screening identified 1 as a hit bearing... 
CHEMISTRY, MEDICINAL | MECHANISM | PLX4032 | KINASE | CHEMISTRY, ORGANIC | BRAF | DISCOVERY | BRAF(V600E) | MELANOMA | B-Raf(V600E) inhibitors | Substructure search | RESISTANCE | Docking | B-RAF | MUTATIONS | Pharmacophore
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 03/2014, Volume 27, Issue 2, pp. 253 - 262
Journal Article
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