X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2105) 2105
Publication (407) 407
Book Chapter (38) 38
Book Review (16) 16
Dissertation (10) 10
Conference Proceeding (5) 5
Data Set (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1221) 1221
humans (1203) 1203
polo-like kinase (883) 883
animals (753) 753
cell biology (738) 738
protein-serine-threonine kinases - metabolism (672) 672
cell cycle proteins - metabolism (653) 653
phosphorylation (647) 647
cell cycle (593) 593
mitosis (575) 575
polo-like kinase 1 (560) 560
cancer (545) 545
proto-oncogene proteins - metabolism (511) 511
biochemistry & molecular biology (493) 493
oncology (463) 463
kinases (401) 401
plk1 (394) 394
proteins (387) 387
polo-like kinase-1 (382) 382
apoptosis (372) 372
protein-serine-threonine kinases - genetics (370) 370
cell cycle proteins - genetics (353) 353
protein-serine-threonine kinases - antagonists & inhibitors (323) 323
cell line, tumor (318) 318
mice (299) 299
cell cycle proteins - antagonists & inhibitors (289) 289
hela cells (288) 288
proto-oncogene proteins - antagonists & inhibitors (288) 288
polo-like kinases (281) 281
female (276) 276
proto-oncogene proteins - genetics (266) 266
expression (249) 249
article (236) 236
gene expression (232) 232
research (232) 232
cell division (231) 231
tumors (184) 184
cell-cycle (181) 181
signal transduction (180) 180
male (179) 179
analysis (177) 177
biology (176) 176
cells (176) 176
polo-like-kinase-1 (176) 176
cytokinesis (175) 175
dna damage (173) 173
cell proliferation (171) 171
multidisciplinary sciences (159) 159
protein (158) 158
protein binding (158) 158
activation (157) 157
genetics & heredity (152) 152
genetic aspects (147) 147
protein-kinase (144) 144
research article (144) 144
chromosomes (143) 143
protein kinase inhibitors - pharmacology (142) 142
rna interference (140) 140
antineoplastic agents - pharmacology (130) 130
cancer-cells (129) 129
mutation (129) 129
localization (126) 126
deoxyribonucleic acid--dna (125) 125
pharmacology & pharmacy (125) 125
phosphotransferases (124) 124
anaphase-promoting complex (123) 123
mitosis - physiology (121) 121
binding (119) 119
dna-damage (119) 119
small-molecule inhibitor (119) 119
physiological aspects (117) 117
inhibition (116) 116
medicine (116) 116
protein kinases - metabolism (113) 113
chromosome segregation (112) 112
science (112) 112
box domain (111) 111
amino acid sequence (109) 109
cell line (109) 109
polo (108) 108
centrosome (106) 106
molecular sequence data (105) 105
saccharomyces-cerevisiae (105) 105
health aspects (104) 104
identification (104) 104
cell proliferation - drug effects (103) 103
checkpoint (102) 102
dna (102) 102
mammalian-cells (101) 101
apoptosis - drug effects (100) 100
chemotherapy (99) 99
cycle (99) 99
prognosis (99) 99
developmental biology (97) 97
meiosis (97) 97
models, biological (97) 97
transfection (97) 97
inhibitors (96) 96
protein-serine-threonine kinases - physiology (94) 94
spindle apparatus - metabolism (94) 94
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2114) 2114
Chinese (12) 12
Korean (4) 4
French (3) 3
German (2) 2
Czech (1) 1
Japanese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Reviews Cancer, ISSN 1474-175X, 01/2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11363
No effective targeted therapies exist for cancers with somatic KRAS mutations. Here we develop a synthetic lethal chemical screen in isogenic KRAS-mutant and... 
CELL LUNG-CANCER | SURVIVAL | COMBINATION THERAPY | STRATEGY | MULTIDISCIPLINARY SCIENCES | SYNTHETIC LETHAL INTERACTION | RESISTANCE | MUTATIONS | RAS ONCOGENES | EXPRESSION | REVEALS | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Male | Antineoplastic Agents - administration & dosage | Lung Neoplasms - physiopathology | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | rho-Associated Kinases - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Enzyme Inhibitors - administration & dosage | Cyclin-Dependent Kinase Inhibitor p21 - genetics | rho-Associated Kinases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lung Neoplasms - enzymology | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | rho-Associated Kinases - genetics | Proto-Oncogene Proteins - genetics | Cell Division - drug effects | Animals | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Mutation | Transcription | Polo-like kinase 1 | Lung cancer | Cyclin-dependent kinases | RhoA protein | Kinases | Rho-associated kinase | Cyclin-dependent kinase | Organic chemistry | Synergistic effects | Cyclin-dependent kinase inhibitor p21 | Transfection | DNA microarrays | Polo-like kinase | Rocks | Inhibition | Tumors | Cancer
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2013, Volume 70, pp. 758 - 767
The benzo[ ]pyrimido-[5,4- ]diazepine-6(11 )-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further... 
ERK5 inhibitor | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one | Kinase selectivity | Benzo[e]pyrimido-[5,4-b]diazepine-6(11H)- one | CELLS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | INHIBITOR SELECTIVITY | POLO-LIKE-KINASE-1 | LRRK2 | PARKINSON DISEASE | PROSTATE-CANCER | IN-VIVO | EXPRESSION | CARCINOMA | Protein Kinase Inhibitors - chemical synthesis | Pyrimidines - chemical synthesis | Humans | Cells, Cultured | Azepines - chemical synthesis | Models, Molecular | Structure-Activity Relationship | Mitogen-Activated Protein Kinase 7 - metabolism | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Pyrimidines - chemistry | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Azepines - pharmacology | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Azepines - chemistry | Mitogen-Activated Protein Kinase 7 - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Molecular Structure | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Serine-Threonine Kinases - metabolism | Medical colleges | Phosphotransferases | Epidermal growth factor | PLK, polo-like kinase | EGF, epidermal growth factor | PML, promyelocytic leukemia protein | X-phos, 2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-biphenyl | DIEA, N,N-diisopropylethylamine | DMA, N,N-dimethylacetamide | ERK5, extracelluar-signal-regulated kinase 5 | LRRK2, leucine rich repeat kinase 2 | BMK1, big MAP kinase 1 | ERK5, mitogen-activated protein kinase 7 | RSK, ribosomal S6 kinase | SAR, structure–activity relationship | Pd2(dba)3, tris(dibenzylideneacetone)dipalladium- | HCC, hepatocellular carcinoma | Original | DCAMKL2, doublecortin and CaM kinase-like 2 | MAPK, mitogen-activated protein kinase | MEK5, MAP kinase kinase 5
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 03/2012, Volume 19, Issue 3, pp. 369 - 377
Journal Article