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Cancer research (Chicago, Ill.), ISSN 1538-7445, 04/2013, Volume 73, Issue 12, pp. 3683 - 3691
Replication stress and DNA damage activate the ATR-Chk1 checkpoint signaling pathway that licenses repair and cell survival processes. In this study, we... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Ovarian Neoplasms - pathology | Cell Survival - genetics | Deoxycytidine - pharmacology | Immunoblotting | Sulfones - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | RNA Interference | BRCA1 Protein - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Topotecan - pharmacology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | cdc25 Phosphatases - genetics | Ataxia Telangiectasia Mutated Proteins | Cisplatin - pharmacology | Pyrimidines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Benzimidazoles - pharmacology | Checkpoint Kinase 1 | Pyrazines - pharmacology | BRCA2 Protein - genetics | Deoxycytidine - analogs & derivatives | Index Medicus | homologous recombination | ovarian cancer | Poly(ADP-ribose) polymerase | veliparib | gemcitabine | BRCA1 | cisplatin | BRCA2 | topotecan
Journal Article
Macromolecules, ISSN 0024-9297, 02/2019, Volume 52, Issue 4, pp. 1772 - 1784
We determined the intermolecular interaction potential, V(r), of dense lysozyme solutions, which governs the spatial distribution of the protein molecules and the location of its liquid... 
Polymer Science | Physical Sciences | Science & Technology
Journal Article
Journal Article
Current opinion in biotechnology, ISSN 0958-1669, 02/2002, Volume 13, Issue 1, pp. 52 - 56
.... Recent studies on protein transduction domains have circumvented this barrier, however, and have resulted in the delivery of peptides, full-length proteins, iron beads, liposomes, and radioactive... 
PTD | VP22 | Protein transduction domains | poly-arg | TAT | Antp | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Biochemical Research Methods | Science & Technology | Protein Structure, Tertiary | Animals | Drug Delivery Systems - methods | Humans | Protein Transport | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e102148 - e102148
Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that activation of poly(ADP-ribose)... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Kinase C - genetics | Phosphorylation | Natriuretic Peptide, Brain - metabolism | Heart Failure - physiopathology | Rats, Inbred WKY | Glycogen Synthase Kinase 3 beta | Hypertension - drug therapy | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Heart Failure - prevention & control | Hypertrophy, Left Ventricular - genetics | Piperidines - pharmacology | Forkhead Transcription Factors - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Blood Pressure - drug effects | HSP90 Heat-Shock Proteins - genetics | Hypertension - genetics | Hypertrophy, Left Ventricular - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Heart Failure - etiology | Rats, Inbred SHR | Natriuretic Peptide, Brain - genetics | Signal Transduction | Isoenzymes - genetics | Hypertrophy, Left Ventricular - etiology | Rats | Heart Failure - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Nerve Tissue Proteins - genetics | Poly(ADP-ribose) Polymerase Inhibitors | Hypertension - physiopathology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Glycogen Synthase Kinase 3 - genetics | HSP90 Heat-Shock Proteins - metabolism | Hypertension - complications | Hypertrophy, Left Ventricular - physiopathology | Quinazolines - pharmacology | Heart | Brain | Hsp90 protein | Protein kinase C | Poly(ADP-ribose) | AKT protein | Biochemistry | Congestive heart failure | Kinases | Blood | Medical schools | Proteins | Signal transduction | Ischemia | Ribose | Rodents | Forkhead protein | Blood pressure | Cardiology | Pharmaceutical sciences | Heart failure | Hypertension | Brain natriuretic peptide | Enzymes | AKT1 protein | Echocardiography | Isoenzymes | Complications | Glycogen | Heat shock proteins | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Cardiomyocytes | Medicine | Chemistry | Inhibitors | Collagen | Isoforms | Fibrosis | Ventricle | Laboratory animals | Hypertrophy | Heat shock | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 03/2019, Volume 116, Issue 12, pp. 5721 - 5726
Journal Article
Journal Article
Experimental Hematology, ISSN 0301-472X, 2012, Volume 40, Issue 3, pp. 197 - 206.e1
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease characterized by defects in the DNA damage response and apoptosis. Among the factors involved in... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | Life Sciences & Biomedicine | Hematology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Gamma Rays | Tumor Suppressor Protein p53 - biosynthesis | Oligonucleotide Array Sequence Analysis | Apoptosis - radiation effects | Humans | Neoplasm Proteins - physiology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Poly(ADP-ribose) Polymerases - physiology | RNA, Messenger - biosynthesis | Genes, p53 | Apoptosis Regulatory Proteins - genetics | Tumor Cells, Cultured - radiation effects | Neoplasm Proteins - genetics | Repressor Proteins - metabolism | Neoplasm Proteins - biosynthesis | Repressor Proteins - genetics | Treatment Outcome | Tumor Cells, Cultured - metabolism | Poly(ADP-ribose) Polymerases - biosynthesis | Gene Expression Regulation, Leukemic - radiation effects | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Apoptosis Regulatory Proteins - metabolism | Poly(ADP-ribose) Polymerases - genetics | RNA, Neoplasm - biosynthesis | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Immunoglobulin Variable Region - genetics | DNA Damage | Mutation | Poly (ADP-Ribose) Polymerase-1 | DNA, Neoplasm - radiation effects | Immunoglobulin Heavy Chains - genetics | Enzymes | Chronic lymphocytic leukemia | Tumor proteins | Analysis | Apoptosis | Index Medicus | Poly(ADP-ribose) Polymerases | Repressor Proteins | Gene Expression Regulation, Leukemic | Leukemia, Lymphocytic, Chronic, B-Cell | RNA, Neoplasm | Life Sciences | Apoptosis Regulatory Proteins | Tumor Suppressor Protein p53 | DNA, Neoplasm | Immunoglobulin Heavy Chains | Neoplasm Proteins | Immunoglobulin Variable Region | Tumor Cells, Cultured | RNA, Messenger | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 04/2008, Volume 30, Issue 1, pp. 11 - 25
Journal Article
Journal of applied polymer science, ISSN 0021-8995, 08/2018, Volume 135, Issue 31, pp. 46561 - n/a
ABSTRACT The significance of aggregated protein structures in tuning structures and dielectric polarization of poly(ethylene oxide) (PEO... 
microstructures | dielectric polarization | poly(ethylene oxide) |