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Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6308, pp. aad6872 - aad6872
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular... 
APOPTOSIS | MIGRATION-INHIBITORY FACTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FACTOR MIF | PARTHANATOS | CYTOKINE | ENZYMATIC-ACTIVITY | TAUTOMERASE | IDENTIFICATION | ENDONUCLEASE-G | Chromatin - metabolism | Mitochondria - enzymology | Oxidative Stress | Glutamic Acid - genetics | Humans | Apoptosis - genetics | Macrophage Migration-Inhibitory Factors - metabolism | Deoxyribonucleases - metabolism | Stroke - genetics | Cell Nucleus - enzymology | Macrophage Migration-Inhibitory Factors - genetics | Base Sequence | DNA Fragmentation | DNA Damage - genetics | Macrophage Migration-Inhibitory Factors - chemistry | Active Transport, Cell Nucleus | Intramolecular Oxidoreductases - metabolism | Nucleic Acid Conformation | Apoptosis Inducing Factor - metabolism | Deoxyribonucleases - chemistry | Amino Acid Sequence | Catalytic Domain | Intramolecular Oxidoreductases - chemistry | DNA, Single-Stranded - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Apoptosis Inducing Factor - genetics | Mice, Knockout | Stroke - enzymology | Deoxyribonucleases - genetics | Animals | Intramolecular Oxidoreductases - genetics | Neurons - enzymology | Mice | HeLa Cells | Mutation | Glutamic Acid - toxicity | DNA Cleavage | Glutamic Acid - chemistry | Polymerase chain reaction | DNA damage | Cells | Index Medicus | Cell death | Deoxyribonucleic acid | Activation | Nuclease | Inhibition | Damage accumulation | Nuclei | Diseases
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/2018, Volume 77, Issue 5, pp. 744 - 751
ObjectivesThe enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units to target proteins. This modification can have... 
fibroblasts | cytokines | systemic sclerosis | ADP-RIBOSE POLYMERASE-1 | FIBROSIS | CRITERIA | PROMOTER HYPERMETHYLATION | INHIBITION | PATHWAY | MEDIATOR | TRANSCRIPTION | RHEUMATOLOGY | PARP-1 | EXPRESSION | Skin Diseases - genetics | Fibroblasts - physiology | Skin - metabolism | Humans | Middle Aged | Protein-Serine-Threonine Kinases | Male | Smad3 Protein - metabolism | Young Adult | Adult | Female | Skin - pathology | Disease Models, Animal | Fibrosis - genetics | Fibrosis - chemically induced | Fibrosis - enzymology | Signal Transduction | Scleroderma, Systemic - genetics | Poly (ADP-Ribose) Polymerase-1 - metabolism | DNA Methylation - genetics | Down-Regulation - genetics | Scleroderma, Systemic - enzymology | Animals | Aged | Mice | Skin Diseases - enzymology | Transforming Growth Factor beta - metabolism | Immunohistochemistry | Smad protein | Chromatin | Immunoprecipitation | Disease | Transcription | Transforming growth factor | DNA damage | Hydroxyproline | Poly(ADP-ribose) | Smad3 protein | Arthritis | Sclerosis | Bleomycin | Ribose | Rodents | DNA methylation | Fibroblasts | Scleroderma | Growth factors | Deoxyribonucleic acid--DNA | Poly(ADP-ribose) polymerase | Gene expression | Poly(ADP-ribose) Polymerase 1 | Systemic sclerosis | Collagen | Fibrosis | Epigenetics | Skin | Methylation | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2006, Volume 103, Issue 25, pp. 9685 - 9690
Journal Article
Hypertension, ISSN 0194-911X, 11/2018, Volume 72, Issue 5, pp. 1087 - 1089
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 511, Issue 3, pp. 531 - 535
Liver regeneration is an orchestrated cellular response and the mechanisms underlying it have been extensively studied using the partial hepatectomy (PHx)... 
Hepatocyte proliferation | Poly (ADP-Ribose) Polymerase-1 | Liver regeneration | Cell cycle | ADP-RIBOSE POLYMERASE-1 | REPAIR | INHIBITION | BIOPHYSICS | PARP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 1 - 16
Journal Article
Analytical Chemistry, ISSN 0003-2700, 09/2019, Volume 91, Issue 17, pp. 11038 - 11044
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9851 - 9856
Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition... 
B lymphocytes | Homologous recombination | Cell lines | HeLa cells | Small interfering RNA | Immunoblotting | CHO cells | Hyperthermia | Cells | Tumors | Double-strand break | Anti-cancer treatment | RAD51 | POLY(ADP-RIBOSE) POLYMERASE | NUDE-MICE | STRAND BREAK REPAIR | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | RADIATION | CHO CELLS | double-strand break | HUMAN-MELANOMA | anti-cancer treatment | PHASE-I | SISTER-CHROMATID EXCHANGES | THERMAL RADIOSENSITIZATION | Embryonic Stem Cells - metabolism | Humans | Transplantation, Heterologous | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | RNA Interference | Embryonic Stem Cells - radiation effects | Neoplasms, Experimental - genetics | Recombination, Genetic - genetics | Female | Cell Line | Cells, Cultured | Rats | Hot Temperature | DNA-Binding Proteins - genetics | Lactams, Macrocyclic - pharmacology | Piperazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | Embryonic Stem Cells - drug effects | Tumor Burden - drug effects | Mice, Nude | DNA Repair | Cell Line, Tumor | Mice | Recombination, Genetic - radiation effects | HeLa Cells | Neoplasms, Experimental - metabolism | Quinazolines - pharmacology | BRCA2 Protein - genetics | Recombination, Genetic - drug effects | BRCA mutations | Proteolysis | Cancer cells | Genetic aspects | Research | Genetic recombination | Health aspects | Fever | Cancer | Proteins | Medical treatment | DNA repair | Index Medicus | BRCA2 protein | poly(ADP-ribose) polymerase 1 | BRCA1 protein | homologous recombination | Tumor cells | Heat shock proteins | Lethality | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2015, Volume 290, Issue 23, pp. 14493 - 14503
Journal Article