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Journal of Biological Chemistry, ISSN 0021-9258, 10/2002, Volume 277, Issue 42, pp. 39594 - 39598
Huntington's disease (HD) is caused by a polyglutamine expansion in the amino-terminal region of huntingtin. Mutant huntingtin is proteolytically cleaved by... 
polyglutamine
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2002, Volume 277, Issue 8, pp. 6703 - 6707
We reported previously that normal Huntingtin is associated with epidermal growth factor receptor (EGF) signaling complex (Liu, Y. F., Deth, C. R., and Devys,... 
polyglutamine
Journal Article
NATURE REVIEWS NEUROSCIENCE, ISSN 1471-003X, 06/2010, Volume 11, Issue 6, pp. 436 - 449
In ageing populations, neurodegenerative diseases increase in prevalence, exacting an enormous toll on individuals and their communities. Multiple... 
EXPANDED POLYGLUTAMINE | TRANSGENIC MOUSE | ALPHA-SYNUCLEIN TOXICITY | MUTANT HUNTINGTIN | ENDOPLASMIC-RETICULUM STRESS | PRPSC-LIKE CONFORMATION | POLYGLUTAMINE AGGREGATION | HUNTINGTONS-DISEASE | NEUROSCIENCES | PARKINSONS-DISEASE | CELLULAR TOXICITY
Journal Article
by Zhou, H and Li, S and Li, X
Journal of Biological Chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 51, pp. 48417 - 48424
Polyglutamine protein aggregation is associated with eight inherited neurodegenerative disorders. In Huntington's disease, N-terminal fragments of mutant... 
polyglutamine
Journal Article
Nature, ISSN 0028-0836, 10/2001, Volume 413, Issue 6857, pp. 691 - 694
Close to the start of the huntingtin gene lies a repetitive sequence of nucleotides, CAGCAGCAG..., that is potentially deadly. This sequence codes for a... 
polyglutamine
Journal Article
Trends in Neurosciences, ISSN 0166-2236, 11/2001, Volume 24, Issue 11, pp. S32 - S38
Huntington's disease (HD) is one of eight progressive neurodegenerative disorders in which the underlying mutation is a CAG expansion encoding a polyglutamine... 
polyglutamine
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 08/2001, Volume 10, Issue 17, pp. 1829 - 1845
Huntington's disease (HD) is one of 10 known diseases caused by a (CAG) sub(n) trinucleotide repeat expansion that is translated into an abnormally long... 
polyglutamine
Journal Article
Brain Research, ISSN 0006-8993, 10/2018, Volume 1697, pp. 21 - 33
Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by progressive movement disorders and cognitive deficits, which is caused by a... 
Intravenous immunoglobulin | Huntingtin protein | Huntington’s disease | Polyglutamine
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2001, Volume 7, Issue 5, pp. 528 - 530
The mutant proteins that cause polyglutamine disease bind CREB-binding protein (CBP), a key transcriptional coactivator for neuronal survival factors. This... 
polyglutamine
Journal Article
Cell, ISSN 0092-8674, 5/2018, Volume 173, Issue 4, pp. 989 - 1002.e13
Huntington’s disease (HD) is characterized by the preferential loss of the medium spiny neurons in the striatum. Using CRISPR-Cas9 and somatic nuclear transfer... 
neurodegeneration | large animal | polyglutamine | Knock-in
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2001, Volume 7, Issue 4, pp. 419 - 423
Polyglutamine diseases comprise a class of familial neurodegenerative disorders caused by expression of proteins containing expanded polyglutamine tracts.... 
polyglutamine
Journal Article
PLOS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0145333
Huntington’s disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular... 
Huntingtons disease | Biotechnology | Bortezomib | Polyglutamine | Peptides | Huntingtin | Amino acids | Pharmacology | Kinases | Proteasome inhibitors | Proteins | Medicine | Studies | Signal transduction | Reduction | Neurodegeneration | MicroRNAs | Cell lines | Cell cycle | Neostriatum | Cleavage | Trinucleotide repeat diseases | Apoptosis
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 04/2018, Volume 465, Issue C, pp. 113 - 121
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 08/2001, Volume 65, Issue 4, pp. 289 - 297
Huntington's disease (HD) is a neurodegenerative disorder characterized by the expansion of CAG repeats in exon 1 of the HD gene. To clarify the instability of... 
polyglutamine
Journal Article