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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6150, pp. 1089 - 1094
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12354 - 12359
Journal Article
Biochemistry, ISSN 0006-2960, 12/2014, Volume 53, Issue 49, pp. 7854 - 7865
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and... 
STREPTOMYCES-PLATENSIS | GENE-CLUSTER | CYTOCHROME-P450 ENZYMES | CELL-MIGRATION INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | TUMOR-METASTASIS | ANTIFUNGAL ANTIBIOTICS | TRANSFORMED NIH/3T3 CELLS | PHOSPHOPANTETHEINYL TRANSFERASE | POTENT INHIBITORS | Multigene Family | Macrolides - isolation & purification | Antibiotics, Antineoplastic - pharmacology | Stereoisomerism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Polyketides - chemistry | Antibiotics, Antineoplastic - isolation & purification | Structure-Activity Relationship | Polyketides - metabolism | Polyketide Synthases - metabolism | Antibiotics, Antineoplastic - chemistry | Macrolides - chemistry | Base Sequence | Drug Design | Protein Engineering | Macrolides - pharmacology | Molecular Structure | Piperidones - isolation & purification | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Cell Survival - drug effects | Polyketide Synthases - antagonists & inhibitors | Streptomyces - genetics | Bacterial Proteins - genetics | Gene Silencing | Antibiotics, Antineoplastic - biosynthesis | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Macrolides - metabolism | Piperidones - pharmacology | Neoplasms - drug therapy | Piperidones - chemistry | Polyketide Synthases - chemistry | Bioreactors | Models, Biological | Mutant Proteins - chemistry | Polyketides - isolation & purification | Cell Line, Tumor | Bacterial Proteins - metabolism | Streptomyces - enzymology | Piperidones - metabolism | Polyketide Synthases - genetics | Polyketides - pharmacology | Streptomyces | Physiological aspects | Biosynthesis | Analysis
Journal Article
Molecular Plant Pathology, ISSN 1464-6722, 08/2011, Volume 12, Issue 6, pp. 564 - 579
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2017, Volume 139, Issue 23, pp. 7913 - 7920
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 12/2014, Volume 53, Issue 49, pp. 13553 - 13557
Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post‐PKS modifications result in a significantly elevated level of... 
total synthesis | post‐polyketide synthase modifications | biosynthesis | polyketide macrolides | spinosyns | Spinosyns |