X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (3298) 3298
Publication (583) 583
Book Review (297) 297
Book Chapter (29) 29
Conference Proceeding (16) 16
Dissertation (9) 9
Government Document (1) 1
Reference (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (2961) 2961
poly polymerase-1 (2598) 2598
humans (2154) 2154
animals (1673) 1673
poly polymerases - metabolism (1448) 1448
mice (1052) 1052
apoptosis (989) 989
biochemistry & molecular biology (824) 824
poly polymerase (722) 722
poly polymerases - genetics (699) 699
male (655) 655
cell biology (647) 647
female (633) 633
cell line, tumor (607) 607
dna damage (607) 607
oncology (582) 582
dna repair (560) 560
apoptosis - drug effects (532) 532
cancer (529) 529
poly polymerase inhibitors (514) 514
proteins (471) 471
oxidative stress (462) 462
activation (452) 452
parp-1 (432) 432
poly polymerase-1 - metabolism (377) 377
rats (373) 373
article (360) 360
cell line (359) 359
dna (343) 343
expression (328) 328
dna-damage (317) 317
cell-death (303) 303
cells (301) 301
cells, cultured (299) 299
pharmacology & pharmacy (282) 282
analysis (280) 280
poly polymerase 1 (279) 279
neurosciences (273) 273
research (273) 273
gene expression (266) 266
cell death (265) 265
deoxyribonucleic acid--dna (263) 263
mice, knockout (262) 262
enzyme inhibitors - pharmacology (260) 260
enzymes (258) 258
caspase 3 - metabolism (256) 256
inhibition (252) 252
cell survival - drug effects (249) 249
monosaccharides (240) 240
signal transduction (238) 238
sugars (238) 238
antineoplastic agents - pharmacology (237) 237
parp (237) 237
repair (234) 234
phosphorylation (226) 226
nf-kappa-b (222) 222
gene-expression (220) 220
in-vitro (217) 217
poly polymerase-1 - genetics (209) 209
multidisciplinary sciences (204) 204
toxicology (203) 203
ribose (202) 202
inflammation (201) 201
poly (200) 200
middle aged (199) 199
death (197) 197
genetic aspects (195) 195
poly polymerases (195) 195
poly polymerases - physiology (195) 195
protein binding (193) 193
caspases - metabolism (191) 191
cell proliferation - drug effects (191) 191
blotting, western (190) 190
genetics & heredity (187) 187
mice, inbred c57bl (186) 186
tumors (185) 185
transcription (183) 183
protein (182) 182
dna-binding proteins - metabolism (181) 181
mutation (180) 180
enzyme activation (179) 179
hela cells (179) 179
research article (179) 179
health aspects (178) 178
parp1 (176) 176
reactive oxygen species - metabolism (175) 175
homologous recombination (174) 174
physiological aspects (173) 173
polymerase (173) 173
damage (169) 169
double-strand breaks (169) 169
disease models, animal (167) 167
chromatin (166) 166
poly adenosine diphosphate ribose - metabolism (166) 166
aged (164) 164
rodents (162) 162
breast cancer (159) 159
dose-response relationship, drug (158) 158
biology (155) 155
apoptosis - physiology (154) 154
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3251) 3251
Chinese (33) 33
Russian (8) 8
French (7) 7
German (5) 5
Japanese (3) 3
Ukrainian (3) 3
Korean (2) 2
Polish (2) 2
Hungarian (1) 1
Portuguese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7635, pp. 87 - 91
XRCC1 is a molecular scaffold protein that assembles multiprotein complexes involved in DNA single-strand break repair(1,2). Here we show that biallelic... 
POLY(ADP-RIBOSE) POLYMERASE | CELLS | RATES | STRAND BREAK REPAIR | SPINOCEREBELLAR ATAXIA | REPLICATION | BASE EXCISION-REPAIR | GENE | DNA | MULTIDISCIPLINARY SCIENCES | DISEASE | Chromatin - metabolism | Humans | Adenosine Diphosphate Ribose - metabolism | DNA Repair Enzymes - genetics | Male | DNA Repair - genetics | DNA-Binding Proteins - deficiency | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | Apraxias - congenital | Apraxias - genetics | DNA Repair Enzymes - metabolism | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Ataxia - genetics | Cogan Syndrome - genetics | Cerebellum - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Poly (ADP-Ribose) Polymerase-1 - metabolism | Cerebellar Ataxia - pathology | DNA-Binding Proteins - genetics | Interneurons - pathology | Cerebellum - pathology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Phenotype | Animals | Cerebellar Ataxia - genetics | Interneurons - metabolism | Pedigree | Axons - pathology | Alleles | Mice | Mutation | X-ray Repair Cross Complementing Protein 1 | Poly (ADP-Ribose) Polymerase-1 - genetics | Genetic aspects | Gene mutations | Health aspects | Cerebellar ataxia | Proteins | Studies | Genotype & phenotype | Disease | Fibroblasts | Ataxia | Peripheral neuropathy | Patients | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 2, pp. 260 - 271
Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by PARP family members, such as PARP-1. Although PARylation has... 
C/EBPβ | adipogenesis | transcription | PARP inhibitor | poly(ADP-ribose) | PARP-1 | DNA binding | gene expression | PARylation | 3T3-L1 PREADIPOCYTES | CHROMATIN-STRUCTURE | GENOMIC ANALYSES | POLY(ADP-RIBOSE) POLYMERASES | ADIPOCYTE FUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | ADP-RIBOSYLATION | DIFFERENTIATION | REGULATORY DOMAIN | BINDING | CELL BIOLOGY | NIH 3T3 Cells | Transcription, Genetic - drug effects | Adipogenesis - drug effects | Transcriptional Activation | Adipocytes - enzymology | Male | Adipocytes - drug effects | Transfection | RNA Interference | Time Factors | Poly (ADP-Ribose) Polymerase-1 - deficiency | Protein Domains | Binding Sites | Signal Transduction | CCAAT-Enhancer-Binding Protein-beta - genetics | Mice, Inbred C57BL | Embryonic Stem Cells - enzymology | Genotype | Poly (ADP-Ribose) Polymerase-1 - metabolism | DNA - metabolism | 3T3-L1 Cells | CCAAT-Enhancer-Binding Protein-beta - metabolism | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Mice, Knockout | DNA - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Phenotype | Poly Adenosine Diphosphate Ribose - metabolism | Animals | Embryonic Stem Cells - drug effects | Protein Binding | Mice | Protein Processing, Post-Translational | Mutation | Poly (ADP-Ribose) Polymerase-1 - genetics | Index Medicus | 3T3 cells | Transcription | Poly(ADP-ribose) | Stromal vascular fraction (SVF) | Gene expression | NIH | 3T3-L1 cells | Adipogenesis | EBPβ
Journal Article
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, pp. 12425 - 12425
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2011, Volume 407, Issue 1, pp. 149 - 170
Poly(ADP-ribose)polymerase-1 (PARP-1) is a highly abundant chromatin-associated enzyme present in all higher eukaryotic cell nuclei, where it plays key roles... 
solution structure | DNA single-strand breaks | poly(ADP ribose)polymerase-1 | zinc finger | DNA repair | poly(ADP ribose) polymerase-1 | CHROMATIN-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | IDENTIFICATION | HUMAN POLY(ADP-RIBOSE) POLYMERASE | REPAIR | ENZYME ACTIVATION | ADP-RIBOSYLATION | LIGASE-III | DIPOLAR COUPLINGS | PROTEINS | Chromatin - metabolism | Zinc Fingers | Magnetic Resonance Spectroscopy | Humans | DNA - metabolism | Mutation - genetics | DNA Breaks, Single-Stranded | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Protein Binding | Electrophoretic Mobility Shift Assay | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerases - chemistry | Ligases | DNA | Genetic research | Nuclear magnetic resonance spectroscopy | Disease susceptibility | Zinc finger proteins | DNA binding proteins | Sugars | Monosaccharides | Index Medicus | F1, finger 1 | BER, base excision repair | EMSA, electromobility shift assay | RDC, residual dipolar coupling | BRCT, breast cancer susceptibility protein C-terminal domain | NOE, nuclear Overhauser effect | PARP-1, poly(ADP-ribose)polymerase-1 | DL3, DNA ligase IIIα | ssDNA, single-stranded DNA | HSQC, heteronuclear single-quantum coherence | F2, finger 2 | NOESY, NOE spectroscopy | SSBR, single-strand break repair | PAR, poly(ADP-ribose) | SV-AUC, sedimentation velocity analytical ultracentrifugation
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6331, pp. 1312 - 1317
Journal Article
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2016, Volume 65, Issue 4, pp. 1161 - 1169
Objective Chronic nonhealing wounds are a major health problem for patients in the United States and worldwide. Diabetes and ischemia are two major risk... 
Surgery | SURGERY | CRITICAL LIMB ISCHEMIA | ENDOTHELIAL PROGENITOR CELLS | POLY(ADP-RIBOSE) POLYMERASE | CONTROLLED TRIAL | THERAPY | MOBILIZATION | DOUBLE-BLIND | FOOT ULCERS | PERIPHERAL VASCULAR DISEASE | NEOVASCULARIZATION | HYPEROXIA | Neovascularization, Physiologic - drug effects | Antigens, CD34 - metabolism | Diabetes Mellitus, Experimental - enzymology | Humans | Ischemia - enzymology | Diabetic Angiopathies - etiology | Male | Skin Ulcer - etiology | Endothelial Progenitor Cells - enzymology | Cell Hypoxia | Diabetic Angiopathies - pathology | Time Factors | Ischemia - complications | Poly (ADP-Ribose) Polymerase-1 - deficiency | Diabetic Angiopathies - enzymology | Diabetes Mellitus, Experimental - complications | Angiogenesis Inducing Agents - pharmacology | Nitric Oxide Synthase Type III - metabolism | Skin Ulcer - enzymology | Wound Healing - drug effects | Ischemia - pathology | Diabetes Mellitus, Experimental - physiopathology | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Progenitor Cells - drug effects | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diabetic Angiopathies - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Mice, Knockout | Cell Movement - drug effects | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Skin Ulcer - pathology | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Skin Ulcer - drug therapy | AC133 Antigen - metabolism | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Medical colleges | Care and treatment | Wound healing | Wounds and injuries | Sugars | Monosaccharides | Endothelial growth factors | Analysis | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2018, Volume 33, Issue 6, pp. 1078 - 1093.e12
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 285 - 289
The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP-ribose) polymerase (PARP) has spurred the development of cancer... 
RNASE H2 | CELLS | REPLICATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DNA-DAMAGE | ANTIANDROGEN RESISTANCE | LINEAGE PLASTICITY | GENES | TRANSCRIPTION | TOPOISOMERASE-I | Humans | Genome - genetics | Male | Synthetic Lethal Mutations | DNA Repair - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Ribonucleotides - genetics | Neoplasms - genetics | Poly (ADP-Ribose) Polymerase-1 - deficiency | Female | Genes, BRCA1 | BRCA1 Protein - deficiency | Prostatic Neoplasms - drug therapy | Ribonuclease H - genetics | DNA Damage - drug effects | Cell Line | Prostatic Neoplasms - pathology | DNA Topoisomerases, Type I - metabolism | Ribonuclease H - deficiency | Neoplasms - enzymology | DNA Replication | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Gene Editing | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Animals | CRISPR-Cas Systems | Prostatic Neoplasms - enzymology | Mice | HeLa Cells | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Neoplasms - pathology | Poly (ADP-Ribose) Polymerase-1 - genetics | Ribonuclease H - metabolism | DNA polymerases | Physiological aspects | Ribonucleotides | Genetic aspects | Ionizing radiation | DNA replication | Genes | Genomics | Development and progression | Ribonuclease | Health aspects | Prostate cancer | Sugars | Monosaccharides | Toxicity | Leukemia | Homologous recombination | DNA damage | Poly(ADP-ribose) | Cytotoxicity | Homology | Genomes | Kinases | ADP | Metastases | Ribonuclease H2 | Proteins | Dwarfism | Genotype & phenotype | Clonal deletion | Ribose | Cell cycle | Deletion | Inhibition | Lesions | Repair | Deoxyribonucleic acid--DNA | Adducts | BRCA2 protein | CRISPR | Enzymes | Chronic lymphatic leukemia | BRCA1 protein | Anemia | Hypersensitivity | Poly(ADP-ribose) polymerase | Breast cancer | Screens | Substrates | Polymerase | DNA biosynthesis | Poly(ADP-ribose) Polymerase 1 | Trapping | Inhibitors | Mutation | DNA adducts | Prostate | Cancer | Index Medicus
Journal Article