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science & technology (34) 34
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1. Full Text Polymerase epsilon mutations and concomitant Ī²2-microglobulin mutations in cancer
by Voutsadakis, Ioannis A
Gene, ISSN 0378-1119, 03/2018, Volume 647, pp. 31 - 38
Polymerase epsilon | cBioportal | Exonuclease domain | Neo-antigens | Genomic | Index Medicus
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2. Full Text Checkpoint inhibitors in endometrial cancer: Preclinical rationale and clinical activity
by Mittica, Gloria and Ghisoni, Eleonora and Giannone, Gaia and Aglietta, Massimo and Genta, Sofia and Valabrega, Giorgio
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 52, pp. 90532 - 90544
Microsatellite instability (MSI) | Endometrial cancer | Tumor infiltrating lymphocytes (TILs) | Immunotherapy | Polymerase epsilon (POLE)-ultra-mutated | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology
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3. Full Text POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
by van Gool, Inge C and Eggink, Florine A and Freeman-Mills, Luke and Stelloo, Ellen and Marchi, Emanuele and de Bruyn, Marco and Palles, Claire and Nout, Remi A and de Kroon, Cor D and Osse, Elisabeth M and Klenerman, Paul and Creutzberg, Carien L and Tomlinson, Ian P. M and Smit, Vincent T. H. B. M and Nijman, Hans W and Bosse, Tjalling and Church, David N
Clinical cancer research, ISSN 1078-0432, 07/2015, Volume 21, Issue 14, pp. 3347 - 3355
SURVIVAL | RECTAL-CANCER | EXONUCLEASE DOMAIN MUTATIONS | MICROSATELLITE INSTABILITY | COLORECTAL-CANCER | RANDOMIZED-TRIAL | DNA-POLYMERASE EPSILON | CARCINOMA | EXOME ANALYSIS REVEALS | T-CELLS | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Humans | DNA Polymerase II - immunology | Poly-ADP-Ribose Binding Proteins | Endometrial Neoplasms - immunology | Endometrial Neoplasms - genetics | DNA Mutational Analysis | Fluorescent Antibody Technique | Polymerase Chain Reaction | Female | Mutation | DNA Polymerase II - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
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4. Full Text Molecular pathological classification of colorectal cancer
by MĆ¼ller, Mike F and Ibrahim, Ashraf E. K and Arends, Mark J
Virchows Archiv : an international journal of pathology, ISSN 0945-6317, 8/2016, Volume 469, Issue 2, pp. 125 - 134
Somatic copy number alterations | Colorectal | Microsatellite instability | Chromosomal instability | Defective mismatch repair | The Cancer Genome Atlas | Pathology | Ultramutant | Polymerase epsilon | Medicine & Public Health | Serrated pathway | Hypermutant | Mutation | Consensus molecular subtypes | Cancer | Life Sciences & Biomedicine | Science & Technology | Microsatellite Instability | Colorectal Neoplasms - immunology | Colorectal Neoplasms - genetics | Humans | ras Proteins - metabolism | Colorectal Neoplasms - pathology | Mutation - genetics | Pathology, Molecular | Gene Expression Regulation, Neoplastic - genetics | Tumor proteins | Analysis | Genomics | Stem cells | Colorectal cancer | Index Medicus | Review and s
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5. Full Text Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine
by Nebot-Bral, Laetitia and Brandao, David and Verlingue, Loic and Rouleau, Etienne and Caron, Olivier and Despras, Emmanuelle and El-Dakdouki, Yolla and Champiat, StƩphane and Aoufouchi, Said and Leary, Alexandra and Marabelle, AurƩlien and Malka, David and Chaput, Nathalie and Kannouche, Patricia L
European journal of cancer (1990), ISSN 0959-8049, 10/2017, Volume 84, pp. 290 - 303
Endometrial cancer | Immune checkpoint inhibitor | DNA polymerase epsilon | Immunotherapy | Colorectal cancer | Microsatellite instability | Immune signature | DNA mismatch repair | Neoantigen | Life Sciences & Biomedicine | Oncology | Science & Technology | Predictive Value of Tests | Immunotherapy - methods | Microsatellite Instability | Tumor Escape | DNA Polymerase III - genetics | Humans | Tumor Microenvironment | DNA Polymerase II - metabolism | Molecular Targeted Therapy | Poly-ADP-Ribose Binding Proteins | Neoplasms - therapy | Neoplasms - genetics | DNA Mutational Analysis | DNA Mismatch Repair | DNA Polymerase II - genetics | Antigens, Neoplasm - genetics | Genetic Predisposition to Disease | Antigens, Neoplasm - immunology | Phenotype | Neoplasms - immunology | Biomarkers, Tumor - genetics | Mutation | DNA Polymerase III - metabolism | Neoplasms - pathology | Biomarkers, Tumor - immunology | Precision Medicine - methods | Biological products | Drug approval | Tumors | Immune response | Cell death | Tumor antigens | DNA polymerase | Genomes | Metastasis | Patients | Molecular chains | Metastases | Medicine | Exonuclease | Pembrolizumab | Immune checkpoint | Mismatch repair | Catalysis | Deoxyribonucleic acid--DNA | DNA-directed DNA polymerase | Cancer | Apoptosis | Immune system | Index Medicus
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6. Full Text Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles
by Siamishi, Iliana and Iwanami, Norimasa and Clapes, Thomas and Trompouki, Eirini and Oā€™Meara, Connor P and Boehm, Thomas
Cell reports (Cambridge), ISSN 2211-1247, 06/2020, Volume 31, Issue 11, pp. 107756 - 107756
B cell | lymphopoiesis | non-replicative function | DNA polymerase epsilon | T cell | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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7. Full Text Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
by Bellelli, Roberto and Youds, Jillian and Borel, Valerie and Svendsen, Jennifer and Pavicic-Kaltenbrunner, Visnja and Boulton, Simon J
Cell reports (Cambridge), ISSN 2211-1247, 05/2020, Volume 31, Issue 8, pp. 107675 - 107675
genome stability | RTEL1 | DNA replication | origin activation | DNA polymerase epsilon | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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8. Full Text Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
by Erson-Omay, E. Zeynep and CąŹ‡layan, Ahmet Okay and Schultz, Nikolaus and Weinhold, Nils and Omay, S. BĆ¼lent and Ɩzduman, Koray and Kƶksal, Yavuz and Li, Jie and Serin Harmancl, Akdes and Clark, Victoria and CarriĆ³n-Grant, Geneive and Baranoski, Jacob and CąŹ‡lar, Caner and Barak, Tanyeri and Coşkun, SĆ¼leyman and Baran, BurƧin and Kƶse, DoŹ‡an and Sun, Jia and BaklrcloŹ‡lu, Mehmet and Moliterno GĆ¼nel, Jennifer and Pamir, M. Necmettin and Mishra-Gorur, Ketu and Bilguvar, Kaya and Yasuno, Katsuhito and Vortmeyer, Alexander and Huttner, Anita J and Sander, Chris and GĆ¼nel, Murat
Neuro-oncology (Charlottesville, Va.), ISSN 1522-8517, 10/2015, Volume 17, Issue 10, pp. 1356 - 1364
ultramutated tumor | Oncology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prognosis | Glioma - classification | Glioma - diagnosis | Brain Neoplasms - diagnosis | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Child, Preschool | DNA Copy Number Variations | Glioma - genetics | Young Adult | Disease-Free Survival | Poly-ADP-Ribose Binding Proteins | Phenotype | Brain Neoplasms - classification | DNA Mutational Analysis | Glioma - pathology | Adult | Mutation | Child | DNA Polymerase II - genetics | Index Medicus | germline MSH6 mutation | better prognosis | glioblastoma | polymerase epsilon | Basic and Translational Investigations
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9. Full Text DNA polymerase epsilon is required for heterochromatin maintenance in Arabidopsis
by Bourguet, Pierre and LĆ³pez-GonzĆ”lez, Leticia and GĆ³mez-Zambrano, Ɓngeles and PĆ©lissier, Thierry and Hesketh, Amy and Potok, Magdalena E and Pouch-PĆ©lissier, Marie-NoĆ«lle and Perez, Magali and Da Ines, Olivier and Latrasse, David and White, Charles I and Jacobsen, Steven E and Benhamed, Moussa and Mathieu, Olivier
Genome Biology, ISSN 1474-7596, 12/2020, Volume 21, Issue 1, pp. 1 - 283
DNA methylation | Heterochromatin | Silencing | DNA polymerase epsilon | Replication stress | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Chromatin | Genes | Genomes | DNA biosynthesis | Proteins | Gene silencing | Lysine | Euchromatin | Cell cycle | Histones | Epigenetics | Mutation | Deoxyribonucleic acid--DNA | Deficient mutant | DNA-directed DNA polymerase | Histone H3 | Structure-function relationships | Index Medicus
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10. Full Text Crystal structure of the human PolĪµ B-subunit in complex with the C-terminal domain of the catalytic subunit
by Baranovskiy, Andrey G and Gu, Jianyou and Babayeva, Nigar D and Kurinov, Igor and Pavlov, Youri I and Tahirov, Tahir H and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of biological chemistry, ISSN 0021-9258, 09/2017, Volume 292, Issue 38, pp. 15717 - 15730
Amino Acid Sequence | Catalytic Domain | Humans