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index medicus (294) 294
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male (112) 112
liver - metabolism (90) 90
rats (89) 89
liver (86) 86
organic anion transporters - genetics (79) 79
organic anion transporters - metabolism (79) 79
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pharmacokinetics (68) 68
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solute carrier organic anion transporter family member 1b1 (56) 56
expression (54) 54
anion transporting polypeptide (53) 53
polypeptide (51) 51
drug interactions (50) 50
human liver (47) 47
organic anion transporter (46) 46
biological transport (45) 45
hepatic-uptake (44) 44
rats, sprague-dawley (41) 41
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adult (39) 39
biochemistry & molecular biology (39) 39
hepatocytes - metabolism (38) 38
solute carrier organic anion transporter family member 1b3 (35) 35
metabolism (34) 34
oatp (34) 34
pravastatin (34) 34
organic anion transporters, sodium-independent - metabolism (33) 33
proteins (33) 33
abridged index medicus (32) 32
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rat (31) 31
gastroenterology & hepatology (30) 30
physiological aspects (30) 30
rodents (30) 30
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organic anion transporters, sodium-independent - genetics (28) 28
single nucleotide polymorphisms (28) 28
genotype (27) 27
kinetics (27) 27
transporter (27) 27
gene expression (26) 26
pharmacology (26) 26
area under curve (25) 25
blood-brain barrier (25) 25
carrier proteins - metabolism (25) 25
cell line (25) 25
hepatocytes (25) 25
localization (25) 25
mice (25) 25
oatp1b1 (25) 25
rat-liver (25) 25
statins (25) 25
toxicology (25) 25
biomedicine (24) 24
organic anion transporters - antagonists & inhibitors (24) 24
physiology (24) 24
liver - drug effects (23) 23
cancer (22) 22
chemistry, multidisciplinary (22) 22
rats, wistar (22) 22
xenopus laevis (22) 22
cell biology (21) 21
disposition (21) 21
dose-response relationship, drug (21) 21
pharmacogenetics (21) 21
pharmacology/toxicology (21) 21
transport (21) 21
drugs (20) 20
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pharmacy (20) 20
rna, messenger - metabolism (20) 20
slco1b1 (20) 20
cells, cultured (19) 19
drug-drug interaction (19) 19
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hydroxymethylglutaryl-coa reductase inhibitors - pharmacokinetics (19) 19
medicine, research & experimental (19) 19
middle aged (19) 19
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oatp-c (19) 19
organic anion (19) 19
polymorphism, single nucleotide (19) 19
transfection (19) 19
administration, oral (18) 18
anions (18) 18
biopolymers (18) 18
brain - metabolism (18) 18
drug-interactions (18) 18
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genetic polymorphisms (18) 18
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Journal Article
Environmental Toxicology and Pharmacology, ISSN 1382-6689, 2017, Volume 51, pp. 16 - 22
Highlights • Down-regulated Mrp2 may be the liver injury mechanism of Dioscorea bulbifera L. • Diosbulbin B is the mainly ingredient of hepatotoxicity in... 
Emergency | Dioscorea bulbifera L | Diosbulbin B | Na+-taurocholate co-transporting polypeptide | Multidrug resistance associated protein 2 | Organic anion transporting polypeptide 2 | Bile salt export pump | MECHANISM | CHINA | RATS | RHIZOME | PROTECTS | ENVIRONMENTAL SCIENCES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Na plus -taurocholate co-transporting polypeptide | PROTEIN-2 | Liver - pathology | Gene Expression - drug effects | Male | Organic Anion Transporters, Sodium-Dependent - genetics | ATP-Binding Cassette Transporters - genetics | Liver - drug effects | Heterocyclic Compounds, 4 or More Rings - toxicity | Lipid Peroxidation - drug effects | ATP-Binding Cassette Transporters - metabolism | Multidrug Resistance-Associated Proteins - genetics | Dioscorea - chemistry | Chemical and Drug Induced Liver Injury - pathology | Drugs, Chinese Herbal - isolation & purification | Chemical and Drug Induced Liver Injury - etiology | Organic Cation Transport Proteins - metabolism | Liver - metabolism | Mice, Inbred ICR | Symporters - metabolism | Heterocyclic Compounds, 4 or More Rings - isolation & purification | Drugs, Chinese Herbal - toxicity | Animals | ATP Binding Cassette Subfamily B Member 11 | Chemical and Drug Induced Liver Injury - metabolism | Symporters - genetics | Organic Cation Transport Proteins - genetics | Multidrug Resistance-Associated Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Pharmacy | Bilirubin | Drug resistance in microorganisms | Bile acids | Analysis | Liver | mRNA | Western blotting | Rodents | Protein transport | Hepatotoxicity | Injury analysis | Glutathione | Thyroid | Excretion | Liver diseases | Biochemical analysis | Oral administration | Liquid chromatography | Chromatography | Substrates | Studies | Herbal medicine | Injury prevention | Thyroid cancer | Acids | Mice | Transporter | Cancer | Bile | Index Medicus
Journal Article
Journal Article
Liver International, ISSN 1478-3223, 10/2007, Volume 27, Issue 8, pp. 1056 - 1065
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 2/2002, Volume 19, Issue 2, pp. 147 - 153
Purpose. The purpose of the present study is to examine the selectivity of various inhibitors towards the rat organic anion transporting polypeptides 1 (Oatp1:... 
Biochemistry, general | Biomedical Engineering | Biomedicine | Pharmacy | organic anion transporter | Medical Law | Oatp | Pharmacology/Toxicology | hepatic transport | Hepatic transport | Organic anion transporter | MOLECULAR CHARACTERIZATION | HEPATOCYTES | HEPATIC-UPTAKE | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | CLONING | LIVER | PHARMACOLOGY & PHARMACY | RLST-1 | EXPRESSION | POLYPEPTIDE
Journal Article
LABORATORY INVESTIGATION, ISSN 0023-6837, 04/2003, Volume 83, Issue 4, pp. 527 - 538
Transport proteins mediating the selective uptake of organic anions into human hepatocytes include the organic anion transporters SLC21A6 (also termed OATP2,... 
RAT-LIVER | MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | MEMBRANE | MULTIDRUG-RESISTANCE PROTEIN | PATHOLOGY | IDENTIFICATION | TUMORS | EPITHELIAL-CELLS | POLYPEPTIDE OATP2 | MEDICAL LABORATORY TECHNOLOGY | METASTATIC CARCINOMAS | HEPATOCYTE CANALICULAR ISOFORM
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 03/2008, Volume 25, Issue 3, p. 578
To identify the rat hepatic basolateral transporters involved in the hepatic uptake of [beta]-lactam antibiotics using nafcillin as a model [beta]-lactam... 
Beta lactam antibiotics | Caprolactam | Polypeptides | Antibacterial agents | Pharmacology | Antibiotics | Peptides | Metabolism | Liver | Rodents
Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 1/2003, Volume 38, Issue 1, pp. 108 - 109
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 05/2018, Volume 46, Issue 5, pp. 652 - 657
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2003, Volume 139, Issue 1, pp. 35 - 48
Journal Article