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1. Full Text Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)
by Hospenthal, Manuela K and Mevissen, Tycho E. T and Komander, David
Nature protocols, ISSN 1754-2189, 01/2015, Volume 10, Issue 2, pp. 349 - 361
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Ubiquitin - analysis | Ubiquitin-Specific Proteases - chemistry | Ubiquitinated Proteins - chemistry | Ubiquitination | Biochemistry - methods | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Specific Proteases - metabolism | Ubiquitinated Proteins - analysis | Blotting, Western | Medical equipment | Enzymes | Protein research | Usage | Regulation | Research | Ubiquitin-proteasome system | Observations | Physiological apparatus | Index Medicus | branched ubiquitin | mixed linkage chain | deubiquitinating enzyme | ubiquitin | polyubiquitin chain type
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2. Full Text Atypical ubiquitin chains: New molecular signals. 'Protein Modifications: Beyond the Usual Suspects' Review Series
by Ikeda, Fumiyo and Dikic, Ivan
EMBO reports, ISSN 1469-221X, 06/2008, Volume 9, Issue 6, pp. 536 - 542
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polyubiquitin - metabolism | Protein Structure, Tertiary | Models, Molecular | Protein Binding | Signal Transduction - physiology | Protein Processing, Post-Translational | Polyubiquitin - chemistry | Polyubiquitin - classification | Proteins | Molecular biology | DNA repair | Binding sites | Cell cycle | Index Medicus | atypical chain | ubiquitin-like protein | UBD | Review | signalling | ubiquitin | Ubl
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3. Full Text Polyubiquitin chains: polymeric protein signals
by Pickart, Cecile M and Fushman, David
Current opinion in chemical biology, ISSN 1367-5931, 2004, Volume 8, Issue 6, pp. 610 - 616
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Polyubiquitin - metabolism | Animals | Signal Transduction | Ubiquitin-Protein Ligases - metabolism | Protein Binding | Protein Conformation | Lysine - metabolism | Dimerization | Polyubiquitin - chemistry | Ubiquitin | Polymers | Index Medicus
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4. Full Text Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes?
by Nathan, James A and Tae Kim, Hyoung and Ting, Lily and Gygi, Steven P and Goldberg, Alfred L
The EMBO journal, ISSN 0261-4189, 02/2013, Volume 32, Issue 4, pp. 552 - 565
lysine‐48 | proteasome | lysine‐63 | polyubiquitin | ubiquitin binding protein | lysine-63 | lysine-48 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polyubiquitin - metabolism | Rabbits | Endosomes - genetics | Lysosomes - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Rats | Endosomes - metabolism | Polyubiquitin - genetics | Proteasome Endopeptidase Complex - genetics | Animals | Lysosomes - metabolism | Ubiquitinated Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitinated Proteins - metabolism | Proteins | Amino acids | Cellular biology | Molecular biology | Index Medicus
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5. Full Text Total Chemical Synthesis of Di‐ubiquitin Chains
by Kumar, K. S. Ajish and Spasser, Liat and Erlich, Lesly A and Bavikar, Sudhir N and Brik, Ashraf
Angewandte Chemie (International ed.), ISSN 1433-7851, 11/2010, Volume 49, Issue 48, pp. 9126 - 9131
peptides | ligation | proteins | synthetic methods | ubiquitin | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Models, Molecular | Molecular Sequence Data | Amino Acid Sequence | Polyubiquitin - chemical synthesis | Humans | Polyubiquitin - chemistry | Index Medicus
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6. Full Text Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
by Licchesi, Julien D F and Wilkinson, Keith D and Odenwaelder, Peter and Barford, David and Reyes-Turcu, Francisca and Komander, David
EMBO reports, ISSN 1469-221X, 05/2009, Volume 10, Issue 5, pp. 466 - 473
TAK1/IKK/NEMO/NF‐κB | ubiquitin binding domain | NF‐κB signalling | ubiquitin linkage | deubiquitinase | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proteins | Signal transduction | Cellular biology | Molecular biology | Binding sites | Index Medicus | NF-κB | TAK1 | NF-κB signalling | IKK | NEMO | Scientific Report
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7. Full Text Direct activation of protein kinases by unanchored polyubiquitin chains
by Xia, Zong-Ping and Sun, Lijun and Chen, Xiang and Pineda, Gabriel and Jiang, Xiaomo and Adhikari, Anirban and Zeng, Wenwen and Chen, Zhijian J
Nature (London), ISSN 0028-0836, 09/2009, Volume 461, Issue 7260, pp. 114 - 119
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Signal transduction | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Polyubiquitin - metabolism | Cell Line | DEAD Box Protein 58 | Interleukin-1beta - pharmacology | Phosphorylation | Tumor Suppressor Proteins - metabolism | Deubiquitinating Enzyme CYLD | Polyubiquitin - biosynthesis | Humans | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Ubiquitination | I-kappa B Kinase - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Lysine - metabolism | HeLa Cells | Ubiquitin-Conjugating Enzymes | Adaptor Proteins, Signal Transducing - metabolism | DEAD-box RNA Helicases - metabolism | Ubiquitin | Physiological aspects | Genetic aspects | Research | Protein kinases | Proteins | Enzymes | Kinases | Cells | Index Medicus
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8. Full Text A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7
by Verhelst, Kelly and Carpentier, Isabelle and Kreike, Marja and Meloni, Laura and Verstrepen, Lynn and Kensche, Tobias and Dikic, Ivan and Beyaert, Rudi
The EMBO journal, ISSN 0261-4189, 10/2012, Volume 31, Issue 19, pp. 3845 - 3855
TNFAIP3 | NF‐κB | zinc finger | ubiquitin | A20 | NF-kB | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polyubiquitin - metabolism | Humans | NF-kappa B - metabolism | Nuclear Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | Tumor Necrosis Factor-alpha - pharmacology | I-kappa B Kinase - metabolism | Signal Transduction - drug effects | HEK293 Cells | Signal Transduction - physiology | Tumor Necrosis Factor alpha-Induced Protein 3 | Zinc Fingers - physiology | Protein Binding - physiology | Index Medicus | NF-κB
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9. Full Text A single MIU motif of MINDY‐1 recognizes K48‐linked polyubiquitin chains
by Kristariyanto, Yosua Adi and Abdul Rehman, Syed Arif and Weidlich, Simone and Knebel, Axel and Kulathu, Yogesh
EMBO reports, ISSN 1469-221X, 03/2017, Volume 18, Issue 3, pp. 392 - 402
ubiquitin binding domain | motif interacting with ubiquitin | polyubiquitin | MINDY deubiquitinase | ubiquitin signaling | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Polyubiquitin - metabolism | Amino Acid Sequence | Models, Molecular | Tandem Repeat Sequences | Amino Acid Motifs | Ubiquitination | Models, Biological | Conserved Sequence | Protein Binding | Ubiquitin Thiolesterase - metabolism | Protein Conformation | Protein Interaction Domains and Motifs | Polyubiquitin - chemistry | Ubiquitin Thiolesterase - chemistry | Enzymes | Cellular biology | Binding sites | Crystal structure | Index Medicus | Signal Transduction | Post-translational Modifications, Proteolysis & Proteomics | Structural Biology | Scientific Report
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10. Full Text The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling
by Ohtake, Fumiaki and Saeki, Yasushi and Ishido, Satoshi and Kanno, Jun and Tanaka, Keiji
Molecular cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 251 - 266
NF-κB | CYLD | AQUA | proteomics | Lys63 | inflammation | TRAF6 | HUWE1 | Lys48 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Adaptor Proteins, Signal Transducing - chemistry | Interleukin-1beta - pharmacology | Deubiquitinating Enzyme CYLD | Humans | Ubiquitin - metabolism | Substrate Specificity | NF-kappa B - metabolism | NF-kappa B - chemistry | Polyubiquitin - genetics | Ubiquitination | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Osteoblasts - cytology | TNF Receptor-Associated Factor 6 - genetics | Binding Sites | Polyubiquitin - chemistry | Polyubiquitin - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Tumor Suppressor Proteins - metabolism | Signal Transduction | Osteoblasts - drug effects | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Alignment | NF-kappa B - genetics | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
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