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1. Full Text Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)
by Hospenthal, Manuela K and Mevissen, Tycho E. T and Komander, David
Nature Protocols, ISSN 1754-2189, 01/2015, Volume 10, Issue 2, pp. 349 - 361
Protein ubiquitination is a versatile protein modification that regulates virtually all cellular processes. This versatility originates from polyubiquitin... 
LOCALIZATION | ACTIVATION | COMPLEX | POLYUBIQUITIN | RECOGNITION | MECHANISM | PROTEIN-DEGRADATION | BIOCHEMICAL RESEARCH METHODS | CROSS-REACTIVITY | BINDING | REVEALS | Ubiquitin - analysis | Ubiquitin-Specific Proteases - chemistry | Ubiquitinated Proteins - chemistry | Ubiquitination | Biochemistry - methods | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Specific Proteases - metabolism | Ubiquitinated Proteins - analysis | Blotting, Western | Medical equipment | Enzymes | Protein research | Usage | Regulation | Research | Ubiquitin-proteasome system | Observations | Physiological apparatus | branched ubiquitin | mixed linkage chain | deubiquitinating enzyme | ubiquitin | polyubiquitin chain type
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2. Full Text Atypical ubiquitin chains: New molecular signals. 'Protein Modifications: Beyond the Usual Suspects' Review Series
by Ikeda, Fumiyo and Dikic, Ivan
EMBO Reports, ISSN 1469-221X, 06/2008, Volume 9, Issue 6, pp. 536 - 542
Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including gene transcription, cell-cycle progression, DNA repair,... 
MONOUBIQUITINATION | KAPPA-B ACTIVATION | LYS48-LINKED POLYUBIQUITIN CHAIN | atypical chain | ubiquitin-like protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | ubiquitin | MASS-SPECTROMETRY | CELL BIOLOGY | UBA DOMAIN | IN-VITRO | UBD | BINDING PROTEINS | CONJUGATING ENZYMES | DEGRADATION | signalling | Ubl | LIGASE | Polyubiquitin - metabolism | Protein Structure, Tertiary | Models, Molecular | Protein Binding | Signal Transduction - physiology | Protein Processing, Post-Translational | Polyubiquitin - chemistry | Polyubiquitin - classification | Proteins | Molecular biology | DNA repair | Binding sites | Cell cycle | Review
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3. Full Text Polyubiquitin chains: polymeric protein signals
by Pickart, Cecile M and Fushman, David
Current Opinion in Chemical Biology, ISSN 1367-5931, 2004, Volume 8, Issue 6, pp. 610 - 616
The 76-residue protein ubiquitin exists within eukaryotic cells both as a monomer and in the form of isopeptide-linked polymers called polyubiquitin chains. In... 
MUTANT | CONJUGATION | BIOPHYSICS | MULTIUBIQUITIN CHAIN | UBA DOMAINS | UBIQUITIN RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE | UBIQUITYLATION | DEGRADATION | DNA-REPAIR | BINDING | Polyubiquitin - metabolism | Animals | Signal Transduction | Ubiquitin-Protein Ligases - metabolism | Protein Binding | Protein Conformation | Lysine - metabolism | Dimerization | Polyubiquitin - chemistry | Ubiquitin | Polymers
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4. Full Text Building ubiquitin chains: E2 enzymes at work
by Rape, Michael and Ye, Yihong
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 11/2009, Volume 10, Issue 11, pp. 755 - 764
The modification of proteins with ubiquitin chains can change their localization, activity and/or stability. Although ubiquitylation requires the concerted... 
ANAPHASE-PROMOTING COMPLEX | KAPPA-B ACTIVATION | IN-VITRO | YEAST RAD6 | CONJUGATING ENZYME | POLYUBIQUITIN CHAINS | BRCA1/BARD1 HETERODIMER | MOLECULAR DETERMINANTS | DNA-REPAIR | ALLOSTERIC ACTIVATION | CELL BIOLOGY | Animals | Ubiquitin-Conjugating Enzymes - physiology | Humans | Ubiquitin - metabolism | Ubiquitin | Physiological aspects | Genetic aspects | Research | Ubiquitin-proteasome system | Ligases
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5. Full Text Why do cellular proteins linked to K63‐polyubiquitin chains not associate with proteasomes?
by Nathan, James A and Tae Kim, Hyoung and Ting, Lily and Gygi, Steven P and Goldberg, Alfred L
The EMBO Journal, ISSN 0261-4189, 02/2013, Volume 32, Issue 4, pp. 552 - 565
Although cellular proteins conjugated to K48‐linked Ub chains are targeted to proteasomes, proteins conjugated to K63‐ubiquitin chains are directed to... 
lysine‐48 | proteasome | lysine‐63 | polyubiquitin | ubiquitin binding protein | lysine-63 | lysine-48 | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 26S PROTEASOME | CELL BIOLOGY | MHC CLASS-I | FORKED UBIQUITIN CHAINS | RAD23 | DEGRADATION | POLYUBIQUITIN CHAINS | DNA-REPAIR | DOMAINS | BINDING | Polyubiquitin - metabolism | Rabbits | Endosomes - genetics | Lysosomes - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Rats | Endosomes - metabolism | Polyubiquitin - genetics | Proteasome Endopeptidase Complex - genetics | Animals | Lysosomes - metabolism | Ubiquitinated Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitinated Proteins - metabolism | Proteins | Amino acids | Cellular biology | Molecular biology
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6. Full Text Breaking the chains: structure and function of the deubiquitinases
by Clague, Michael J and Komander, David and Urbé, Sylvie
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 08/2009, Volume 10, Issue 8, pp. 550 - 563
Ubiquitylation is a reversible protein modification that is implicated in many cellular functions. Recently, much progress has been made in the... 
UBIQUITIN-SPECIFIC PROTEASES | QUANTITATIVE PROTEOMICS | FANCONI-ANEMIA PATHWAY | CRYSTAL-STRUCTURE | POLYUBIQUITIN CHAINS | PROTEIN UBIQUITINATION | CELL-CYCLE PROGRESSION | NF-KAPPA-B | C-TERMINAL HYDROLASES | ENZYME ATAXIN-3 | CELL BIOLOGY | Substrate Specificity | Endopeptidases - metabolism | Endopeptidases - chemistry | Animals | Biocatalysis | Humans | Post-translational modification | Enzymes | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Ubiquitin-proteasome system | Structure
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7. Full Text Total chemical synthesis of di-ubiquitin chains
by Kumar, K. S. Ajish and Spasser, Liat and Erlich, Lesly A and Bavikar, Sudhir N and Brik, Ashraf
Angewandte Chemie - International Edition, ISSN 1433-7851, 11/2010, Volume 49, Issue 48, pp. 9126 - 9131
peptides | ligation | proteins | synthetic methods | ubiquitin | PEPTIDE UBIQUITYLATION | CRYSTAL-STRUCTURE | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURAL BASIS | POLYUBIQUITIN CHAINS | DESULFURIZATION | BINDING | EFFICIENT | ISOPEPTIDASE-T | Models, Molecular | Molecular Sequence Data | Amino Acid Sequence | Polyubiquitin - chemical synthesis | Humans | Polyubiquitin - chemistry
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8. Full Text Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
by Licchesi, Julien D F and Wilkinson, Keith D and Odenwaelder, Peter and Barford, David and Reyes-Turcu, Francisca and Komander, David
EMBO reports, ISSN 1469-221X, 05/2009, Volume 10, Issue 5, pp. 466 - 473
At least eight types of ubiquitin chain exist, and individual linkages affect distinct cellular processes. The only distinguishing feature of differently... 
TAK1/IKK/NEMO/NF‐κB | ubiquitin binding domain | NF‐κB signalling | ubiquitin linkage | deubiquitinase | ACTIVATION | DOMAIN | NF-kappa B signalling | RECOGNITION | SPECIFICITY | TAK1/IKK/NEMO/NF-kappa B | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIGNALS | IKK | CELL BIOLOGY | UBIQUITIN CHAINS | NF-KAPPA-B | BINDING | NEMO | DNA-Binding Proteins - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endopeptidases - chemistry | Protein Structure, Secondary | Models, Molecular | Protein Binding | Crystallography, X-Ray | Lysine - chemistry | DNA-Binding Proteins - chemistry | Polyubiquitin - chemistry | Proteins | Signal transduction | Cellular biology | Molecular biology | Binding sites | NF-κB | TAK1 | NF-κB signalling | Scientific Report
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9. Full Text Heterotypic Ubiquitin Chains: Seeingis Believing
by Stolz, A and Dikic, I
TRENDS IN CELL BIOLOGY, ISSN 0962-8924, 01/2018, Volume 28, Issue 1, pp. 1 - 3
COMPLEX | POLYUBIQUITIN | CELL BIOLOGY
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10. Full Text Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
by Liu, Chao and Liu, Weixiao and Ye, Yihong and Li, Wei
Nature Communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, p. 14274
Ubiquitination of a subset of proteins by ubiquitin chain elongation factors (E4), represented by Ufd2p in Saccharomyces cerevisiae, is a pivotal regulator for... 
PROTEIN | RAD23 | STRUCTURAL BASIS | MECHANISTIC INSIGHTS | MULTIDISCIPLINARY SCIENCES | SCF | BINDING DOMAIN | UBIQUITYLATION | CONJUGATING ENZYME | POLYUBIQUITIN CHAINS | LIGASE COMPLEX | Saccharomyces cerevisiae - physiology | Proteolysis | Ubiquitin-Conjugating Enzymes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Lysine - metabolism | Ubiquitination - physiology | Proteasome Endopeptidase Complex - physiology | Ubiquitin - biosynthesis
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11. Full Text TRIM5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription
by Fletcher, Adam J and Christensen, Devin E and Nelson, Chad and Tan, Choon Ping and Schaller, Torsten and Lehner, Paul J and Sundquist, Wesley I and Towers, Greg J
The EMBO Journal, ISSN 0261-4189, 08/2015, Volume 34, Issue 15, pp. 2078 - 2095
TRIM 5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It... 
restriction | TRIM | Ube2W | ubiquitin | Ube2N | TRIM5α | TRIM FAMILY | RHESUS TRIM5-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE LEUKEMIA-VIRUS | PRYSPRY DOMAIN | TRIM5 alpha | CELL BIOLOGY | ANTIVIRAL DEFENSE | SIMIAN IMMUNODEFICIENCY VIRUS | POLYUBIQUITIN CHAINS | CAPSID LATTICE | HIV-1 INFECTION | RETROVIRAL RESTRICTION | Reverse Transcription - physiology | Carrier Proteins - metabolism | Mutagenesis, Site-Directed | RNA Interference | Models, Biological | Ubiquitin-Conjugating Enzymes - metabolism | Humans | HEK293 Cells | Ubiquitin - metabolism | HeLa Cells | RNA, Small Interfering - metabolism
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