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Cancer Discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1511 - 1514
Unleashing blocked apoptosis has emerged as an important tool in treating cancer as shown by the recent success of the BCL2 inhibitor venetoclax. However, MCL1... 
ONCOLOGY | POTENT
Journal Article
Clinical Toxicology, ISSN 1556-3650, 02/2018, Volume 56, Issue 2, pp. 151 - 152
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 06/2019, Volume 62, Issue 12, pp. 5863 - 5884
Lysyl oxidase (LOX) is a secreted copper dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator... 
POTENT | CHEMISTRY, MEDICINAL
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 1054 - 1066
JAK family kinases are important mediators of immune cell signaling and Janus Kinase 3 (JAK3) has long been indicated as a potential target for autoimmune... 
JAK3 | POTENT | CHEMISTRY, MEDICINAL
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4656 - 4668
Complement factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the... 
POTENT | CHEMISTRY, MEDICINAL | DISCOVERY
Journal Article
Potent vasoconstriction of the mesentric vessels by the venom extract of the sea anemone, Telia felina, 12/2002
Partially purified extract (extract IV) of the sea anemone, Tealia felina   was shown to have a vasoconstrictor effect on the mesenteric vessels of the rat.... 
Tealia felina, potent vasoconstriction, mesenteric vessels
Journal
Journal of Organic Chemistry, ISSN 0022-3263, 11/2018, Volume 83, Issue 22, pp. 14203 - 14209
The chemoselective amination of alkyl bromides and chlorides with aqueous ammonia and hydroxylamine was achieved in continuous flow to produce primary ammonium... 
CHEMISTRY, ORGANIC | POTENT | AGENTS | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2013, Volume 56, Issue 24, pp. 9820 - 9825
Diacylglycerol O-acyltransferase 1 (DGAT1) has recently become a highly interesting target for metabolic disorders as well as for hepatitis C virus (HCV).... 
POTENT | CHEMISTRY, MEDICINAL | MECHANISM | PHARMACOLOGICAL INHIBITION | DISCOVERY
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2015, Volume 13, Issue 48, pp. 11674 - 11686
A new family of novel highly fluorescent pi-conjugated, C7-imidazole based indolizine derivatives has been prepared in good to excellent yields, catalysed by... 
CHEMISTRY, ORGANIC | POTENT INHIBITORS
Journal Article
by Ma, YY and Li, LF and He, S and Shang, CY and Sun, Y and Liu, N and Meek, TD and Wang, YX and Shang, LQ
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6146 - 6162
Targeted covalent inhibitors (TCIs) have attracted growing attention from the pharmaceutical industry in recent decades because they have potential advantages... 
BIOLOGICAL EVALUATION | POTENT | CHEMISTRY, MEDICINAL | DRUG DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6137 - 6145
The Plasmodium proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite life cycle and... 
POTENT | CHEMISTRY, MEDICINAL | NONCOVALENT INHIBITORS | ARTEMISININ RESISTANCE
Journal Article
by Zhong, LK and Zhang, F and Jiang, T and Liu, XH and Xu, TM and Ding, CR and Chen, J and Yuan, J and Tan, CX
HETEROCYCLES, ISSN 0385-5414, 05/2019, Volume 98, Issue 5, pp. 637 - 649
Pyrazole and its derivatives are a kind of important heterocyclic compounds used in agrochemicals development. In this research, a series of novel... 
CHEMISTRY, ORGANIC | POTENT | DERIVATIVES | DISCOVERY
Journal Article
Organic Letters, ISSN 1523-7060, 02/2017, Volume 19, Issue 3, pp. 734 - 737
Three dimeric sesquiterpenoids (1-3), fortunoid A (1) possessing a new carbon skeleton of rearranged lindenane dimer and fortunoids B (2) and C (3)... 
BLOCKERS | CHEMISTRY, ORGANIC | HOLOSTEGIUS | POTENT | SERRATUS
Journal Article
HETEROCYCLES, ISSN 0385-5414, 04/2019, Volume 99, Issue 1, pp. 238 - 247
Various analogues of gatastatin, a gamma-tubulin-specific inhibitor, were designed and synthesized by systematically optimizing the aromatic ring at the... 
ISOFLAVONE | CHEMISTRY, ORGANIC | POTENT | GLAZIOVIANIN-A
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 02/2019, Volume 25, Issue 4, pp. 1404 - 1414
Purpose: The catalytic function of BUB1 is required for chromosome arm resolution and positioning of the chromosomal passenger complex for resolution of... 
POTENT | CHECKPOINT | ONCOLOGY | DEFICIENCY | DNA-DAMAGE
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4401 - 4410
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we... 
CFI-402257 | POTENT | CHEMISTRY, MEDICINAL | CHECKPOINT | MPS1 | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2019, Volume 62, Issue 8, pp. 3873 - 3885
The Food and Drug Administration-approved antifungal agent, itraconazole (ITZ), has been increasingly studied for its novel biological properties. In... 
AGENT | RESISTANCE | POTENT | CHEMISTRY, MEDICINAL | ANTIFUNGAL | MEDULLOBLASTOMA
Journal Article
Organic Letters, ISSN 1523-7060, 12/2016, Volume 18, Issue 23, pp. 6180 - 6183
An efficient photoredox/Ni dual catalytic C-sp(2-) C-sp(3) cross-coupling protocol in a continuous-flow regime to synthesize a variety of regioisomeric... 
CHEMISTRY, ORGANIC | PHOTOCHEMISTRY | POTENT | INHIBITORS | TECHNOLOGY | DISCOVERY
Journal Article
Linear Algebra and Its Applications, ISSN 0024-3795, 02/2013, Volume 438, Issue 4, pp. 1517 - 1531
Journal Article
Organic Letters, ISSN 1523-7060, 11/2018, Volume 20, Issue 22, pp. 7304 - 7307
The first total synthesis of the fungal natural product suillusin is reported. The key features of the synthesis include a Michael-benzoin multicatalytic... 
OXIDATION | CHEMISTRY, ORGANIC | POTENT | FLAVAGLINES | ANTICANCER | DERIVATIVES
Journal Article
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