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Journal of Chemical Information and Modeling, ISSN 1549-9596, 03/2008, Volume 48, Issue 3, pp. 646 - 658
A new method for analyzing a structure−activity relationship is proposed. By use of a simple quantitative index, one can readily identify “structure−activity... 
HUMAN MELANOCORTIN-4 RECEPTOR | POTENT | CHEMISTRY, MEDICINAL | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | SAR | COMPUTER SCIENCE, INFORMATION SYSTEMS | ANTAGONISTS | DIHYDROQUINOLINE | AGONISTS | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2019, Volume 62, Issue 12, pp. 5810 - 5831
There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a... 
SYSTEM | POTENT | CHEMISTRY, MEDICINAL | ENTRY | OPTIMIZATION | DISCOVERY | SCAFFOLD
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2016, Volume 24, Issue 8, pp. 1898 - 1908
Journal Article
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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 7, pp. 2269 - 2281
Novel ring scaffold as dual cholinesterase and Aβ-aggregation inhibitors. A novel class of 2,4-disubstituted pyrimidines ( – , – , – ) that possess... 
Cholinesterase inhibitors (ChEIs) | Butyrylcholinesterase (BuChE) | Amyloid-β (Aβ) | Human acetylcholinesterase ( hAChE) | Acetylcholinesterase (AChE) | Structure–activity relationship (SAR) | 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) | Thioflavin T (ThT) | 5,5′-Dithiobis(2-nitrobenzoic acid) (DTNB) | Structure-activity relationship (SAR) | Human acetylcholinesterase (hAChE) | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | ASSAY | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | TOXICITY | DISCOVERY | POTENT | 5,5 '-Dithiobis(2-nitrobenzoic acid) (DTNB) | Amyloid-beta (A beta) | ACETYLCHOLINESTERASE | LIGANDS | GENERATION | AMYLOID AGGREGATION | Amyloid beta-Peptides - antagonists & inhibitors | Cholinesterase Inhibitors - pharmacology | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Drug Design | Models, Molecular | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Amyloid beta-Peptides - chemistry | Pyrimidines - pharmacology | Pyrimidines - chemistry | Structure-activity relationship SAR | Thioflavin T ThT | 5,5'-dithiobis(2-nitrobenzoic acid), DTNB | Butyrylcholinesterase BuChE | Cholinesterase inhibitors ChEIs | Human acetylcholinesterase hAChE | 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide MTT | Acetylcholinesterase AChE | Amyloid-β Aβ
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3499 - 3512
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2006, Volume 16, Issue 10, pp. 2710 - 2713
A series of novel α-glucosidase inhibitors were reported and the structure–activity relationships were analyzed. A series of analogues of andrographolide were... 
Glucosidase | Inhibition | Andrographolide | Analogues | analogues | POTENT | CHEMISTRY, MEDICINAL | glucosidase | CHEMISTRY, ORGANIC | inhibition | DIABETIC-RATS | PANICULATA | CASTANOSPERMINE | andrographolide | Diterpenes - pharmacology | Glycoside Hydrolase Inhibitors | Animals | Enzyme Inhibitors - pharmacology | Rats | Structure-Activity Relationship | Diterpenes - chemistry
Journal Article
Journal Article