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Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7601, pp. 105 - 109
Despite the success of potent anti-retroviral drugs in controlling human immunodeficiency virus type 1 (HIV-1) infection, little progress has been made in... 
SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS | POTENT | TRANSMISSION | HIV-1/SIV CHIMERIC VIRUS | BROADLY NEUTRALIZING ANTIBODY | MULTIDISCIPLINARY SCIENCES | IMPROVES PROTECTION | PASSIVE TRANSFER | MACAQUES | INFECTION | MONOCLONAL-ANTIBODIES | HIV Antibodies - blood | Antibodies, Neutralizing - administration & dosage | HIV Infections - prevention & control | AIDS Vaccines - immunology | Macaca mulatta - immunology | Half-Life | Male | Antibodies, Monoclonal - blood | HIV Infections - immunology | Macaca mulatta - virology | Antibodies, Neutralizing - immunology | Immunoglobulin Fc Fragments - immunology | HIV Antibodies - immunology | Time Factors | Female | HIV Infections - transmission | Antibodies, Monoclonal - immunology | Simian Immunodeficiency Virus - immunology | Protein Structure, Tertiary | SAIDS Vaccines - administration & dosage | Immunoglobulin Fc Fragments - chemistry | Antibodies, Neutralizing - genetics | Mutation - genetics | Simian Acquired Immunodeficiency Syndrome - blood | HIV Antibodies - administration & dosage | Simian Acquired Immunodeficiency Syndrome - prevention & control | Antibodies, Monoclonal - genetics | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Antibodies, Monoclonal - administration & dosage | HIV Antibodies - genetics | AIDS Vaccines - administration & dosage | Immunoglobulin Fc Fragments - genetics | Antibodies, Neutralizing - blood | Prevention | Viral antibodies | Antibodies | Dosage and administration | HIV infection | Patient outcomes | Monoclonal antibodies | Immunoglobulins | Immunization | Vaccines | Human immunodeficiency virus--HIV | Viral infections
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 04/2019, Volume 18, Issue 4, pp. 780 - 787
To provide a better understanding of the pharmacoldnetics-pharmacodynamics relationships of antibody-based drugs, we analyzed several chimeric and humanized... 
AURISTATIN | POTENT | MODELS | PHARMACOKINETICS | ONCOLOGY | THERAPEUTIC ANTIBODIES | RECEPTOR | MICE | ANTITUMOR-ACTIVITY | DISCOVERY
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 877 - 12
HIV-1 broadly neutralizing antibodies (bNAbs) are being explored as passively administered therapeutic and preventative agents. However, the extensively... 
BISPECIFIC ANTIBODIES | SHIV INFECTION | POTENT NEUTRALIZATION | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | IMPROVES PROTECTION | CD4 BINDING | HUMAN MONOCLONAL-ANTIBODIES | HUMAN-IMMUNODEFICIENCY-VIRUS | FITNESS COST | BREADTH | Protein Subunits - immunology | env Gene Products, Human Immunodeficiency Virus - immunology | Antiviral Agents - immunology | Humans | Epitopes - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV Antibodies - immunology | Antiviral Agents - chemistry | Antibodies, Neutralizing - therapeutic use | env Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Drug Design | Single-Chain Antibodies - therapeutic use | HIV Antibodies - therapeutic use | HIV Antibodies - pharmacology | Antiviral Agents - pharmacology | Single-Chain Antibodies - pharmacology | Antiviral Agents - therapeutic use | HIV-1 - drug effects | Antibodies, Neutralizing - pharmacology | Epitopes - genetics | HIV-1 - genetics | Microscopy, Electron | HIV Antibodies - chemistry | HIV-1 - immunology | Antibodies, Neutralizing - chemistry | HIV Infections - drug therapy | Mutation | Drug Combinations | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology | Antiviral agents | Antibodies | Crosslinking | Glycoproteins | Pharmacology | Epitopes | Chemical compounds | Glycan | CD4 antigen | Human immunodeficiency virus--HIV | Avidity | Binding sites | Neutralization
Journal Article
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 185 - 191
Monoclonal antibody 10-1074 targets the V3 glycan supersite on the HIV-1 envelope (Env) protein. It is among the most potent anti-HIV-1 neutralizing antibodies... 
POTENT HIV-ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PASSIVE TRANSFER | TREATMENT INTERRUPTION | HUMANIZED MICE | CELL BIOLOGY | BROADLY NEUTRALIZING ANTIBODIES | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | GLYCAN RECOGNITION | CD4 BINDING | HUMAN MONOCLONAL-ANTIBODIES
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7377, pp. 336 - 343
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody... 
SYSTEM | POTENT NEUTRALIZATION | DEXTRAN SULFATE | EPITOPE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENVELOPE GLYCOPROTEIN | RECEPTOR | BINDING | T-CELLS | SOFTWARE | AIDS Vaccines - immunology | Glycopeptides - chemistry | Molecular Sequence Data | Antibody Affinity - immunology | Crystallography, X-Ray | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Glycopeptides - immunology | Antibody Specificity - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Protein Structure, Quaternary | Conserved Sequence | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Binding Sites, Antibody - immunology | Models, Molecular | Glycosylation | Polysaccharides - immunology | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Amino Acid Motifs | HIV-1 - immunology | Immune Evasion | Hydrogen Bonding | Antigen-Antibody Complex - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | Antigen-Antibody Complex - immunology | Viral envelopes | Genetic aspects | Research | HIV (Viruses) | Structure | Binding sites (Biochemistry) | Proteins | Crystals | Vaccines | ANTIBODIES | AIDS VIRUS | BASIC BIOLOGICAL SCIENCES | AFFINITY | BIOLOGY | GLYCOPROTEINS | VULNERABILITY | ANTIGENS | IMMUNOLOGY | 60 APPLIED LIFE SCIENCES
Journal Article
by Liao, Hua-Xin and Lynch, Rebecca and Zhou, Tongqing and Gao, Feng and Munir Alam, S and Boyd, Scott D and Fire, Andrew Z and Roskin, Krishna M and Schramm, Chaim A and Zhang, Zhenhai and Zhu, Jiang and Shapiro, Lawrence and Mullikin, James C and Gnanakaran, S and Hraber, Peter and Wiehe, Kevin and Kelsoe, Garnett and Yang, Guang and Xia, Shi-Mao and Montefiori, David C and Parks, Robert and Lloyd, Krissey E and Scearce, Richard M and Soderberg, Kelly A and Cohen, Myron and Kamanga, Gift and Louder, Mark K and Tran, Lillian M and Chen, Yue and Cai, Fangping and Chen, Sheri and Moquin, Stephanie and Du, Xiulian and Gordon Joyce, M and Srivatsan, Sanjay and Zhang, Baoshan and Zheng, Anqi and Shaw, George M and Hahn, Beatrice H and Kepler, Thomas B and Korber, Bette T. M and Kwong, Peter D and Mascola, John R and Haynes, Barton F and Becker, Jesse and Benjamin, Betty and Blakesley, Robert and Bouffard, Gerry and Brooks, Shelise and Coleman, Holly and Dekhtyar, Mila and Gregory, Michael and Guan, Xiaobin and Gupta, Jyoti and Han, Joel and Hargrove, April and Ho, Shi-Ling and Johnson, Taccara and Legaspi, Richelle and Lovett, Sean and Maduro, Quino and Masiello, Cathy and Maskeri, Baishali and McDowell, Jenny and Montemayor, Casandra and Mulliki, James and Park, Morgan and Riebow, Nancy and Schandler, Karen and Schmidt, Brian and Sison, Christina and Stantripop, Mal and Thomas, James and Thomas, Pam and Vemulapalli, Meg and Young, Alice and NISC Comparative Sequencing Progra and NISC Comparative Sequencing Program
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7446, pp. 469 - 476
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise... 
CRYSTALLIZATION | B-CELL RESPONSES | CONFORMATIONAL EPITOPE | POTENT NEUTRALIZATION | EVOLUTION | CD4 BINDING-SITE | MULTIDISCIPLINARY SCIENCES | ENVELOPE GLYCOPROTEIN | HUMAN MONOCLONAL-ANTIBODIES | SUBTYPE-B | IN-SITU PROTEOLYSIS | HIV Envelope Protein gp120 - genetics | Clone Cells - cytology | Humans | AIDS Vaccines - immunology | Molecular Sequence Data | Crystallography, X-Ray | Neutralization Tests | Phylogeny | HIV Envelope Protein gp120 - metabolism | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | HIV Envelope Protein gp120 - chemistry | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Protein Structure, Tertiary | Amino Acid Sequence | CD4 Antigens - immunology | Africa | Cells, Cultured | Models, Molecular | Antibodies, Neutralizing - genetics | Cross Reactions - immunology | HIV Antibodies - chemistry | HIV-1 - classification | Antibodies, Monoclonal - genetics | Cell Lineage | HIV-1 - immunology | CD4 Antigens - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | HIV Antibodies - genetics | Mutation | Evolution, Molecular | Monoclonal antibodies | AIDS vaccines | Genetic aspects | Research | HIV (Viruses) | Properties | Proteins | Plasma | Infections | Patients | Binding sites | Crystal structure
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 804 - 813
HIV-1 uses a diverse N-linked-glycan shield to evade recognition by antibody. Select human antibodies, such as the clonally related PG9 and PG16, recognize... 
COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP120 | 2G12 RECOGNIZES | GLYCOSYLATION SITES | CELL BIOLOGY | POTENT | BIOPHYSICS | HAMSTER OVARY CELLS | BROADLY NEUTRALIZING ANTIBODIES | IMMUNODEFICIENCY-VIRUS TYPE-1 | HIV-1 ENVELOPE GLYCOPROTEINS | Antibody Specificity | Epitopes - metabolism | Humans | Antibodies, Neutralizing - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Glycosylation - drug effects | HIV Envelope Protein gp120 - metabolism | Antigen-Antibody Reactions | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | Immunoglobulin Fab Fragments - metabolism | Protein Processing, Post-Translational - drug effects | Peptide Fragments - immunology | HEK293 Cells | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Swainsonine - pharmacology | Carbohydrate Sequence | HIV Antibodies - metabolism | Amino Acid Sequence | Peptide Fragments - metabolism | Models, Molecular | Polysaccharides - immunology | HIV Antibodies - chemistry | Amino Acid Motifs | Polysaccharides - metabolism | Peptide Fragments - chemistry | Antibodies, Neutralizing - chemistry | Protein Conformation | Epitopes - chemistry | Immunoglobulin Fab Fragments - immunology | Binding Sites, Antibody | Carbohydrate Conformation | Antigen-antibody reactions | Physiological aspects | Genetic aspects | Research | HIV (Viruses) | Structure | Health aspects | Antigenic determinants | Mutagenesis | Molecular biology | Human immunodeficiency virus--HIV | Polyclonal antibodies
Journal Article