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1. Full Text Antitumor Activity of MLN8054, an Orally Active Small-Molecule Inhibitor of Aurora A Kinase
by Mark G. Manfredi and Jeffrey A. Ecsedy and Kristan A. Meetze and Suresh K. Balani and Olga Burenkova and Wei Chen and Katherine M. Galvin and Kara M. Hoar and Jessica J. Huck and Patrick J. LeRoy and Emily T. Ray and Todd B. Sells and Bradley Stringer and Stephen G. Stroud and Tricia J. Vos and Gabriel S. Weatherhead and Deborah R. Wysong and Mengkun Zhang and Joseph B. Bolen and Christopher F. Claiborne
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2007, Volume 104, Issue 10, pp. 4106 - 4111
Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and... 
HCT116 cells | B lymphocytes | Cell lines | HeLa cells | Antibodies | Cellular immunity | Inhibitory concentration 50 | Tumors | Apoptosis | Mitotic spindle apparatus | Mitosis | Cancer | SUPPRESSES TUMOR-GROWTH | PROTEIN | CENTROSOME | MULTIDISCIPLINARY SCIENCES | CHROMOSOME CONDENSATION | apoptosis | SPINDLE ASSEMBLY CHECKPOINT | mitosis | CELL-DIVISION | POTENT | MITOTIC ENTRY | HISTONE H3 | B KINASE | cancer | Neoplasm Transplantation | Administration, Oral | Humans | Enzyme Inhibitors - pharmacology | Male | Aurora Kinases | Benzazepines - pharmacology | Disease Progression | Aurora Kinase A | Dose-Response Relationship, Drug | Aurora Kinase B | Animals | Mice, Nude | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Inhibitory Concentration 50 | Female | Antineoplastic Agents - pharmacology | Mice | Development and progression | Research | Biological Sciences
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2. Full Text Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives
by Congiu, Cenzo and Onnis, Valentina and Vesci, Loredana and Castorina, Massimo and Pisano, Claudio
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 17, pp. 6238 - 6248
A series of 3,5-diaryl-4,5-dihydropyrazole regioisomers, and their 1-acetylated derivatives, bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of... 
Antitumor activity | Cytotoxicity | Tubulin | Dihydropyrazole | CHEMISTRY, MEDICINAL | VASCULAR DISRUPTING AGENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | TUBULIN POLYMERIZATION | ANTIMITOTIC AGENTS | CHEMISTRY, ORGANIC | NATIONAL-CANCER-INSTITUTE | COMBRETASTATIN A-4 ANALOGS | POTENT | INHIBITORS | TUMOR-CELL-LINES | Tubulin Modulators | Pyrazoles - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Structure-Activity Relationship | Tumor Cells, Cultured | Drug Screening Assays, Antitumor | Pyrazoles - pharmacology
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3. Full Text 1-Amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity
by Miller-Moslin, Karen and Peukert, Stefan and Jain, Rishi K and McEwan, Michael A and Karki, Rajesh and Llamas, Luis and Yusuff, Naeem and He, Feng and Li, Yanhong and Sun, Yingchuan and Dai, Miao and Perez, Lawrence and Michael, Walter and Sheng, Tao and Lei, Huangshu and Zhang, Rui and Williams, Juliet and Bourret, Aaron and Ramamurthy, Arun and Yuan, Jing and Guo, Ribo and Matsumoto, Melissa and Vattay, Anthony and Maniara, Wieslawa and Amaral, Adam and Dorsch, Marion and Kelleher III, Joseph F
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 13, pp. 3954 - 3968
Abnormal activation of the Hedgehog (Hh) signaling pathway has been linked to several types of human cancers, and the development of small-molecule inhibitors... 
CHEMISTRY, MEDICINAL | SONIC HEDGEHOG | NITRILES | CYCLOPAMINE | MICE | POTENT INHIBITORS | MEDULLOBLASTOMA | CANCER | ARYLAMINES | HEDGEHOG SIGNALING PATHWAY | SMALL-MOLECULE INHIBITOR | Administration, Oral | Phthalazines - pharmacokinetics | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - therapeutic use | Structure-Activity Relationship | Phthalazines - chemistry | Antineoplastic Agents - chemistry | Phthalazines - therapeutic use | Animals | Signal Transduction - drug effects | Smoothened Receptor | Receptors, G-Protein-Coupled - antagonists & inhibitors | Antineoplastic Agents - pharmacokinetics | Mice | Medulloblastoma - drug therapy | Neoplasms, Experimental - drug therapy
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4. Full Text Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles
by Yamada, Mizuki and Takahashi, Tsutomu and Hasegawa, Mai and Matsumura, Mio and Ono, Kanna and Fujimoto, Ryota and Kitamura, Yuki and Murata, Yuki and Kakusawa, Naoki and Tanaka, Motohiro and Obata, Tohru and Fujiwara, Yasuyuki and Yasuike, Shuji
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2018, Volume 28, Issue 2, pp. 152 - 154
Trisubstituted 5-organostibano-1 -1,2,3-triazoles ( ) were synthesized by the Cu-catalyzed azide-alkyne cycloaddition of various ethynylstibanes ( ) with... 
Antimony | Cytotoxicity | 5-Stibanotriazole | Cu-catalyzed azide-alkyne cycloaddition | Antitumor | CELLS | CHEMISTRY, MEDICINAL | CLICK CHEMISTRY | CHEMISTRY, ORGANIC | ORGANOBISMUTH COMPOUND | DISCOVERY | POTENT | INHIBITORS | Triazoles | Tumors | Endothelium
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5. Full Text Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes
by Lovejoy, David B and Jansson, Patric J and Brunk, Ulf T and Wong, Jacky and Ponka, Prem and Richardson, Des R and Institutionen för medicin och hälsa and Farmakologi and Linköpings universitet and Hälsouniversitetet
Cancer Research, ISSN 0008-5472, 09/2011, Volume 71, Issue 17, pp. 5871 - 5880
The metal-chelating compound Dp44mT is a di-2-pyridylketone thiosemicarbazone (DpT) which displays potent and selective antitumor activity. This compound is... 
CANCER-CELLS | APOPTOSIS | POTENT | INHIBITION | TRANSFERRIN | ONCOLOGY | IRON CHELATORS | AGENTS | DEATH | Lysosomes - drug effects | Acridine Orange - metabolism | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Humans | Chelating Agents - pharmacology | Mitochondria - drug effects | Iron - metabolism | Antineoplastic Agents - metabolism | Lysosomes - metabolism | Copper - metabolism | Thiosemicarbazones - metabolism | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Chelating Agents - metabolism | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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6. Full Text Inhibition of Hsp90 suppresses PI3K/AKT/mTOR signaling and has antitumor activity in Burkitt lymphoma
by Giulino-Roth, Lisa and Van Besien, Herman J and Dalton, Tanner and Totonchy, Jennifer E and Rodina, Anna and Taldone, Tony and Bolaender, Alexander and Erdjument-Bromage, Hediye and Sadek, Jouliana and Chadburn, Amy and Barth, Matthew J and Dela Cruz, Filemon S and Rainey, Allison and Kung, Andrew L and Chiosis, Gabriela and Cesarman, Ethel
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1779 - 1790
Hsp90 is a molecular chaperone that protects proteins, including oncogenic signaling complexes, from proteolytic degradation. PU-H71 is a next-generation Hsp90... 
HEAT-SHOCK PROTEINS | B-CELL LYMPHOMA | POTENT | ONCOLOGY | NON-HODGKIN-LYMPHOMA | TARGETS | MUTATIONS | IDENTIFICATION | CANCER-THERAPY | DISCOVERY | TRANSPLANTATION | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Male | Phosphatidylinositol 3-Kinases - metabolism | Burkitt Lymphoma - pathology | Burkitt Lymphoma - genetics | Tumor Burden - genetics | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Proteomics - methods | Proto-Oncogene Proteins c-akt - metabolism | Burkitt Lymphoma - drug therapy | Cell Survival - drug effects | Gene Expression | Burkitt Lymphoma - metabolism | Drug Synergism | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Mice | TOR protein | Hsp90 protein | Tumor cells | Mass spectroscopy | AKT protein | Myc protein | Kinases | Lymphoma | 1-Phosphatidylinositol 3-kinase | Anticancer properties | Burkitt's lymphoma | Proteins | Signaling | Lymphocytes B | Proteolysis | Xenografts | Antitumor activity | Lymphomas | Inhibition | Mass spectrometry | Tumors | Cancer | B-cell lymphoma
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7. Adenosine: Synthetic methods of its derivatives and antitumor activity
by Valdés, Francisco Z and Luna, Víctor Z and Arévalo, Bárbara R and Brown, Nelson V and Gutiérrez, Margarita C
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2018, Volume 18, Issue 20, pp. 1684 - 1701
Since 1929, several researchers have conducted studies in relation to the nucleoside of adenosine (1) mainly distribution identifying, characterizing their... 
A | Adenosine | ACTIVATION | CHEMISTRY, MEDICINAL | substitution | TRANSPORTERS | RECEPTOR AGONISTS | TRANSCRIPTION | adenosine derivatives | complexing | conjugation | NUCLEOTIDES | POTENT | glioblastoma | INHIBITION | adenosine receptors | SELECTIVE AGONISTS | N-DONOR LIGANDS | Antineoplastic Agents - chemical synthesis | Humans | Brain Neoplasms - pathology | Aza Compounds - chemistry | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Brain Neoplasms - drug therapy | Sulfonic Acids - chemistry | Receptors, Purinergic P1 - chemistry | Adenosine - analogs & derivatives | Adenosine - therapeutic use | Glioblastoma - pathology | Adenosine - metabolism | Receptors, Purinergic P1 - metabolism | Glioblastoma - drug therapy
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8. Full Text Enrichment of novel quinazoline derivatives with high antitumor activity in mitochondria tracked by its self-fluorescence
by Zhang, Yaling and Hou, Qiaoli and Li, Xiabing and Li, Baolin and Zhu, Jiuling and Wang, Wei and Zhao, Lijun and Xia, Haibin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 178, pp. 417 - 432
In novel synthetic 28 4-arylamino-6-fluoro quinazoline derivatives, compound displayed the most remarkable inhibitory activities against tumor cells (IC values... 
Antitumor activity | Mitochondria | Quinazoline | Self-fluorescence | APOPTOSIS | DESIGN | CHEMISTRY, MEDICINAL | MOIETY | TYROSINE KINASE | POTENT EGFR INHIBITORS | CANCER | GROWTH-FACTOR RECEPTOR | ANTICANCER | BIOLOGICAL EVALUATION | ENHANCED ANTIPROLIFERATIVE ACTIVITIES | Cytochrome c | Phosphates | Fluorescence | Analysis
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9. Full Text High antitumor activity of Sortase A-generated anti-CD20 antibody fragment drug conjugates
by Liu, Wenhui and Zhao, Wenbin and Bai, Xuefei and Jin, Shijie and Li, Yiming and Qiu, Chixiao and Pan, Liqiang and Ding, Ding and Xu, Yingchun and Zhou, Zhan and Chen, Shuqing
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 06/2019, Volume 134, pp. 81 - 92
Antibody fragments, as the products of engineered antibodies, exhibit great potential for cancer therapy and imaging. Antibody fragment drug conjugates... 
Antibody fragment drug conjugates | Sortase A | Anti-CD20 antibody | Fab | Fab-CH3mut | FAB FRAGMENT | ELIMINATION | MONOCLONAL-ANTIBODY | TUMORS | CANCER-THERAPY | POTENT | MELANOMA | PHARMACOLOGY & PHARMACY | EXPRESSION | Biopharmaceutics | Ofatumumab | Tumors
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10. Full Text Selective inhibitors of Bcl-2 and Bcl-x(L): Balancing antitumor activity with on-target toxicity
by Hennessy, EJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 05/2016, Volume 26, Issue 9, pp. 2105 - 2114
The induction of apoptosis in tumor cells represents a promising approach to the treatment of cancer. Accordingly, compounds that interact with the Bcl-2... 
CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | Bcl-2 family proteins | Selectivity | FAMILY PROTEINS | Protein-protein interactions | DISCOVERY | SMALL-MOLECULE INHIBITOR | IN-VITRO | POTENT | CHEMORESISTANCE | ANTAGONISTS | NAVITOCLAX | ABT-199 | Apoptosis
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11. Full Text Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives
by Csuk, René and Schwarz, Stefan and Siewert, Bianka and Kluge, Ralph and Ströhl, Dieter
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2011, Volume 46, Issue 11, pp. 5356 - 5369
Triterpenoic acids show many pharmacological effects, among them an antiinflammatory or an antitumor activity. One of these, glycyrrhetinic acid ( ) is of... 
Antitumor activity | Glycyrrhetinic acid | Apoptosis | POTENT | CHEMISTRY, MEDICINAL | CANCER CELLS | INHIBITORS | GLYCYRRHIZIN | REDUCTIVE AMINATION | Glycyrrhetinic Acid - chemical synthesis | Glycyrrhetinic Acid - pharmacology | Chemistry Techniques, Synthetic | Apoptosis - drug effects | Glycyrrhetinic Acid - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Antineoplastic Agents - chemistry
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12. Full Text Hybrid compounds with two redox centres: Modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity
by Vieira, André A and Brandão, Igor R and Valença, Wagner O and de Simone, Carlos A and Cavalcanti, Bruno C and Pessoa, Claudia and Carneiro, Teiliane R and Braga, Antonio L and da Silva, Eufrânio N
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2015, Volume 101, pp. 254 - 265
Chalcogen-containing β-lapachone derivatives were synthesized using a straightforward methodology and evaluated against several cancer cell lines (leukaemia,... 
Selenide | Quinone | Antitumor | β-lapachone | Selenium | Sulfur | Anticancer | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | beta-lapachone | QUINONES | TRYPANOCIDAL ACTIVITY | DERIVATIVES SYNTHESIS | POTENT ACTIVITY | IN-VITRO | CANCER-CELL LINES | X-RAY | CYTOTOXICITY | Cell Line | Oxidation-Reduction | Antineoplastic Agents - chemical synthesis | Humans | Models, Molecular | Naphthoquinones - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Naphthoquinones - chemical synthesis | Dose-Response Relationship, Drug | Animals | Naphthoquinones - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Structure | Chalcogens - chemistry | Drug Screening Assays, Antitumor | Leukemia | Colon cancer | Sulfur compounds | Metastasis | Derivatives (Financial instruments)
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13. Full Text Synthesis and antitumor activity of benzils related to combretastatin A-4
by Mousset, Céline and Giraud, Anne and Provot, Olivier and Hamze, Abdallah and Bignon, Jérôme and Liu, Jian-Miao and Thoret, Sylviane and Dubois, Joëlle and Brion, Jean-Daniel and Alami, Mouâd
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 11, pp. 3266 - 3271
Benzil derivatives related to combretastatin A-4 exhibit excellent antiproliferative and antimitotic activities by arresting the cell cycle in G2/M phase. A... 
Antiproliferative | Antitumor | Combretastatin | Benzils | Oxidation | Inhibition of tubulin assembly | Antimitotic | Antiangiogenic | Alkynes | benzils | CHEMISTRY, MEDICINAL | INHIBIT TUBULIN POLYMERIZATION | antitumor | ANALOGS | antiangiogenic | ANTICANCER AGENTS | alkynes | oxidation | ANTINEOPLASTIC AGENTS | ANTIMITOTIC AGENTS | CHEMISTRY, ORGANIC | antimitotic | CELL-GROWTH | antiproliferative | combretastatin | POTENT | COLCHICINE | DIARYLALKYNES | inhibition of tubulin assembly | DERIVATIVES | Tubulin Modulators - chemistry | Antineoplastic Agents, Phytogenic - chemical synthesis | Tubulin Modulators - pharmacology | Humans | Stilbenes - chemical synthesis | Phenylglyoxal - pharmacology | Phenylglyoxal - analogs & derivatives | Antineoplastic Agents, Phytogenic - chemistry | Stilbenes - chemistry | Structure-Activity Relationship | Phenylglyoxal - chemical synthesis | Stilbenes - pharmacology | Tubulin Modulators - chemical synthesis | Combinatorial Chemistry Techniques | Cell Cycle | Inhibitory Concentration 50 | Antineoplastic Agents, Phytogenic - pharmacology | Drug Screening Assays, Antitumor | Phenylglyoxal - chemistry | Antimitotic agents | Antineoplastic agents | Index Medicus | Life Sciences | Cellular Biology
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14. Full Text Interleukin-24 enhancing antitumor activity of chimeric oncolytic adenovirus for treating acute promyelocytic leukemia cell
by Liu, L and Ma, JB and Qin, LY and Shi, XG and Si, HQ and Wei, YH
MEDICINE, ISSN 0025-7974, 05/2019, Volume 98, Issue 22, p. e15875
Background: Acute promyelocytic leukaemia (APL) is a clonal disease arising by hematopoietic stem cell (HSC), which characterized by inappropriate... 
APOPTOSIS | MDA-7/IL-24 | CANCER CELLS | interleukin-24 | CLINICAL-EXPERIENCE | cancer therapy | MEDICINE, GENERAL & INTERNAL | POTENT | acute promyelocytic leukemia | THERAPY | REPLICATION | GROWTH | chimeric oncolytic adenovirus | GENE-TRANSFER | PROMOTER | Oncolytic Virotherapy - methods | Humans | Oncolytic Viruses - immunology | HEK293 Cells | Leukemia, Promyelocytic, Acute - immunology | HL-60 Cells | Adenovirus Early Proteins - genetics | Adenovirus Early Proteins - pharmacology | Interleukins - metabolism | Chimera | Leukemia, Promyelocytic, Acute - drug therapy | Interleukins | Health aspects | Genetic aspects
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15. Full Text Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: Identification of pronounced redox activity and characterization of their antitumor activity
by Jansson, Patric J and Sharpe, Philip C and Bernhardt, Paul V and Richardson, Des R
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2010, Volume 53, Issue 15, pp. 5759 - 5769
The novel chelators 2-acetylpyridine-4,4-dimethyl-3-thiosemicarbazone (HAp44mT) and di-2-pyridyl-ketone-4,4-dimethyl-3-thiosemicarbazone (HDp44mT) have been... 
CANCER-CELLS | RIBONUCLEOTIDE REDUCTASE | OXIDATIVE STRESS | ANTIPROLIFERATIVE ACTIVITY | CHEMISTRY, MEDICINAL | POTENT IRON CHELATORS | INHIBITION | TRANSFERRIN | GLUTATHIONE | HYDRAZONE | AGENTS | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Glutathione Disulfide - metabolism | Structure-Activity Relationship | Thiosemicarbazones - chemistry | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Copper | Oxidation-Reduction | Chelating Agents - chemistry | Pyridines - chemical synthesis | Thiosemicarbazones - chemical synthesis | Chelating Agents - pharmacology | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Ligands | Cell Proliferation - drug effects | Pyridines - pharmacology | Chelating Agents - chemical synthesis | Drug Screening Assays, Antitumor
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16. Full Text Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors
by Hei, Yuan-Yuan and Xin, Minhang and Zhang, San-Qi and Zhang, Hao and Xie, Xiao-Xiao and Mao, Shuai
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2016, Volume 26, Issue 18, pp. 4408 - 4413
A series of 4,6-disubstituted quinazoline derivatives as potential PI3K inhibitors were designed and synthesized. All compounds exhibited significant... 
Anti-proliferative | Synthesis | Quinazoline derivatives | PI3K inhibitor | Antitumor | RAPAMYCIN | TARGET | DESIGN | CHEMISTRY, MEDICINAL | VIVO | ANTICANCER AGENTS | CHEMISTRY, ORGANIC | CANCER | DISCOVERY | 3-KINASES | IN-VITRO | HIGHLY POTENT | MCF-7 Cells | HCT116 Cells | Humans | Enzyme Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinazolines - pharmacology | Drug Screening Assays, Antitumor
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17. Full Text Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity
by Li, Xitao and Zuo, Yingying and Tang, Guanghui and Wang, Yan and Zhou, Yiqing and Wang, Xueying and Guo, Tianlin and Xia, Mengying and Ding, Ning and Pan, Zhengying
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2014, Volume 57, Issue 12, pp. 5112 - 5128
Bruton's tyrosine kinase (Btk) is an attractive drug target for treating several B-cell lineage cancers. Ibrutinib is a first-in-class covalent irreversible... 
BCR | GROWTH-FACTOR RECEPTOR | POTENT | ACTIVATION | CHEMISTRY, MEDICINAL | B-CELL-RECEPTOR | BTK INHIBITOR | SELECTIVE INHIBITORS | MECHANISMS | ARTHRITIS | RATIONAL DESIGN | Neoplasm Transplantation | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Lymphoma, B-Cell | Pyrimidines - chemistry | Heterografts | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Acrylamides - pharmacology | Benzamides - chemistry | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Benzamides - chemical synthesis | Mice, Inbred ICR | Acrylamides - chemistry | Animals | Cell Line, Tumor | Acrylamides - chemical synthesis | Drug Screening Assays, Antitumor | Protein-Tyrosine Kinases - antagonists & inhibitors
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18. Full Text Synthesis and antitumor activity of novel 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives
by Liu, Gang and Liu, Fang and Huai, Ziyou and Xia, Guotai and Song, Liuping and Li, Sha and Xu, Yulan and Hong, Kangjun and Yao, Mingyue and Huang, Yinjiu
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2018, Volume 28, Issue 14, pp. 2561 - 2565
Inhibitory effect of 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline on ERK1/2 phosphorylation in SGC7901 cells induced by EGF. After treatment of... 
Synthesis | 4-Anilinoquinazoline | Epidermal growth factor receptor (EGFR) | Antitumor | DESIGN | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | QUINAZOLINE DERIVATIVES | COMBINATION | LAPATINIB | LUNG-CANCER | EGFR INHIBITORS | POTENT | BIOLOGICAL EVALUATION | RESISTANCE | RECEPTOR TYROSINE KINASE | Quinazolines - chemical synthesis | Protein Kinase Inhibitors - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | Epidermal Growth Factor - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Phosphorylation - drug effects | Quinazolines - pharmacology | Quinazolines - chemistry | Drug Screening Assays, Antitumor | Mitogen-Activated Protein Kinase 1 - metabolism | Anthracyclines | Analysis | Epidermal growth factor
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