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Cell Stem Cell, ISSN 1934-5909, 11/2009, Volume 5, Issue 5, pp. 491 - 503
Journal Article
Journal Article
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 08/2012, Volume 3, Issue 8, pp. 658 - 662
Activating mutations in leucine-rich repeat kinase 2 (LARK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive... 
blood-brain barrier | 2,4-diaminopyrimidine | LRRK2 | brain penetrant inhibitor | KINASE 2 LRRK2 | POTENT | CHEMISTRY, MEDICINAL | MODELS | NEURODEGENERATION | TOXICITY | SELECTIVITY | PARKINSONS-DISEASE
Journal Article
Cancer Research, ISSN 0008-5472, 12/2016, Volume 76, Issue 23, pp. 7001 - 7011
Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase pathways are drivers of malignant progression in glioblastoma multiforme,... 
HDAC4 | INACTIVATION | SURVIVAL | MITOSIS | HISTONE DEACETYLASE 4 | POTENT | GENOMICS | ONCOLOGY | PROTEIN PHOSPHATASE 2A | PANOBINOSTAT | MOUSE MODELS | Animals | Transfection | Protein Kinase Inhibitors - therapeutic use | Glioma - pathology | Humans | Protein Phosphatase 2 - metabolism | Mice | Glioma - drug therapy | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2015, Volume 28, Issue 1, pp. 70 - 81
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4597 - 4610
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2017, Volume 60, Issue 7, pp. 2819 - 2839
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this... 
TRIALS | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | DOCKING | PROTEIN-PROTEIN INTERACTION | FLUORINE | P53 PATHWAY | HIGHLY POTENT | RG7112 | Neoplasms - metabolism | Osteosarcoma - drug therapy | Bone and Bones - pathology | Leukemia - pathology | Humans | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Structure-Activity Relationship | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Bone and Bones - drug effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Bridged Bicyclo Compounds - chemistry | Bone and Bones - metabolism | Bridged Bicyclo Compounds - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Osteosarcoma - metabolism | Bridged Bicyclo Compounds - pharmacology | Pyrrolidines - pharmacokinetics | Leukemia - drug therapy | Rats | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidines - chemistry | Neoplasms - drug therapy | Animals | Halogenation | Cell Line, Tumor | Indoles - pharmacokinetics | Indoles - therapeutic use | Mice | Molecular Docking Simulation | Bridged Bicyclo Compounds - pharmacokinetics | Neoplasms - pathology | Indoles - chemistry | Osteosarcoma - pathology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 48, pp. 20435 - 20439
Journal Article