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European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, pp. 221 - 234
Alzheimer's disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since... 
Acetylcholinesterase inhibitors | Diphenylpyrimidine | MAO inhibitors | Alzheimer's disease | Dual inhibitors | Neurological disorders | Acetylchollnesterase inhibitors | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | CHOLINESTERASE-INHIBITORS | NEUROPROTECTION | MULTITARGET-DIRECTED LIGANDS | DONEPEZIL | BIOLOGICAL EVALUATION | POTENTIAL TREATMENT | MULTIPOTENT MAO | HYBRIDS | Alkynes - chemical synthesis | Cholinesterase Inhibitors - toxicity | Pyrimidines - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Pyrimidines - chemistry | Monoamine Oxidase - chemistry | Pyrimidines - toxicity | Drug Design | Alkynes - pharmacology | Molecular Structure | Monoamine Oxidase Inhibitors - pharmacology | Catalytic Domain | Alzheimer Disease - drug therapy | Alkynes - chemistry | Acetylcholinesterase - chemistry | Pyrimidines - pharmacology | Molecular Dynamics Simulation | Monoamine Oxidase Inhibitors - toxicity | Cholinesterase Inhibitors - pharmacology | Alkynes - toxicity | Cell Line, Tumor | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Kinetics | Oxidases | Molecular dynamics | Development and progression | Nervous system diseases | Enzyme inhibitors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2502 - 2514
Purpose: The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the... 
BREAST-CANCER | MULTIPLE-MYELOMA | APOPTOSIS | PHASE-II TRIAL | TANESPIMYCIN 17-AAG | TRASTUZUMAB | ONCOLOGY | BIM | ACQUIRED-RESISTANCE | MELANOMA-CELLS | POTENTIAL MECHANISM | Prospective Studies | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immunoenzyme Techniques | Forkhead Transcription Factors - metabolism | Colony-Forming Units Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phthalic Acids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins B-raf - metabolism | Membrane Proteins - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Forkhead Box Protein O3 | Azabicyclo Compounds - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects
Journal Article
Biomedical Chromatography, ISSN 0269-3879, 02/2013, Volume 27, Issue 2, pp. 148 - 155
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 124 - 169
The presence of -heterocycles as an essential structural motif in a variety of biologically active substances has stimulated the development of new strategies... 
Bioactive heterocycles | Enzymes | Biological potential | Synthetic methods | Inhibitors | Cross-coupling reactions | CHEMISTRY, MEDICINAL | ONE-POT SYNTHESIS | CRYSTAL-STRUCTURE | INHIBITORY-ACTIVITY | EFFICIENT SYNTHESIS | NATIONAL-CANCER-INSTITUTE | DOMINO SYNTHESIS | SUBSTITUTED QUINAZOLINES | BIOLOGICAL EVALUATION | OXIDATIVE SYNTHESIS | HETEROGENEOUS CATALYST | Phosphotransferases - metabolism | Quinazolines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Glucuronidase - metabolism | Phosphotransferases - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Anticonvulsants - pharmacology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Glucuronidase - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Quinazolines - chemistry | Angiogenesis Inhibitors - chemical synthesis | Quinazolinones - pharmacology | Anticonvulsants - chemical synthesis | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Anti-Bacterial Agents - chemical synthesis | Quinazolinones - chemical synthesis | Anticonvulsants - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Quinazolinones - chemistry | Quinazolines - pharmacology | Angiogenesis Inhibitors - chemistry
Journal Article
2000, Handbook of experimental pharmacology, ISBN 9783540661276, Volume 147., xxxi, 662
Book
FEBS Letters, ISSN 0014-5793, 01/2017, Volume 591, Issue 1, pp. 240 - 251
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7395 - 7418
Melanins are pigment molecules that determine the skin, eye, and hair color of the human subject to its amount, quality, and distribution. Melanocytes... 
B16 MELANOMA-CELLS | PROTEIN-KINASE-A | POTENTIAL TYROSINASE INHIBITORS | IN-VITRO | CHEMISTRY, MEDICINAL | MUSHROOM TYROSINASE | SPLIT-FACE TRIAL | MAPK SIGNALING PATHWAY | DOWN-REGULATION | 4-N-BUTYLRESORCINOL 0.1-PERCENT CREAM | P-COUMARIC ACID
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 368, Issue 1, pp. 88 - 96
Highlights • xCT is highly expressed in CRC. • SSZ promotes substantial accumulation of ROS in CRC. • SSZ and CDDP cause more than additive ROS accumulation in... 
Hematology, Oncology and Palliative Medicine | xCT | Sulfasalazine | Chemosensitization | Cisplatin | Colorectal cancer | ROS | XCT | DRUG | 1ST-LINE TREATMENT | CELLS | POTENTIAL USE | TRANSPORT | THERAPY | ONCOLOGY | GLUTATHIONE | GROWTH | RESISTANCE | LEUKEMIA | Reactive Oxygen Species - metabolism | Glutathione - metabolism | HCT116 Cells | Humans | Sulfasalazine - pharmacology | Antioxidants - pharmacology | Cisplatin - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | HT29 Cells | Amino Acid Transport System y+ - metabolism | Amino Acid Transport System y+ - antagonists & inhibitors | Cell Proliferation - drug effects | Histones - metabolism | Oxidative Stress - drug effects | Colorectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Drug Resistance, Neoplasm - drug effects | Reactive oxygen species | Cysteine | Toxicity | Epithelial cells | Colorectal carcinoma | DNA damage | Acetylcysteine | Cytotoxicity | Cancer therapies | Anticancer properties | Cystine | Antioxidants | Synthesis | Platinum | Inhibition | Colon | Deoxyribonucleic acid--DNA | Glutathione | Enzymes | Mortality | Detoxification | Inflammation | FDA approval | Tumor cell lines | Studies | Inflammatory bowel disease | Chemotherapy | Cell lines | N-Acetyl-L-cysteine | Intracellular | Synergistic effect | Transporter | Apoptosis | Cancer | Index Medicus
Journal Article