X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (476) 476
humans (376) 376
cystic fibrosis (306) 306
animals (246) 246
potentiator (242) 242
cftr potentiator (230) 230
pharmacology & pharmacy (220) 220
mutation (197) 197
respiratory system (180) 180
ivacaftor (165) 165
cystic fibrosis transmembrane conductance regulator - genetics (151) 151
potentiators (151) 151
cystic fibrosis - drug therapy (142) 142
cystic fibrosis - genetics (137) 137
in-vitro (115) 115
chemistry, medicinal (113) 113
male (111) 111
transmembrane conductance regulator (108) 108
cftr (91) 91
cystic-fibrosis (87) 87
female (85) 85
rats (82) 82
biochemistry & molecular biology (81) 81
neurosciences (81) 81
aminophenols - therapeutic use (78) 78
quinolones - therapeutic use (78) 78
cystic fibrosis transmembrane conductance regulator - metabolism (77) 77
analysis (70) 70
mice (70) 70
g551d mutation (68) 68
adult (60) 60
efficacy (59) 59
article (57) 57
proteins (56) 56
cystic fibrosis transmembrane conductance regulator (55) 55
disease (55) 55
genetic aspects (55) 55
microbiology (55) 55
glutamate (54) 54
identification (54) 54
vx-770 (54) 54
cystic fibrosis - physiopathology (52) 52
cystic fibrosis - metabolism (51) 51
chemistry, organic (50) 50
pulmonary/respiratory (50) 50
care and treatment (49) 49
immunology (48) 48
lumacaftor (48) 48
schizophrenia (48) 48
dose-response relationship, drug (47) 47
safety (46) 46
structure-activity relationship (46) 46
critical care medicine (45) 45
child (44) 44
pharmacology (44) 44
aminophenols - pharmacology (43) 43
quinolones - pharmacology (43) 43
adolescent (42) 42
cell biology (42) 42
macrophage infectivity potentiator (42) 42
treatment outcome (41) 41
activation (40) 40
pediatrics (39) 39
research (39) 39
biotechnology & applied microbiology (38) 38
congenital, hereditary, and neonatal diseases and abnormalities (38) 38
correctors (38) 38
expression (38) 38
positive allosteric modulator (38) 38
abridged index medicus (37) 37
allosteric regulation (37) 37
drug synergism (37) 37
gene (36) 36
young adult (36) 36
cell line (35) 35
drug therapy (34) 34
ampa receptor potentiator (33) 33
cells, cultured (33) 33
discovery (33) 33
clinical trials (32) 32
lung-disease (32) 32
medicine (32) 32
corrector (31) 31
cystic fibrosis - therapy (31) 31
f508del-cftr mutation (31) 31
protein (31) 31
resistance (31) 31
small-molecule correctors (31) 31
double-blind (30) 30
medicine, research & experimental (30) 30
molecular structure (30) 30
aminophenols - administration & dosage (29) 29
children (29) 29
health aspects (29) 29
mechanism (29) 29
microbial sensitivity tests (29) 29
pseudomonas-aeruginosa (29) 29
quinolones - administration & dosage (29) 29
antibiotics (28) 28
conductance (28) 28
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (876) 876
Japanese (19) 19
French (6) 6
Spanish (6) 6
Chinese (3) 3
German (2) 2
Polish (2) 2
Czech (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 9351 - 9355
A functional high throughput screen and subsequent multidimensional, iterative parallel synthesis effort identified the first muscarinic acetylcholine receptor... 
M-1 | CHEMISTRY, MEDICINAL | POTENTIATORS
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 10/2013, Volume 56, Issue 20, pp. 8196 - 8200
The M, mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh... 
CHEMISTRY, MEDICINAL | POTENTIATORS | BINDING
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2688 - 2701
Advanced leads of an imidazopyridine series of positive allosteric modulators of the metabotropic glutamate 2 (mGlu2) receptor are reported. The optimization... 
MGLU2 | ACTIVATION | CHEMISTRY, MEDICINAL | RAT | PHARMACOLOGY | PROGRESS | POTENTIATORS | EXPRESSION | AGONIST
Journal Article
JOURNAL OF CYSTIC FIBROSIS, ISSN 1569-1993, 01/2018, Volume 17, Issue 1, pp. 89 - 95
Background: Ivacafior has been shown to improve lung function and body weight in patients with CF and a gating mutation. Real-world evaluation is warranted to... 
G551D MUTATION | POTENTIATOR IVACAFTOR | EFFICACY | SAFETY | RESPIRATORY SYSTEM | CFTR modulators | Cystic fibrosis | Lumacaftor | CFTR POTENTIATOR
Journal Article
Recent Patents on Drug Delivery and Formulation, ISSN 1872-2113, 2009, Volume 3, Issue 1, pp. 26 - 39
According to the year 2003 survey of pediatricians by the American Association of Pediatrics, unpleasant taste was the biggest barrier for completing treatment... 
Taste potentiators | Taste suppressants | Sweeteners | Taste masking
Journal Article
by Long, Y and Tang, T and Wang, LY and He, B and Gao, K
JOURNAL OF NATURAL PRODUCTS, ISSN 0163-3864, 08/2019, Volume 82, Issue 8, pp. 2229 - 2237
Eleven new meroterpenoids, bipolahydroquinones A-C (1-3), cochlioquinones I-N (4-8 and 11), and isocochlioquinones F and G (9 and 10), together with six known... 
PHARMACOLOGY & PHARMACY | CHEMISTRY, MEDICINAL | STEMPHONES | POTENTIATORS | PLANT SCIENCES
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6495 - 6512
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit S. In this article, we describe a... 
LY379268 | LY354740 | ANTIPSYCHOTIC ACTIVITY | ACTIVATION | CHEMISTRY, MEDICINAL | PHARMACOLOGY | PROTEIN-COUPLED RECEPTORS | SCHIZOPHRENIA | PHASE-2 | POTENTIATORS | AGONIST
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 07/2014, Volume 52, pp. 192 - 200
Journal Article
CURRENT OPINION IN PHARMACOLOGY, ISSN 1471-4892, 06/2017, Volume 34, pp. 105 - 111
These are exciting times in the development of therapeutics for cystic fibrosis (CF). New correctors and potentiators of the cystic fibrosis transmembrane... 
TRANSMEMBRANE-CONDUCTANCE-REGULATOR | DIRECT BINDING | POTENTIATOR VX-770 IVACAFTOR | FUNCTIONAL EXPRESSION | PHE508DEL CFTR | ION-CHANNEL | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | CFTR POTENTIATOR | PLASMA-MEMBRANE | PREVENTS INHIBITION
Journal Article
EUROPEAN RESPIRATORY JOURNAL, ISSN 0903-1936, 07/2019, Volume 54, Issue 1
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 02/2020, Volume 30, Issue 3, p. 126812
This Letter details our efforts to discover structurally unique M PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of... 
CHEMISTRY, MEDICINAL | M-4 | Positive allosteric modulator (PAM) | Structure activity relationship (SAR) | CHEMISTRY, ORGANIC | RECEPTOR | OPTIMIZATION | POTENTIATORS | DERIVATIVES | Muscarinic acetylcholine receptor
Journal Article
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2017, Volume 195, Issue 12, pp. 1617 - 1628
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 07/2013, Volume 9, Issue 7, pp. 444 - U69
The most common cystic fibrosis mutation, Delta F508 in nucleotide binding domain 1 (NBD1), impairs cystic fibrosis transmembrane conductance regulator... 
TRANSMEMBRANE CONDUCTANCE REGULATOR | TRAFFICKING DEFECT | CHANNEL FUNCTION | CONFORMATIONAL MATURATION | PHARMACOLOGICAL CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | CYSTIC-FIBROSIS MUTATION | QUALITY-CONTROL | CFTR POTENTIATOR | SMALL-MOLECULE CORRECTORS
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 11/2019, Volume 29, Issue 21
This Letter details our efforts to replace the 2,4-dimethylquinoline carboxamide core of our previous M-4 PAM series, which suffered from high predicted... 
CHEMISTRY, MEDICINAL | M-4 | Positive allosteric modulator (PAM) | PRECLINICAL CANDIDATE | Structure activity relationship (SAR) | CHEMISTRY, ORGANIC | RECEPTOR | POTENTIATORS | Muscarinic acetylcholine receptor
Journal Article
Marine Drugs, ISSN 1660-3397, 01/2016, Volume 14, Issue 1, p. 19
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.