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Journal Article
Yeast, ISSN 0749-503X, 12/1996, Volume 12, Issue 16, pp. 1647 - 1675
Since the isolation of the first yeast protein phosphatase genes in 1989, much progress has been made in understanding this important group of proteins. Yeast... 
PP1 | Sit4 | PP2B | PP2A | calcineurin | phosphorylation | yeast | protein phosphatase | Phosphorylation | PP2 | Yeast | Calcineurin | Protein phosphatase
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 303 - 311
IRBIT is an IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor]-binding protein that competes with IP3 for binding to the IP3R. Phosphorylation of IRBIT is... 
Casein kinase 1 | R | Phosphorylation | Calcium | Inositol 1,4,5-trisphosphate receptor (IP | Protein phosphatase-1 (PP1) | Signalling | SITE | calcium | KINASE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | MASS-SPECTROMETRY | protein phosphatase-1 (PP1) | inositol 1,4,5-trisphosphate receptor (IP3R) | casein kinase 1 | IP3 RECEPTOR | SUBSTRATE RECOGNITION MOTIFS | SUPPRESSES | phosphorylation | BINDING | signalling | MODULATION | Protein Phosphatase 1 - physiology | Animals | Calcium Channels - metabolism | Membrane Glycoproteins - metabolism | Inositol 1,4,5-Trisphosphate Receptors | Protein Binding | Adenosylhomocysteinase - metabolism | Mice | Binding Sites | Receptors, Cytoplasmic and Nuclear - metabolism | mIRBIT, mouse IRBIT | MK-2, MAPK-activated protein kinase 2 | PP2, protein phosphatase-2 | PKD, protein kinase D | IRBIT, IP3R-binding protein released by IP3 | TBS, Tris-buffered saline | DTT, dithiothreitol | HRP, horseradish peroxidase | AKAP9, A-kinase anchoring protein 9 | CaMK, Ca2 | IP3, inositol 1,4,5-trisphosphate | GST, glutathione transferase | GFP, green fluorescent protein | calmodulin-dependent protein kinase | PKC, protein kinase C | PP1, protein phosphatase-1 | NIPP1, nuclear inhibitor of PP1 | AHCY, S-adenosylhomocysteine hydrolase | IP3R, IP3 receptor | AMPK, AMP-activated kinase | CK1, casein kinase 1 | EGFP, enhanced GFP | IPTG, isopropyl β-D-thiogalactoside | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2006, Volume 341, Issue 2, pp. 363 - 368
Exposure of MDA-MB-468 cells to ionizing radiation (IR) caused biphasic activation of ERK as indicated by its phosphorylation at Thr202/Tyr204. Specific... 
AG1478 | Ionizing radiation | SHP-2 | PP2 | Src | Transactivation | EGFR | ERK | CARCINOMA-CELLS | MECHANISM | src | PHOSPHORYLATION | PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | transactivation | BIOPHYSICS | PATHWAY | HYDROGEN-PEROXIDE | IONIZING-RADIATION | ionizing radiation | EGF RECEPTOR | MODULATION | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Temperature | Immunoprecipitation | Humans | Transcriptional Activation | Immunoblotting | Protein Tyrosine Phosphatases - metabolism | Guanosine Triphosphate - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Quinazolines | Time Factors | Infrared Rays | src-Family Kinases - metabolism | Tyrosine - chemistry | Radiation, Ionizing | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Epidermal Growth Factor - metabolism | Tyrphostins - pharmacology | Pyrimidines - pharmacology | Androstadienes - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | X-Rays | Cell Line, Tumor | Ligands | Enzyme Activation | Kinetics | Dose-Response Relationship, Radiation | Mitogen-Activated Protein Kinase 1 - metabolism | Tyrosine | Phenols | Phosphatidylinositol | Epidermal growth factor | Universities and colleges | Radiation | GROWTH FACTORS | IRRADIATION | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | LIGANDS | TYROSINE | BIOLOGICAL RADIATION EFFECTS | RECEPTORS | IONIZING RADIATIONS
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2006, Volume 397, Issue 2, pp. 337 - 344
PI3K (phosphoinositide 3-kinase) activity is involved in Ang (angiotensin) II-stimulated VSMC (vascular smooth muscle cell) growth and hypertrophy. In the... 
Angiotensin (Ang) | Vascular smooth muscle cell (VSMC) | Phosphoinositide 3-kinase (PI3K) | Platelet-derived growth factor receptor-β (PDGFR-β) | Tyrosine phosphorylation | Receptor stimulation | receptor stimulation | DOWNSTREAM TARGET | angiotensin (Ang) | ANG-II | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | IDENTIFICATION | phosphoinositide 3-kinase (PI3K) | TRANSACTIVATION | GENE-EXPRESSION | vascular smooth muscle cell (VSMC) | tyrosine phosphorylation | platelet-derived growth factor receptor-beta (PDGFR-beta) | SIGNALING CASCADES | TYPE-1 | Protein Structure, Tertiary | Cell Line | Phosphorylation | Angiotensin II - metabolism | Muscle, Smooth, Vascular - metabolism | Receptor, Platelet-Derived Growth Factor beta - physiology | Rats | Phosphatidylinositol 3-Kinases - metabolism | Receptor, Platelet-Derived Growth Factor beta - chemistry | Rats, Sprague-Dawley | Receptor, Angiotensin, Type 1 - chemistry | Animals | Protein Binding | Angiotensin II - physiology | VSMC, vascular smooth muscle cell | GST, glutathione S-transferase | PI3K, phosphoinositide 3-kinase | CAS, Crk-associated substrate | Ang, angiotensin | MS, tandem MS | platelet-derived growth factor receptor-β (PDGFR-β) | PDGFR-β, platelet-derived growth factor receptor-β | PAI-1, plasminogen activator inhibitor-1 | PTP2, protein tyrosine phosphatase 2 | Shc, Src homology and collagen homology | AT1, Ang II subtype 1 | SH2, Src homology 2 | IGF-1, insulin-like growth factor-1 | PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2004, Volume 381, Issue 3, pp. 919 - 928
We have previously shown that CD32A (or FcgammaRIIA), one of the main opsonin receptors, was rapidly insolubilized and degraded in intact neutrophils after its... 
CD32A signalling | Src kinase | Fc receptor | Neutrophil | Detergent-resistant membrane domain | Tyrosine phosphorylation | detergent-resistant membrane domain | SYK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANCHORED PROTEINS | neutrophil | MEDIATED PHAGOCYTOSIS | SIGNAL-TRANSDUCTION | BLOOD POLYMORPHONUCLEAR LEUKOCYTES | MONOCYTIC THP-1 CELLS | T-CELL-ACTIVATION | LIPID RAFTS | tyrosine phosphorylation | ASSOCIATION | Receptors, Immunologic - chemistry | Humans | Receptors, IgG - chemistry | Protein Transport - physiology | Protein Transport - drug effects | Cytoplasmic Granules - chemistry | beta-Cyclodextrins - pharmacology | Receptors, IgG - metabolism | Antigens, CD - metabolism | Cell Membrane - chemistry | Protein-Tyrosine Kinases - chemistry | Antigens, CD - chemistry | Cell Membrane - metabolism | Phosphorylation - drug effects | Neutrophils - metabolism | Syk Kinase | Tyrosine - chemistry | Cytoplasm - chemistry | Neutrophils - chemistry | Cross-Linking Reagents - chemistry | Detergents - metabolism | Enzyme Precursors - chemistry | Solubility | Intracellular Signaling Peptides and Proteins | Pyrimidines - pharmacology | Tyrosine - metabolism | Models, Biological | src-Family Kinases - chemistry | Receptors, Immunologic - metabolism | GAM, goat F(ab′)2 anti-mouse IgG | ITAM, immunoreceptor tyrosine-based activation motif | iPr2P-F, di-isopropyl fluorophosphate | RLB, relaxation buffer | NP40, Nonidet P40 | DRM, detergent-resistant membrane | M-β-CD, methyl-β-cyclodextrin | OGD, N-octyl-β-D-glucoside | PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
Journal Article