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Gut, ISSN 0017-5749, 07/2016, Volume 65, Issue 7, pp. 1202 - 1214
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2012, Volume 40, Issue 7, pp. 1366 - 1379
...), pregnane X receptor (PXR), peroxisome proliferator-activated receptor alpha (PPAR alpha), and nuclear factor erythroid 2-related factor 2 (Nrf2... 
TRANSCRIPTION FACTORS | PRIMARY HUMAN HEPATOCYTES | ANTIOXIDANT RESPONSE ELEMENT | MESSENGER-RNA EXPRESSION | CONSTITUTIVE ANDROSTANE RECEPTOR | BILIARY-EXCRETION | PROLIFERATOR-ACTIVATED RECEPTOR | MOUSE-LIVER | PHARMACOLOGY & PHARMACY | MICROSOMAL-ENZYME INDUCERS | PREGNANE-X-RECEPTOR | Inactivation, Metabolic | Receptors, Steroid - metabolism | Cytochrome P-450 Enzyme System - metabolism | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Organic Anion Transporters - genetics | Glutathione Transferase - genetics | Receptors, Aryl Hydrocarbon - metabolism | Female | NF-E2-Related Factor 2 - genetics | Sulfotransferases - metabolism | Aldehyde Dehydrogenase - metabolism | Sulfotransferases - genetics | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Receptors, Aryl Hydrocarbon - genetics | Glutathione Transferase - metabolism | Aldehyde Dehydrogenase - genetics | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Animals | Glucuronosyltransferase - metabolism | Receptors, Steroid - genetics | NF-E2-Related Factor 2 - metabolism | Cytochrome P-450 Enzyme System - genetics | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | PPAR alpha - metabolism | Multidrug Resistance-Associated Proteins | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2012, Volume 287, Issue 42, pp. 35161 - 35169
Journal Article
Cancer Research, ISSN 0008-5472, 11/2011, Volume 71, Issue 21, pp. 6888 - 6898
.... PPAR gamma coactivator 1 alpha (PGC1 alpha) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis... 
BREAST-CANCER | ESTROGEN-RELATED RECEPTOR | OXIDATIVE-PHOSPHORYLATION | FATTY-ACID SYNTHESIS | ONCOLOGY | ERR-ALPHA | NUCLEAR RECEPTORS | PGC-1 | PPAR-GAMMA | CELL-GROWTH | ENERGY-METABOLISM | Neoplasm Transplantation | Colonic Neoplasms - genetics | Colonic Neoplasms - prevention & control | Humans | Liver Neoplasms, Experimental - chemically induced | Colonic Neoplasms - chemically induced | Cell Line, Tumor - transplantation | Liver Neoplasms, Experimental - prevention & control | Acetyl-CoA Carboxylase - genetics | Trans-Activators - physiology | Fatty Acid Synthases - biosynthesis | Organic Anion Transporters - genetics | Lipogenesis - genetics | Cell Transformation, Neoplastic - genetics | Carcinoma, Hepatocellular - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Trans-Activators - genetics | Liver Neoplasms - pathology | Cell Line, Tumor - metabolism | Fatty Acid Synthases - genetics | Fatty Acids - metabolism | Gene Expression Regulation, Neoplastic - genetics | Liver Neoplasms - genetics | Oxidative Phosphorylation | Mitochondria - metabolism | Mice, SCID | Mice, Knockout | Citric Acid Cycle - genetics | Animals | Trans-Activators - deficiency | Colonic Neoplasms - pathology | Carcinoma, Hepatocellular - pathology | Acetyl-CoA Carboxylase - biosynthesis | Mice | Transcription Factors | Organic Anion Transporters - biosynthesis | Index Medicus | oxidative metabolism | Warburg Effect | lipogenesis | Cancer metabolism | transcriptional regulation
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0173676
Autophagy is a catabolic mechanism to degrade cellular components to maintain cellular energy levels during starvation, a condition where PPAR alpha may be activated... 
INSULIN SIGNALING TRANSDUCTION | GLUCOSE-HOMEOSTASIS | FIBROBLAST-GROWTH-FACTOR-21 | DEACETYLATION | METABOLISM | PATHWAY | STEATOSIS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | RECEPTORS | FOXO1 | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes
Journal Article
Journal Article
Toxicology, ISSN 0300-483X, 2017, Volume 387, pp. 95 - 107
Abstract Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane... 
Emergency | Peroxisome proliferator-activated receptor α | STAT5B | Peroxisome proliferator-activated receptor γ | Perfluoroalkyl acid | Transcript profiling | Liver | Estrogen receptor alpha | ToxCast | Constitutive activated receptor | SPRAGUE-DAWLEY RATS | Peroxisome proliferator-activated receptor gamma | HEPATOCELLULAR HYPERTROPHY | NUCLEAR RECEPTORS | Peroxisome proliferator-activated receptor alpha | CELL-PROLIFERATION | PROLIFERATOR-ACTIVATED-RECEPTOR | AMMONIUM PERFLUOROOCTANOATE | PERFLUOROOCTANE SULFONATE PFOS | DEVELOPMENTAL TOXICITY | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PERFLUORINATED COMPOUNDS | Hepatomegaly - pathology | Fluorocarbons - toxicity | Transcription, Genetic - drug effects | Liver - pathology | Estrogens - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Databases, Genetic | Male | Mice, 129 Strain | PPAR gamma - metabolism | STAT5 Transcription Factor - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Estrogen Receptor alpha - metabolism | Chemical and Drug Induced Liver Injury - pathology | PPAR gamma - genetics | Liver - metabolism | Computational Biology | Gene Expression Regulation | Gene Expression Profiling - methods | PPAR alpha - genetics | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Chemical and Drug Induced Liver Injury - genetics | Hepatomegaly - genetics | Pyrimidines - pharmacology | Sulfonic Acids - toxicity | Mice, Knockout | PPAR alpha - deficiency | Animals | Estrogen Receptor alpha - genetics | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Hepatomegaly - chemically induced | PPAR gamma - agonists | PPAR alpha - agonists | Hepatomegaly - metabolism | Anticholesteremic Agents - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | peroxisome proliferator | liver | constitutive activated receptor | activated receptor γ | estrogen receptor alpha | perfluoroalkyl acid | transcript profiling | peroxisome proliferator-activated receptor α
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 43, pp. 29751 - 29765
Background: Although both are involved in metabolic homeostasis, the interconnection between ER stress and FGF21 remains incompletely understood. Results:... 
BETA-KLOTHO | PPAR-ALPHA | Fibroblast Growth Factor (FGF) | FATTY LIVER-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | Unfolded Protein Response (UPR) | Liver Metabolism | ENERGY-EXPENDITURE | ER Stress | Hepatocyte | METABOLIC REGULATOR | MESSENGER-RNA | TRANSCRIPTION FACTOR | FGF21 | Organ Specificity - drug effects | Non-alcoholic Fatty Liver Disease - pathology | Transcription, Genetic - drug effects | Transcriptional Activation - genetics | Fatty Liver - pathology | Humans | Transcriptional Activation - drug effects | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Fibroblast Growth Factors - genetics | Molecular Sequence Data | Hepatocytes - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Hepatocytes - metabolism | Endoplasmic Reticulum Stress - genetics | Promoter Regions, Genetic - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Fibroblast Growth Factors - metabolism | Organ Specificity - genetics | Base Sequence | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Fatty Liver - genetics | Unfolded Protein Response - drug effects | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Mice, Inbred C57BL | Non-alcoholic Fatty Liver Disease - metabolism | Signal Transduction - genetics | Recombinant Proteins - pharmacology | Enzyme Activation - drug effects | Regulatory Factor X Transcription Factors | Hep G2 Cells | Transcription Factors - metabolism | Animals | Diet | Signal Transduction - drug effects | Mice, Obese | Molecular Biophysics
Journal Article
Biochemical journal, ISSN 1470-8728, 2005, Volume 386, Issue 3, pp. 575 - 581
PPARα (peroxisome-proliferator-activated receptor α) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that regulate... 
E-box | Peroxisome-proliferator-activated receptor α (PPARα) | Circadian rhythm | Transcription | CLOCK | Liver | transcription | CDNA MICROARRAY | liver | peroxisome-proliferator-activated receptor alpha (PPAR alpha) | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERIPHERAL-TISSUES | DIFFERENTIAL REGULATION | MOLECULAR ANALYSIS | MUTANT MICE | TARGET GENES | MESSENGER-RNA | SUPRACHIASMATIC NUCLEUS | circadian rhythm | GENE-EXPRESSION | NIH 3T3 Cells | Transcriptional Activation - genetics | Humans | Diabetes Mellitus, Type 1 - metabolism | Molecular Sequence Data | RNA, Messenger - metabolism | Chromatin Immunoprecipitation | Base Sequence | Trans-Activators - genetics | Fibroblasts | Response Elements - genetics | Dimerization | Basic Helix-Loop-Helix Transcription Factors | ARNTL Transcription Factors | Introns - genetics | Liver - metabolism | RNA, Messenger - genetics | Circadian Rhythm - genetics | PPAR alpha - genetics | Adrenalectomy | Transcription Factors - metabolism | Animals | CLOCK Proteins | Trans-Activators - deficiency | Trans-Activators - metabolism | Mice | Dex, dexamethasone | STZ, streptozotocin | RXR, retinoid X receptor | DTT, dithiothreitol | ChIP, chromatin immunoprecipitation | DMEM, Dulbecco's modified Eagle's medium | PPARα, peroxisome-proliferator-activated receptor α | peroxisome-proliferator-activated receptor α (PPARα) | CRY, cryptochrome | PAS, Per-Arnt-Sim | DBP, albumin D-site-binding protein | bHLH, basic helix–loop–helix | ET-1, endothelin-1 | EMSA, electrophoretic mobility-shift assay | ADX, adrenalectomized | MEF, mouse embryonic fibroblast | FBS, foetal bovine serum | SCN, suprachiasmatic nucleus | BMAL1, brain and muscle Arnt-like protein 1 | PER, period
Journal Article