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Cell, ISSN 0092-8674, 2008, Volume 134, Issue 3, pp. 405 - 415
The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise... 
SIGNALING | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | ENDURANCE EXERCISE | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | GENE-EXPRESSION | GLUCOSE-TRANSPORT | RECEPTOR-DELTA | HUMAN SKELETAL-MUSCLE | DIRECT PHOSPHORYLATION | CELL BIOLOGY | oxidative metabolism | running endurance | AMPK | exercise | genetic re-programming | skeletal muscle | PPARδ
Journal Article
LIFE SCIENCES, ISSN 0024-3205, 12/2013, Volume 93, Issue 25-26, pp. 963 - 967
Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPAR... 
PPAR beta/delta | MEDICINE, RESEARCH & EXPERIMENTAL | Preclinical studies | ACTIVATED-RECEPTOR-DELTA | CHOLESTEROL | Induction and transrepression | PROSTACYCLIN | GW501516 | CELL-PROLIFERATION | COLON | IDENTIFICATION | Function | CARCINOGENESIS | PHARMACOLOGY & PHARMACY | Dose | LIGAND ACTIVATION | PEROXISOME
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 10/2013, Volume 32, Issue 44, pp. 5241 - 5252
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2019, Volume 842, pp. 248 - 254
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 12/2018, Volume 59, Issue 50, pp. 4384 - 4386
Peroxisome proliferator-activated receptor delta (PPARδ) is considered as a promising biological target for the development of new drugs to treat metabolic... 
GW501516 | d-Penicillamine | 4-Mercapto-2-methylphenol | PPAR agonists | TBAHS catalyst | D-Penicillamine | BETA/DELTA | DESIGN | PPAR-DELTA | GROWTH | CHEMISTRY, ORGANIC
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, pp. 352 - 365
The free fatty acid receptor 1 (FFA1 or GPR40) and peroxisome proliferator-activated receptor δ (PPARδ) have attracted a lot of attention due to their role in... 
FFA1 | Hybrid | Diabetes | PPAR | Dual agonist | TARGET | DESIGN | CHEMISTRY, MEDICINAL | PHENOXYACETIC ACID-DERIVATIVES | INSULIN-SECRETION | DRUG DISCOVERY | RECEPTOR 1 AGONISTS | DELTA PPAR-DELTA | BIOLOGICAL EVALUATION | ANIMAL-MODELS | PANCREATIC BETA-CELLS
Journal Article
Journal Article
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2015, Volume 21, Issue 45, pp. 12787 - 12799
AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty... 
stea | fatty | liver | Nonalcoholic | disease;Nonalcoholic | Nucleotide-binding and oligomerization domain-like receptor | Inflammasome | Nonalcoholic fatty liver disease | Nonalcoholic steatohepatitis | Peroxisome proliferator-activated receptors delta | ACID | MEDITERRANEAN DIET | NLRP3 INFLAMMASOME | INSULIN SENSITIVITY | OBESITY | GLUCOSE-METABOLISM | OVERWEIGHT PATIENTS | STEATOHEPATITIS | MICE | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Inflammasomes - metabolism | Humans | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Lipopolysaccharides | Inflammasomes - antagonists & inhibitors | Liver - drug effects | Time Factors | Diet, High-Fat | Inflammation Mediators - metabolism | Hepatocytes - drug effects | Cytoprotection | Disease Models, Animal | Non-alcoholic Fatty Liver Disease - genetics | Anti-Inflammatory Agents - pharmacology | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Palmitic Acid - toxicity | Non-alcoholic Fatty Liver Disease - metabolism | Inflammasomes - genetics | Hep G2 Cells | Blood Glucose - drug effects | Animals | Signal Transduction - drug effects | PPAR delta - agonists | Non-alcoholic Fatty Liver Disease - prevention & control | Thiazoles - pharmacology | Oxidative Stress - drug effects | PPAR delta - metabolism | Blood Glucose - metabolism | Basic Study
Journal Article
Atherosclerosis, ISSN 0021-9150, 2011, Volume 220, Issue 2, pp. 470 - 476
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2001, Volume 98, Issue 9, pp. 5306 - 5311
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism. The hypolipidemic... 
Obesity | Biological Sciences | Lipoproteins | Receptors | HDL lipoproteins | Primates | Agonists | Lipids | Triglycerides | Macrophages | Cholesterols | DEPENDENT DIABETES-MELLITUS | APOLIPOPROTEIN C-III | TANGIER-DISEASE | DENSITY-LIPOPROTEIN CHOLESTEROL | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | BINDING CASSETTE TRANSPORTER-1 | PPAR-GAMMA AGONISTS | CORONARY HEART-DISEASE | HYPOLIPIDEMIC DRUGS | INSULIN SENSITIVITY | Intestines - drug effects | Obesity - drug therapy | Cholesterol - blood | Humans | Substrate Specificity | Male | Metabolic Diseases - drug therapy | Hyperinsulinism - drug therapy | Intestines - metabolism | Macaca mulatta | Thiazoles - therapeutic use | Insulin - blood | RNA, Messenger - metabolism | Obesity - blood | ATP-Binding Cassette Transporters - genetics | Drug Design | ATP-Binding Cassette Transporters - metabolism | Biological Transport - drug effects | ATP Binding Cassette Transporter 1 | Hyperinsulinism - blood | Fibroblasts - metabolism | Hyperinsulinism - metabolism | Cell Line | Fasting | Blood Glucose - analysis | RNA, Messenger - genetics | Insulin Resistance | Metabolic Diseases - blood | Receptors, Cytoplasmic and Nuclear - agonists | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Obesity - metabolism | Transcription Factors - metabolism | Macrophages - metabolism | Animals | Metabolic Diseases - metabolism | Fibroblasts - drug effects | Triglycerides - blood | Cholesterol, HDL - blood | Macrophages - drug effects | Thiazoles - pharmacology | Transcription Factors - agonists | Intestines - cytology | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article