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Physical chemistry chemical physics : PCCP, ISSN 1463-9076, 04/2016, Volume 18, Issue 13, pp. 9272 - 9280
... the NRs. The high H12 flexibility in the apo PPAR gamma form and the lack of appropriate antagonist ligands complicate the structural and dynamics description by most of the experimental techniques... 
Physical Sciences | Chemistry | Physics, Atomic, Molecular & Chemical | Chemistry, Physical | Physics | Science & Technology | Protein Conformation | Molecular Dynamics Simulation | PPAR gamma - chemistry | Index Medicus | Exchange | Molecular conformation | Receptors | Molecular dynamics | Chains | Ligands | Activation | Deviation
Journal Article
Journal of molecular and cellular cardiology, ISSN 0022-2828, 07/2014, Volume 72, pp. 85 - 94
Abstract Tumor necrosis factor-α (TNF-α) is an established pro-atherosclerotic factor, but the mechanism is not completely understood. We explored whether... 
Cardiovascular | NF-κB | TNF-α | LDL | PPAR-γ | Atherosclerosis | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Nitriles - pharmacology | Atherosclerosis - genetics | Humans | NF-kappa B - metabolism | Filipin - pharmacology | PPAR gamma - metabolism | Sulfones - pharmacology | Caveolin 2 - antagonists & inhibitors | Thiocarbamates - pharmacology | Human Umbilical Vein Endothelial Cells - cytology | Proline - pharmacology | Benzamides - pharmacology | Lipoproteins, LDL - metabolism | PPAR gamma - genetics | Caveolin 1 - antagonists & inhibitors | Receptors, LDL - genetics | Atherosclerosis - pathology | NF-kappa B - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - drug effects | Proline - analogs & derivatives | Signal Transduction | Atherosclerosis - chemically induced | Receptors, LDL - antagonists & inhibitors | Gene Expression Regulation | Caveolin 1 - genetics | Receptors, LDL - metabolism | Mice, Knockout | Caveolin 1 - metabolism | Caveolin 2 - metabolism | Cinchona Alkaloids - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Lipoproteins, LDL - antagonists & inhibitors | NF-kappa B - genetics | Anilides - pharmacology | Mice | Pyridines - pharmacology | Transcytosis - drug effects | Caveolin 2 - genetics | Atherosclerosis - prevention & control | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76541 - e76541
Peroxisome proliferator activator receptors (PPAR) ligands such as 15-Delta 12,13-prostaglandin L(2) [PJ] and all trans retinoic acid (ATRA) have been shown to... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cyclin D1 - metabolism | Rats, Wistar | TOR Serine-Threonine Kinases - metabolism | Actins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Hepatic Stellate Cells - metabolism | Male | G1 Phase - drug effects | PPAR gamma - metabolism | Receptors, Retinoic Acid - genetics | Actins - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | Collagen Type I - genetics | TOR Serine-Threonine Kinases - genetics | Prostaglandin D2 - analogs & derivatives | G1 Phase - genetics | Retinoid X Receptors - antagonists & inhibitors | Retinoid X Receptors - genetics | Retinoid X Receptors - metabolism | Hepatic Stellate Cells - pathology | Hepatic Stellate Cells - drug effects | PPAR gamma - genetics | Tretinoin - pharmacology | Collagen Type I - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | rho GTP-Binding Proteins - genetics | Collagen Type I - antagonists & inhibitors | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Receptors, Retinoic Acid - metabolism | rho GTP-Binding Proteins - agonists | Drug Synergism | Gene Expression Regulation - drug effects | Actins - antagonists & inhibitors | Animals | PPAR gamma - antagonists & inhibitors | Cyclin D1 - genetics | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Cell Proliferation - drug effects | Prostaglandin D2 - pharmacology | Primary Cell Culture | Cyclin-Dependent Kinase Inhibitor p27 - genetics | TOR protein | Cell proliferation | Pediatrics | Flow cytometry | GTP-binding protein | Phosphorylation | Liver | Retinoic acid receptors | Kinases | Cyclin D1 | Proteins | Vitamin A | Receptors | Cell activation | Cell growth | Rodents | Gastroenterology | Cell cycle | Down-regulation | Extracellular matrix | Inhibition | Growth factors | G1 phase | Stellate cells | Liver diseases | Gene expression | Retinoid X receptors | Medicine | Hospitals | Acids | Collagen | Fibrosis | Ligands | Combined treatment | Peroxisome proliferator-activated receptors | Laboratory animals | Retinoic acid | Index Medicus | Activation
Journal Article
Neurotoxicity research, ISSN 1029-8428, 1/2017, Volume 31, Issue 1, pp. 77 - 89
Journal Article
PloS one, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e37097 - e37097
.... Here, we report that three selective PPAR beta/delta antagonists, GSK0660, compound 3 h, and GSK3787... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Benzamides - pharmacokinetics | Skin - metabolism | Humans | Thiophenes - administration & dosage | PPAR gamma - metabolism | Benzamides - administration & dosage | Psoriasis - genetics | Psoriasis - pathology | Psoriasis - metabolism | Ointments | Skin - pathology | Disease Models, Animal | PPAR gamma - genetics | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Psoriasis - drug therapy | PPAR-beta - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Skin Absorption | Recombinant Proteins - genetics | Sulfones - pharmacokinetics | PPAR-beta - genetics | Thiophenes - pharmacokinetics | Animals | PPAR gamma - antagonists & inhibitors | PPAR-beta - antagonists & inhibitors | Mice | Administration, Topical | Skin - drug effects | Sulfones - administration & dosage | Animal models | Pathogenesis | Multiple myeloma | Antagonists | Arthritis | Activation | Metastasis | Stomach cancer | Vehicles | Signal transduction | Atherosclerosis | Skin diseases | Life sciences | Inhibition | Growth factors | Medical research | Psoriasis | Dermatology | Research & development--R&D | Rheumatology | Transgenic mice | Mass spectroscopy | Epidermis | Data processing | Inflammation | Liquid chromatography | Dentistry | Metabolism | High-performance liquid chromatography | Chromatography | Medicine | Signaling | Chemistry | Nursing | Acids | Ligands | Skin | Peroxisome proliferator-activated receptors | Topical application | Mass spectrometry | High performance liquid chromatography | Index Medicus | Research & development | R&D
Journal Article
Lipids in health and disease, ISSN 1476-511X, 09/2017, Volume 16, Issue 1, pp. 181 - 181
Background: Increased consumption of omega-3 (omega-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A... 
Obesity | Adipocyte differentiation | Stearidonic acid | 3T3-L1 | Omega-3 fatty acids | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Fatty Acid Synthase, Type I - genetics | Lipoprotein Lipase - antagonists & inhibitors | Fatty Acid-Binding Proteins - antagonists & inhibitors | Glucose Transporter Type 4 - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - antagonists & inhibitors | Adipocytes - cytology | Adipocytes - drug effects | Fatty Acid-Binding Proteins - metabolism | PPAR gamma - metabolism | Fatty Acids, Omega-3 - pharmacology | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | CCAAT-Enhancer-Binding Proteins - genetics | Lipoprotein Lipase - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | PPAR gamma - genetics | CCAAT-Enhancer-Binding Proteins - metabolism | Glucose Transporter Type 4 - antagonists & inhibitors | Cell Survival - drug effects | Glucose Transporter Type 4 - genetics | Lipoprotein Lipase - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Stearoyl-CoA Desaturase - antagonists & inhibitors | 3T3-L1 Cells | Fatty Acid Synthase, Type I - metabolism | Fatty Acid-Binding Proteins - genetics | Stearoyl-CoA Desaturase - genetics | CCAAT-Enhancer-Binding Protein-beta - metabolism | Fatty Acid Synthase, Type I - antagonists & inhibitors | Gene Expression Regulation - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Animals | PPAR gamma - antagonists & inhibitors | Sterol Regulatory Element Binding Protein 1 - genetics | Cell Differentiation - drug effects | Adipocytes - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Lipid Metabolism - drug effects | Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors | Stearoyl-CoA Desaturase - metabolism | Mice | CCAAT-Enhancer-Binding Protein-beta - antagonists & inhibitors | Usage | Care and treatment | Analysis | Development and progression | Liquid chromatography | Glucose transporter | Vegetable oils | Soybeans | Transcription factors | Fish oils | Toxicity | Gene regulation | Preadipocytes | Mass spectroscopy | Stearoyl-CoA desaturase | Lipoprotein lipase | Adipocytes | Lipase | Desaturase | Gene expression | Fatty acids | Fatty-acid synthase | Polymerase chain reaction | Rodents | Down-regulation | Sterol regulatory element-binding protein | Index Medicus
Journal Article