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1. Full Text Structure optimization of a new class of PPARγ antagonists
by Hernandez-Olmos, Victor and Knape, Tilo and Heering, Jan and von Knethen, Andreas and Kilu, Whitney and Kaiser, Astrid and Wurglics, Mario and Helmstädter, Moritz and Merk, Daniel and Schubert-Zsilavecz, Manfred and Parnham, Michael J and Steinhilber, Dieter and Proschak, Ewgenij
Bioorganic & medicinal chemistry, ISSN 0968-0896, 11/2019, Volume 27, Issue 21, pp. 115082 - 115082
MTTB | PPARγ antagonist | Competitive PPARγ antagonist | SAR | SPPARγMs | PPARγ | PPARγ agonist | Index Medicus
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2. Full Text Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice
by Matsusue, Kimihiko and Aibara, Daisuke and Hayafuchi, Risa and Matsuo, Kohei and Takiguchi, Soichi and Gonzalez, Frank J and Yamano, Shigeru
FEBS letters, ISSN 0014-5793, 06/2014, Volume 588, Issue 14, pp. 2277 - 2281
Liver X receptor α | Peroxisome proliferator-activated receptor γ | Fatty liver | normal genetic background | Pparγ ΔH | hepatocyte-specific PPARγ knockout | LXRα | OB/OB | Pparγ WT | obese genetic background | wild-type PPARγ | liver X receptor α | peroxisome proliferator-activated receptor γ | PPARγ | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Liver - pathology | Fatty Liver - metabolism | Liver - metabolism | Orphan Nuclear Receptors - agonists | Hydrocarbons, Fluorinated - pharmacology | Blood Glucose | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Mice, Knockout | PPAR gamma - physiology | Animals | Liver X Receptors | Orphan Nuclear Receptors - physiology | Mice, Obese | Mice | Lipogenesis | Anticholesteremic Agents - pharmacology | Index Medicus | γ | Peroxisome proliferator-activated receptor
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3. Full Text Exploring the mechanism of PPARγ phosphorylation mediated by CDK5
by Ribeiro Filho, H.V and Guerra, J.V and Cagliari, R and Batista, F.A.H and Le Maire, A and Oliveira, P.S.L and Figueira, A.C.M
Journal of structural biology, ISSN 1047-8477, 09/2019, Volume 207, Issue 3, pp. 317 - 326
PPARγ ligands | Non-contiguous phosphorylation site | PPARγ phosphorylation | Cyclin-dependent kinase 5 | PPARγ:CDK5/p25 docking model | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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4. Full Text Possible involvement of 15‐deoxy‐Δ12,14‐prostaglandin J2 in the development of leptin resistance
by Hosoi, Toru and Matsuzaki, Syu and Miyahara, Tsuyoshi and Shimizu, Kaori and Hasegawa, Yuki and Ozawa, Koichiro
Journal of neurochemistry, ISSN 0022-3042, 05/2015, Volume 133, Issue 3, pp. 343 - 351
15d‐PGJ2 | PPAR‐γ | leptin | STAT3 | PPAR-γ | 15d-PGJ
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5. Full Text Stereoisomers ginsenosides-20(S)-Rg 3 and -20(R)-Rg 3 differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma
by Kwok, Hoi-Hin and Guo, Guan-Lun and Lau, Justin Kai-Chi and Cheng, Yuen-Kit and Wang, Jiang-Rong and Jiang, Zhi-Hong and Keung, Man-Hong and Mak, Nai-Ki and Yue, Patrick Ying-Kit and Wong, Ricky Ngok-Shun
Biochemical pharmacology, ISSN 0006-2952, 04/2012, Volume 83, Issue 7, pp. 893 - 902
Angiogenesis | Stereoisomer | Ginsenoside | PPARγ
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6. Full Text Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR‐γ2 transcription factor and TGF‐β/BMP signaling pathways
by Moerman, Elena J and Teng, Kui and Lipschitz, David A and Lecka‐Czernik, Beata
Aging cell, ISSN 1474-9718, 12/2004, Volume 3, Issue 6, pp. 379 - 389
marrow stem cells | PPAR‐γ | aging | osteoblast | TGF‐β/BMP | adipocyte | Aging | Osteoblast | Adipocyte | TGF-β/BMP | Marrow stem cells | PPAR-γ | BMP | TGF-β
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7. Full Text Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor γ indole partial agonists
by Eeda, Venkateswararao and Wu, Dan and Lim, Hui-Ying and Wang, Weidong
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 11/2019, Volume 29, Issue 22, pp. 126664 - 126664
Obesity | Partial agonist | Insulin resistance | Diabetes | PPARγ | TZD | PPARγ agonist | Index Medicus
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8. Full Text Incorporation of a coumarin unit by nucleophilic addition reaction into a PPARγ ligand
by Yoshikawa, Chisato and Ishida, Hiroaki and Itoh, Toshimasa
Tetrahedron letters, ISSN 0040-4039, 05/2020, Volume 61, Issue 19, p. 151842
Lactonization | PPARγ ligand | Coumarin | Fluorescent ligand
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9. Full Text PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease
by Corona, Juan Carlos and Duchen, Michael R
Free radical biology & medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. 153 - 163
Neuroprotection | PPARγ agonists | Mitochondrial function | Neurodegenerative disorders | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Neuroprotective Agents - therapeutic use | Humans | Alzheimer Disease - drug therapy | Mitochondria - metabolism | Parkinson Disease - drug therapy | Mitochondria - drug effects | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Huntington Disease - metabolism | Amyotrophic Lateral Sclerosis - drug therapy | PPAR gamma - pharmacology | PPAR gamma - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - pharmacology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Mitochondria - physiology | Disease Models, Animal | Index Medicus | GSK-3β, glycogen synthase kinase-3β | BDNF, brain derived neurotrophic factor | SRC, steroid receptor coactivator | Aβ, protein amyloid-β | UCP-2, uncoupling protein 2 | Bcl-2, B-cell lymphoma2 | Review | Nrf2, nuclear factor erythroid-derived 2-like 2 | ALS, amyotrophic lateral sclerosis | HD, huntington's disease | NRF1, nuclear respiratory factor 1 | AF-1, transcriptional activation domain | LPS, lipopolysacchacaride | PPARγ, peroxisome proliferation-activated receptor gamma | UCP-1, uncoupling protein 1 | mtDNA, mitochondrial DNA | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PD, parkinson's disease | TDP-43, TAR DNA-binding protein 43 | Cdk5, cyclin-dependent kinase 5 | COX-2, cyclooxygenase-2 | PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1α | SOD1, superoxide dismutase 1 | HO-1, haem oxygenase-1 | BAT, brown adipose tissue | AD, alzheimer's disease | Bax, Bcl-2-associated X protein | TZDs, thiazolidinediones | ΔΨm, mitochondrial membrane potential | 15D-PGJ2, 15-deoxy-Δ12,14-Prostaglandin J2 | MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | CBP, CREB-binding protein | CNS, central nervous system | WAT, white adipose tissue | 6-OHDA, 6-hydroxydopamine | NF-κB, nuclear factor-κB | iNOS, inducible nitric oxide synthase | TFAM, mitochondrial transcription factor A | MPP+, 1-methyl-4-phenylpyridinium ion | NRF2, nuclear respiratory factor 2
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10. Full Text Potential of natural products in the inhibition of adipogenesis through regulation of PPARγ expression and/or its transcriptional activity
by Feng, Shi and Reuss, Laura and Wang, Yu
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2016, Volume 21, Issue 10, p. 1278
PPARγ transcriptional activity | Obesity | PPARγ expression | Natural products | PPARγ | Adipogenesis | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Obesity - diet therapy | Adipogenesis - drug effects | CCAAT-Enhancer-Binding Protein-beta - genetics | Humans | Transcriptional Activation - drug effects | Adipocytes - drug effects | Obesity - genetics | Sirtuin 1 - genetics | PPAR gamma - biosynthesis | Obesity - pathology | Gene Expression Regulation - drug effects | AMP-Activated Protein Kinases - genetics | Biological Products - therapeutic use | PPAR gamma - genetics | Index Medicus | natural products | adipogenesis | obesity
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11. Full Text Pioglitazone improves virological response to peginterferon α‐2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance
by Khattab, Mahmoud and Emad, Mohammed and Abdelaleem, Asharf and Eslam, Mohammed and Atef, Rabab and Shaker, Yehia and Hamdy, Lamia
Liver international, ISSN 1478-3223, 03/2010, Volume 30, Issue 3, pp. 447 - 454
pioglitazone | PPAR‐γ agonist | peg‐interferon | chronic hepatitis C | Chronic hepatitis C | PPAR-γ agonist | Peg-interferon | Pioglitazone
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