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The international journal of neuropsychopharmacology, ISSN 1461-1457, 06/2019, Volume 22, Issue 6, pp. 372 - 382
Although depression is the leading cause of disability worldwide, its pathophysiology is poorly understood. Our previous study showed that hippocampal... 
neurogenesis | depression | hippocampus | BDNF | PPARδ
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 2019
Neuronal expression of beta-secretase 1 (BACE1) has been implicated in the progression of Alzheimer's disease. However, the mechanisms that regulate BACE1... 
BACE1 | SOCS1 | STAT1 | Alzheimer's disease | amyloid beta | PPARδ
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2018, Volume 26, Issue 15, pp. 4382 - 4389
In this study, we designed and synthesized several novel “Y”-shaped biaryl PPARδ agonists. Structure-activity relationship (SAR) studies demonstrated that... 
Structure-activity relationship (SAR) | Nuclear receptors | ADMET | PPARδ | PK
Journal Article
International Journal of Obesity, ISSN 0307-0565, 2014, Volume 38, Issue 3, pp. 456 - 465
Journal Article
Cancer research, ISSN 0008-5472, 7/2013, Volume 73, Issue 14, pp. 4349 - 4361
The peroxisome proliferator-activated receptor-δ (PPARδ) regulates a multitude of physiological processes associated with glucose and lipid metabolism,... 
mTor | transgenic | Plac1 | tumorigenesis | PPARδ
Journal Article
Cell, ISSN 0092-8674, 2008, Volume 134, Issue 3, pp. 405 - 415
The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise... 
SIGNALING | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | ENDURANCE EXERCISE | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-FUNCTION | GENE-EXPRESSION | GLUCOSE-TRANSPORT | RECEPTOR-DELTA | HUMAN SKELETAL-MUSCLE | DIRECT PHOSPHORYLATION | CELL BIOLOGY | oxidative metabolism | running endurance | AMPK | exercise | genetic re-programming | skeletal muscle | PPARδ
Journal Article
Journal of Animal Science, ISSN 0021-8812, 06/2018, Volume 96, Issue 7, pp. 2763 - 2776
Abstract All-trans retinoic acid (ATRA) has been associated with various physiological phenomenon in mammalian adipose tissue and skeletal muscle. We... 
Muscle Biology | all-trans retinoic acid | bovine satellite cells | cell culture | PPARδ
Journal Article
Fish and Shellfish Immunology, ISSN 1050-4648, 11/2019, Volume 94, pp. 38 - 49
Peroxisome proliferator-activated receptor δ (PPAR-δ), also called PPAR-β or PPAR-β/δ, is a member of the peroxisome proliferator-activated receptor (PPAR)... 
Interferon-stimulated gene | PPAR-δ | Singapore grouper iridovirus | Peroxisome proliferator-activated receptor δ | Inflammatory factor | Grouper | Viral replication | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 08/2019, Volume 857, pp. 172425 - 172425
As a nuclear receptor, ligand binding and activated PPARδ (peroxisome-proliferator-activated receptor δ) plays an important role in regulation of inflammation,... 
Glut1 | GW501516 | AMPK | Metformin | SLC1A5 | Transcriptional activity | PPARδ | SURVIVAL | RISK | DIABETIC-PATIENTS | COLON-CANCER | TRANSPORT | METABOLISM | ADIPONECTIN | PATHWAY | GLUCOSE | PHARMACOLOGY & PHARMACY | PPARd
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 515, Issue 2, pp. 352 - 358
Obesity-associated insulin resistance is a forerunner of type 2 diabetes. Macrophages reside within adipose tissue (ATMs) have been reported to regulate... 
PPAR-δ | Insulin resistance | miRNAs | Exosomes | ATMs | PPAR-delta | BIOPHYSICS | EXTRACELLULAR VESICLES | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | DELIVERY | Adipose tissues | Type 2 diabetes | Obesity | MicroRNA | Macrophages
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 08/2019, Volume 234, Issue 8, pp. 13252 - 13262
Although cardiac hypertrophy is widely recognized as a risk factor that leads to cardiac dysfunction and, ultimately, heart failure, the complex mechanisms... 
cardiac hypertrophy; microRNA; nuclear receptor PPARδ; isoproterenol hydrochloride; transcriptional regulation | Heart | Therapeutic applications | MiRNA | Lipids | Atrial natriuretic peptide | Isoproterenol | Metabolism | Risk analysis | Risk factors | Ribonucleic acids | Lipid metabolism | Heart diseases | Hypertrophy
Journal Article
Yaoxue Xuebao, ISSN 0513-4870, 11/2014, Volume 49, Issue 11, pp. 1536 - 1542
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 3, pp. 533 - 536
Comparison of gene regulation profiles, efficacy in thermal injury model and 14-day rat toxicity studies. Compound regulates significantly fewer genes than the... 
Ki-67 | PPARδ modulator | GW501516 | Thermal injury model | Gene expression | POPULATION | CHEMISTRY, MEDICINAL | RAT | PPAR delta modulator | CHEMISTRY, ORGANIC | EXPRESSION | CANCER | IMMUNOHISTOCHEMISTRY | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1307 - 1314
Oxidative stress plays an important role in the development of diabetic retinopathy. Here, we examined whether α-lipoic acid (α-LA), a natural antioxidant,... 
AMPK | TXNIP | OGT | PPARδ | SIRT3 | APOPTOSIS | SIGNALING PATHWAYS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PPARS | BIOPHYSICS | METABOLISM | GLUCOSE | INFLAMMATION | RETINOPATHY | Antioxidants | Diabetic retinopathy | Medical colleges | Cell death | Biochemistry | Protein kinases | Sugars | Monosaccharides | Index Medicus
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 2012, Volume 30, Issue 6, pp. 662 - 683
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2008, Volume 7, Issue 3, pp. 521 - 529
Activation of the Wnt/β-catenin signaling pathway occurs in several types of cancers and thus it is an attractive target for anticancer drug development. To... 
β-catenin | Wnt | PPARγ and PPARδ | Tcf | ONCOGENIC BETA-CATENIN | ANDROGEN RECEPTOR | COLON-CANCER CELLS | TRANSCRIPTIONAL ACTIVATION | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | POLYP FORMATION | LIGAND | PROLIFERATOR-ACTIVATED-RECEPTOR | BINDING | COACTIVATORS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 22, pp. 7815 - 7820
It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria in skeletal muscle. In keeping with this hypothesis, high-fat... 
Mitochondria | Messenger RNA | Nonesterified fatty acids | Muscles | Rats | Insulin resistance | Type 2 diabetes mellitus | Muscle mitochondria | Skeletal muscle | High fat diet | PGC-1α | Mitochondrial biogenesis | Mitochondrial dysfunction | PPARδ | ACTIVATED PROTEIN-KINASE | PPAR delta | PGC-1 alpha | MULTIDISCIPLINARY SCIENCES | mitochondrial dysfunction | GLUCOSE-TRANSPORT | mitochondrial biogenesis | RECEPTOR-GAMMA COACTIVATOR-1-ALPHA | HUMAN SKELETAL-MUSCLE | EXERCISE | ACID CONCENTRATION | BIOGENESIS | PPAR-DELTA | GENE-EXPRESSION | DYSFUNCTION | skeletal muscle | Body Weight | Oxidation-Reduction | Rats, Wistar | Diet - adverse effects | Mitochondria, Muscle - metabolism | Insulin Resistance | Muscle, Skeletal - ultrastructure | Male | Muscle, Skeletal - metabolism | Abdominal Fat - drug effects | Fatty Acids, Nonesterified - metabolism | Animals | Muscle, Skeletal - drug effects | PPAR delta - agonists | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Dietary Fats - administration & dosage | Trans-Activators - genetics | Fatty Acids, Nonesterified - blood | Trans-Activators - metabolism | Mitochondria, Muscle - drug effects | Transcription Factors | Evaluation | Fat metabolism | Properties | Risk factors | Proteins | Musculoskeletal system | Drug resistance | Insulin | Fatty acids | Rodents | Index Medicus | Biological Sciences
Journal Article