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Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 07/2011, Volume 31, Issue 7, pp. 1573 - U198
Objective-Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a ligand-activated transcription factor that controls lipid metabolism and... 
GAMMA | PPAR-ALPHA | FATTY LIVER-DISEASE | FENOFIBRATE | MOUSE | PPAR alpha | murine model | DEFICIENT MICE | UMCG Approved | fatty liver disease | inflammation | Atherosclerosis | CARDIOVASCULAR-DISEASE | STEATOHEPATITIS | AGONIST | PPARα | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Inflammation - pathology | Liver - pathology | Fatty Liver - pathology | Atherosclerosis - genetics | Humans | Aorta - metabolism | Fenofibrate - pharmacology | Inflammation - metabolism | Liver - drug effects | Inflammation - drug therapy | Lipids - blood | Non-alcoholic Fatty Liver Disease | Female | Lipid Metabolism - genetics | Disease Models, Animal | Fatty Liver - genetics | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Fatty Liver - metabolism | Anti-Inflammatory Agents - pharmacology | Apolipoprotein E2 - genetics | Aorta - drug effects | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | PPAR alpha - genetics | Hypolipidemic Agents - pharmacology | Apolipoprotein E2 - metabolism | Atherosclerosis - metabolism | Fatty Liver - drug therapy | Gene Knock-In Techniques | Mice, Knockout | Aorta - pathology | Homozygote | Animals | Analysis of Variance | Lipid Metabolism - drug effects | Inflammation - genetics | Heterozygote | PPAR alpha - agonists | Mice | PPAR alpha - metabolism | Anti-Inflammatory Agents | Liver | Lipids | Life Sciences | Aorta | Hypolipidemic Agents | Biochemistry, Molecular Biology | Lipid Metabolism | Inflammation | Apolipoprotein E2 | Fatty Liver | Fenofibrate | pathology | genetics | pharmacology | PPARalpha | drug therapy | drug effects | blood | agonists | metabolism
Journal Article
Investigative ophthalmology & visual science, ISSN 1552-5783, 2017, Volume 58, Issue 12, pp. 5030 - 5042
PURPOSE. Clinical studies have shown that peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist fenofibrate has therapeutic effects on diabetic... 
Angiogenesis | Diabetic retinopathy | Agonist | Inflammation | PPARα | Apoptosis | PPAR-ALPHA | LIPID-METABOLISM | OXYGEN-INDUCED RETINOPATHY | angiogenesis | NUCLEAR RECEPTORS | apoptosis | PPAR alpha | agonist | MODEL | diabetic retinopathy | BLOOD-RETINAL BARRIER | inflammation | OPHTHALMOLOGY | MICROVASCULAR CELLS | NEOVASCULARIZATION | ENDOTHELIAL GROWTH-FACTOR | Diabetic Retinopathy - drug therapy | Diabetes Mellitus, Experimental - drug therapy | Apoptosis - drug effects | Streptozocin | Transcriptional Activation | Diabetes Mellitus, Experimental - genetics | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | Male | Diabetic Retinopathy - pathology | Retinal Vessels - pathology | Rats, Inbred BN | Hydrocarbons, Chlorinated - therapeutic use | Angiogenesis Inhibitors - therapeutic use | Retinal Neovascularization - genetics | Disease Models, Animal | Electroretinography | In Situ Nick-End Labeling | Cell Line | Promoter Regions, Genetic | NF-kappa B - antagonists & inhibitors | Oxygen - toxicity | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Gene Expression Regulation - physiology | Rats | PPAR alpha - genetics | Blotting, Western | Diabetic Retinopathy - genetics | Animals | Diabetes Mellitus, Experimental - pathology | Endothelium, Vascular - pathology | Leukostasis | PPAR alpha - agonists | Mice | Quinolines - therapeutic use | PPAR alpha - metabolism | Retinal Neovascularization - drug therapy | Retinal Neovascularization - pathology | Cell Movement | Retina
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0153427
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e25565
Apart from its role during labor and lactation, oxytocin is involved in several other functions. Interestingly, oxytocin-and oxytocin receptor-deficient mice... 
BODY-WEIGHT | PPAR-ALPHA | TARGETED DISRUPTION | ADIPOCYTES | PLASMA | BIOLOGY | FAT | RECEPTOR GENE-EXPRESSION | DEFICIENT MICE | OLEOYLETHANOLAMIDE | MAMMARY-GLAND | Anti-Obesity Agents - blood | Oxytocin - pharmacology | Obesity - drug therapy | Diet - adverse effects | Body Weight - drug effects | Male | Dose-Response Relationship, Drug | Oleic Acids - metabolism | Adipose Tissue - metabolism | Oleic Acids - biosynthesis | Obesity - etiology | Endocannabinoids | Anti-Obesity Agents - metabolism | Anti-Obesity Agents - administration & dosage | Oxytocin - blood | Insulin Resistance | Rats | Obesity - physiopathology | PPAR alpha - genetics | Oxytocin - biosynthesis | Gene Knockout Techniques | Obesity - metabolism | Oxytocin - administration & dosage | PPAR alpha - deficiency | Animals | Mice | PPAR alpha - metabolism | Adipose Tissue - drug effects | Anti-Obesity Agents - pharmacology | Type 2 diabetes | Obesity | Enzymes | Monounsaturated fatty acids | Diet | Body weight | Physiological aspects | Insulin resistance | Adipose tissue | Lactation | Homeostasis | Body weight loss | Phospholipids | Adipocytes | Desaturase | High fat diet | Animal lactation | Infusion | Oxidation resistance | Oleic acid | Rodents | Coenzyme A | Physiology | Oxidation | Lipid metabolism | Drug dosages | Phosphatidylethanolamine | Oxytocin | Internal medicine | Diabetes mellitus | Weight loss | Triglycerides | Metabolism | Gene expression | Insulin | Body weight gain | Fatty acids | Lipolysis | Medicine | Glucose tolerance | Nutrition research | Intolerance | Weight control | Food intake | Peroxisome proliferator-activated receptors | Diabetes | Binding sites | Endocrinology
Journal Article
Obesity, ISSN 1930-739X, 2009, Volume 18, Issue 4, pp. 780 - 787
Obesity‐induced inflammation contributes to the development of obesity‐related metabolic disorders such as insulin resistance, type 2 diabetes, fatty liver... 
CRUCIAL ROLE | PPAR-ALPHA | METABOLIC SYNDROME | ACTIVATION | NUTRITION & DIETETICS | ADIPONECTIN | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | RECEPTOR | TNF-ALPHA | ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Dietary Fats - metabolism | Obesity - drug therapy | Capsaicin - pharmacology | Capsaicin - therapeutic use | Male | Insulin - blood | RNA, Messenger - metabolism | Adipose Tissue - metabolism | TRPV Cation Channels - metabolism | Flow Cytometry | Leptin - blood | Glucose Intolerance - etiology | Adiponectin - genetics | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - therapeutic use | Adiponectin - metabolism | Disease Models, Animal | Hypoglycemic Agents - therapeutic use | Gene Expression | Fatty Liver - metabolism | Anti-Inflammatory Agents - pharmacology | Obesity - complications | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | PPAR alpha - genetics | Reverse Transcriptase Polymerase Chain Reaction | Fatty Liver - drug therapy | TRPV Cation Channels - genetics | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Triglycerides - metabolism | Animals | Lipid Metabolism - drug effects | Inflammation - genetics | Mice, Obese | Mice | PPAR alpha - metabolism | Blood Glucose - metabolism | Dietary Supplements | PPAR alpha - chemistry | Fatty Liver - etiology
Journal Article