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Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 23, pp. 5918 - 5924
Purpose: In this era of precision-based medicine, for optimal patient care, results reported from commercial next-generation sequencing (NGS) assays should... 
RISK | GENOMICS | VARIANTS | ONCOLOGY | PPM1D | BLOOD
Journal Article
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 31623 - 31638
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2014, Volume 371, Issue 26, pp. 2477 - 2487
Journal Article
ISSN 1934-5909, 2018
Clonal hematopoiesis (CH), in which stem cell clones dominate blood production, becomes increasingly common with age and can presage malignancy development.... 
clonal hematopoiesis | CHIP | topoisomerase inhibitors | DNA damage response | etoposide | doxorubicin | t-MDS | PPM1D | cisplatin | t-AML
Journal Article
Human Mutation, ISSN 1059-7794, 12/2018, Volume 39, Issue 12, pp. 2040 - 2046
The Li-Fraumeni cancer predisposition syndrome (LFS1) presents with a variety of tumor types and the TP53 gene is covered by most diagnostic cancer gene... 
clonal hematopoiesis | PPM1D | chemotherapy | TP53 | Li-Fraumeni syndrome | CANCERS | GENETICS & HEREDITY | FRAMEWORK | BLOOD
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 08/2018, Volume 215, Issue 8, pp. 2137 - 2155
Ewing sarcoma is a pediatric cancer driven by EWS-ETS transcription factor fusion oncoproteins in an otherwise stable genomic background. The majority of... 
BREAST-CANCER | TARGET | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | OVEREXPRESSION | P53 GENE | MDM2 ANTAGONIST | GENE AMPLIFICATION | USP7 INHIBITION | MUTATIONS | IMMUNOLOGY | PPM1D
Journal Article
by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article
Cell Cycle, ISSN 1538-4101, 01/2017, Volume 16, Issue 2, pp. 213 - 223
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 10/2012, Volume 1271, Issue 1, pp. 58 - 67
Ovarian cancer is the most lethal gynecological malignancy. Cisplatin and its derivatives are first‐line chemotherapeutics, and their resistance is a major... 
functional food compounds | PPM1D | ovarian cancer chemoresistance | p53 | PI3K/Akt | Functional food compounds | Ovarian cancer chemoresistance | P53 | X-LINKED INHIBITOR | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | CISPLATIN RESISTANCE | ONCOGENIC PHOSPHATASE PPM1D | PROTEIN-KINASE B | NUCLEOTIDE EXCISION-REPAIR | AKT PHOSPHORYLATION | TUMOR-SUPPRESSOR | WIP1 PHOSPHATASE | NF-KAPPA-B | Apoptosis - drug effects | Humans | Phosphoprotein Phosphatases - metabolism | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Anticarcinogenic Agents - metabolism | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Antineoplastic Agents - metabolism | Antineoplastic Agents - adverse effects | Female | Anticarcinogenic Agents - adverse effects | Antineoplastic Agents - pharmacology | Antineoplastic Agents, Phytogenic - metabolism | Ovarian Neoplasms - metabolism | Antineoplastic Agents, Phytogenic - therapeutic use | Proto-Oncogene Proteins c-akt - metabolism | Anticarcinogenic Agents - pharmacology | Ovarian Neoplasms - drug therapy | Anticarcinogenic Agents - therapeutic use | Antineoplastic Agents, Phytogenic - adverse effects | Cell Survival - drug effects | Ovarian Neoplasms - prevention & control | Protein Phosphatase 2C | Tumor Suppressor Protein p53 - metabolism | Food, Fortified | Functional Food | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Protein Kinase Inhibitors - pharmacology | DNA Damage | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Protein Kinase Inhibitors - metabolism | Ovarian cancer | Apoptosis | Side effects | Pathways | Derivatives | Survival | Suppressors | Tumors | Cancer | PI3K | Akt | Original
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2018, Volume 23, Issue 5, pp. 700 - 713.e6
Clonal hematopoiesis (CH), in which stem cell clones dominate blood production, becomes increasingly common with age and can presage malignancy development.... 
clonal hematopoiesis | CHIP | topoisomerase inhibitors | DNA damage response | etoposide | t-MDS | doxorubicin | PPM1D | cisplatin | t-AML | EVOLUTION | PHOSPHATASE | DYNAMICS | WIP1 | LEUKEMIA | CANCER | BREAST | STEM | BLOOD | P53 | CELL & TISSUE ENGINEERING | CELL BIOLOGY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2010, Volume 70, Issue 10, pp. 4112 - 4122
The integrity of DNA is constantly challenged throughout the life of a cell by both endogenous and exogenous stresses. A well-organized rapid damage response... 
GENOMIC INSTABILITY | UV-IRRADIATION | PROTEIN PHOSPHATASE | SIGNALING PATHWAYS | GAMMA-H2AX FOCI | ONCOLOGY | DOUBLE-STRAND BREAKS | TUMOR-SUPPRESSOR | HISTONE H2AX | IONIZING-RADIATION | PPM1D
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 9/2017, Volume 134, Issue 2, pp. 465 - 467
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11060-017-2523-8 
Medicine & Public Health | Neurology | Oncology | ONCOLOGY | PPM1D | CLINICAL NEUROLOGY | Pediatrics | Gliomas
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 14, pp. 1598 - 1605
Journal Article